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Fiber intake and risk of nonfatal acute myocardial infarction.
Eur J Clin Nutr. 2003 Mar; 57(3):464-70.EJ

Abstract

OBJECTIVE

To investigate the association between fiber intake and risk of acute myocardial infarction (AMI), also according to type and source of fiber, in a Mediterranean country.

DESIGN

Hospital-based case-control study.

SETTING

Northern Italy.

SUBJECTS

A total of 507 cases of first nonfatal AMI and 478 controls in hospital for acute conditions.

INTERVENTIONS

Subjects were interviewed with a questionnaire that included a validated food frequency section. Odds ratios (OR) were obtained using multiple logistic regression, and adjusted for several recognized risk factors for AMI. Fiber was measured as non-starch polysaccharides.

RESULTS

Compared with the lowest one, the OR in the highest tertile was 0.72 for total fiber, 0.64 for soluble fiber, 0.77 for total insoluble fiber, 0.71 for cellulose, 0.81 for insoluble non-cellulosic polysaccharides, 0.82 for vegetable fiber, 0.64 for fruit fiber and 1.11 for cereal fiber, and the estimates were statistically significant for soluble and fruit fiber. When further adjusted for beta-carotene, vitamin C and vitamin E intake, the fruit fiber still showed the strongest inverse relation, although the association was no longer significant. The protective effect of fiber was more marked in, or restricted to, subjects with other AMI risk factors, such as smokers, diabetics and hypertensives.

CONCLUSIONS

Though an inverse association between fiber intake and AMI risk appears established, the causality of this association is still open to debate. In this population, cereal fiber derives chiefly from refined grains, and this may explain the lack of protection by this type of fiber.

Authors+Show Affiliations

Istituto di Richerche Farmacologiche Mario Negri, 20157 Milano, Italy. evanegri@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12627184

Citation

Negri, E, et al. "Fiber Intake and Risk of Nonfatal Acute Myocardial Infarction." European Journal of Clinical Nutrition, vol. 57, no. 3, 2003, pp. 464-70.
Negri E, La Vecchia C, Pelucchi C, et al. Fiber intake and risk of nonfatal acute myocardial infarction. Eur J Clin Nutr. 2003;57(3):464-70.
Negri, E., La Vecchia, C., Pelucchi, C., Bertuzzi, M., & Tavani, A. (2003). Fiber intake and risk of nonfatal acute myocardial infarction. European Journal of Clinical Nutrition, 57(3), 464-70.
Negri E, et al. Fiber Intake and Risk of Nonfatal Acute Myocardial Infarction. Eur J Clin Nutr. 2003;57(3):464-70. PubMed PMID: 12627184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fiber intake and risk of nonfatal acute myocardial infarction. AU - Negri,E, AU - La Vecchia,C, AU - Pelucchi,C, AU - Bertuzzi,M, AU - Tavani,A, PY - 2001/11/14/received PY - 2002/06/18/revised PY - 2002/06/18/accepted PY - 2003/3/11/pubmed PY - 2003/7/11/medline PY - 2003/3/11/entrez SP - 464 EP - 70 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 3 N2 - OBJECTIVE: To investigate the association between fiber intake and risk of acute myocardial infarction (AMI), also according to type and source of fiber, in a Mediterranean country. DESIGN: Hospital-based case-control study. SETTING: Northern Italy. SUBJECTS: A total of 507 cases of first nonfatal AMI and 478 controls in hospital for acute conditions. INTERVENTIONS: Subjects were interviewed with a questionnaire that included a validated food frequency section. Odds ratios (OR) were obtained using multiple logistic regression, and adjusted for several recognized risk factors for AMI. Fiber was measured as non-starch polysaccharides. RESULTS: Compared with the lowest one, the OR in the highest tertile was 0.72 for total fiber, 0.64 for soluble fiber, 0.77 for total insoluble fiber, 0.71 for cellulose, 0.81 for insoluble non-cellulosic polysaccharides, 0.82 for vegetable fiber, 0.64 for fruit fiber and 1.11 for cereal fiber, and the estimates were statistically significant for soluble and fruit fiber. When further adjusted for beta-carotene, vitamin C and vitamin E intake, the fruit fiber still showed the strongest inverse relation, although the association was no longer significant. The protective effect of fiber was more marked in, or restricted to, subjects with other AMI risk factors, such as smokers, diabetics and hypertensives. CONCLUSIONS: Though an inverse association between fiber intake and AMI risk appears established, the causality of this association is still open to debate. In this population, cereal fiber derives chiefly from refined grains, and this may explain the lack of protection by this type of fiber. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12627184/Fiber_intake_and_risk_of_nonfatal_acute_myocardial_infarction_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601559 DB - PRIME DP - Unbound Medicine ER -