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Hajj-associated outbreak strain of Neisseria meningitidis serogroup W135: estimates of the attack rate in a defined population and the risk of invasive disease developing in carriers.
Clin Infect Dis. 2003 Mar 15; 36(6):679-83.CI

Abstract

An outbreak of disease due to Neisseria meningitidis serogroup W135 (W135) occurred in 2000 and 2001 among pilgrims returning from the annual Islamic pilgrimage to Saudi Arabia (the Hajj) and in their contacts. For the Hajj in 2000, the attack rate of W135 disease was 25 cases per 100,000 pilgrims. After the introduction of quadrivalent meningococcal vaccine for the Hajj in 2001, no pilgrim developed W135 disease. The estimated attack rates for household contacts of returning pilgrims were 18 cases and 28 cases per 100,000 contacts for the years 2000 and 2001, respectively. On the basis of rates of transmission of W135 carriage and national epidemiological data, the risk that an unvaccinated household contact who had acquired W135 carriage would develop invasive meningococcal disease was estimated to be 1 case per 70 acquisitions. Public health policies to protect household contacts of Hajj pilgrims need to be implemented.

Authors+Show Affiliations

Wilder-Smith A
Travellers' Health and Vaccination Centre, Dept. of Infectious Diseases, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433. epvws@pacific.net.sg
Goh KT
No affiliation info available
Barkham T
No affiliation info available
Paton NI
No affiliation info available

MeSH

AdolescentAdultAgedCarrier StateChildChild, PreschoolDisease OutbreaksFemaleHumansInfantIslamMaleMeningitis, MeningococcalMiddle AgedNeisseria meningitidisRisk FactorsSerotypingSingapore

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12627350

Citation

Wilder-Smith, Annelies, et al. "Hajj-associated Outbreak Strain of Neisseria Meningitidis Serogroup W135: Estimates of the Attack Rate in a Defined Population and the Risk of Invasive Disease Developing in Carriers." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 36, no. 6, 2003, pp. 679-83.
Wilder-Smith A, Goh KT, Barkham T, et al. Hajj-associated outbreak strain of Neisseria meningitidis serogroup W135: estimates of the attack rate in a defined population and the risk of invasive disease developing in carriers. Clin Infect Dis. 2003;36(6):679-83.
Wilder-Smith, A., Goh, K. T., Barkham, T., & Paton, N. I. (2003). Hajj-associated outbreak strain of Neisseria meningitidis serogroup W135: estimates of the attack rate in a defined population and the risk of invasive disease developing in carriers. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 36(6), 679-83.
Wilder-Smith A, et al. Hajj-associated Outbreak Strain of Neisseria Meningitidis Serogroup W135: Estimates of the Attack Rate in a Defined Population and the Risk of Invasive Disease Developing in Carriers. Clin Infect Dis. 2003 Mar 15;36(6):679-83. PubMed PMID: 12627350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hajj-associated outbreak strain of Neisseria meningitidis serogroup W135: estimates of the attack rate in a defined population and the risk of invasive disease developing in carriers. AU - Wilder-Smith,Annelies, AU - Goh,Kee Tai, AU - Barkham,Timothy, AU - Paton,Nicholas I, Y1 - 2003/03/03/ PY - 2002/06/24/received PY - 2002/10/08/accepted PY - 2003/3/11/pubmed PY - 2003/3/21/medline PY - 2003/3/11/entrez SP - 679 EP - 83 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 36 IS - 6 N2 - An outbreak of disease due to Neisseria meningitidis serogroup W135 (W135) occurred in 2000 and 2001 among pilgrims returning from the annual Islamic pilgrimage to Saudi Arabia (the Hajj) and in their contacts. For the Hajj in 2000, the attack rate of W135 disease was 25 cases per 100,000 pilgrims. After the introduction of quadrivalent meningococcal vaccine for the Hajj in 2001, no pilgrim developed W135 disease. The estimated attack rates for household contacts of returning pilgrims were 18 cases and 28 cases per 100,000 contacts for the years 2000 and 2001, respectively. On the basis of rates of transmission of W135 carriage and national epidemiological data, the risk that an unvaccinated household contact who had acquired W135 carriage would develop invasive meningococcal disease was estimated to be 1 case per 70 acquisitions. Public health policies to protect household contacts of Hajj pilgrims need to be implemented. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/12627350/Hajj_associated_outbreak_strain_of_Neisseria_meningitidis_serogroup_W135:_estimates_of_the_attack_rate_in_a_defined_population_and_the_risk_of_invasive_disease_developing_in_carriers_ DB - PRIME DP - Unbound Medicine ER -