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Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark.
Fitoterapia. 2003 Feb; 74(1-2):159-63.F

Abstract

The extracts as well as piperolactum C, goniopedaline, 6beta-hydroxystigmasta-4,22-dien-3-one and a mixture of cis- and trans-4-hydroxymelleins obtained from Uvaria hamiltonii stem bark exhibited mild to moderate in vitro antibacterial activity. The results obtained were compared with a standard antibiotic, kanamycin. In a brine shrimp lethality bioassay the pet-ether, dichloromethane, methanol extracts and a major alkaloid, piperolactum C were found to exhibit mild to moderate cytotoxicity.

Authors+Show Affiliations

Asha KN
Faculty of Pharmacy, Department of Pharmaceutical Science, University of Dhaka, Dhaka 1000, Bangladesh.
Chowdhury R
No affiliation info available
Hasan CM
No affiliation info available
Rashid MA
No affiliation info available

MeSH

AnimalsAnti-Infective AgentsArtemiaDose-Response Relationship, DrugGram-Negative BacteriaGram-Positive BacteriaKanamycinLethal Dose 50Microbial Sensitivity TestsPhytotherapyPlant BarkPlant ExtractsUvaria

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12628415

Citation

Asha, K N., et al. "Antibacterial Activity and Cytotoxicity of Extractives From Uvaria Hamiltonii Stem Bark." Fitoterapia, vol. 74, no. 1-2, 2003, pp. 159-63.
Asha KN, Chowdhury R, Hasan CM, et al. Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark. Fitoterapia. 2003;74(1-2):159-63.
Asha, K. N., Chowdhury, R., Hasan, C. M., & Rashid, M. A. (2003). Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark. Fitoterapia, 74(1-2), 159-63.
Asha KN, et al. Antibacterial Activity and Cytotoxicity of Extractives From Uvaria Hamiltonii Stem Bark. Fitoterapia. 2003;74(1-2):159-63. PubMed PMID: 12628415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity and cytotoxicity of extractives from Uvaria hamiltonii stem bark. AU - Asha,K N, AU - Chowdhury,R, AU - Hasan,C M, AU - Rashid,M A, PY - 2003/3/12/pubmed PY - 2004/1/21/medline PY - 2003/3/12/entrez SP - 159 EP - 63 JF - Fitoterapia JO - Fitoterapia VL - 74 IS - 1-2 N2 - The extracts as well as piperolactum C, goniopedaline, 6beta-hydroxystigmasta-4,22-dien-3-one and a mixture of cis- and trans-4-hydroxymelleins obtained from Uvaria hamiltonii stem bark exhibited mild to moderate in vitro antibacterial activity. The results obtained were compared with a standard antibiotic, kanamycin. In a brine shrimp lethality bioassay the pet-ether, dichloromethane, methanol extracts and a major alkaloid, piperolactum C were found to exhibit mild to moderate cytotoxicity. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/12628415/Antibacterial_activity_and_cytotoxicity_of_extractives_from_Uvaria_hamiltonii_stem_bark_ DB - PRIME DP - Unbound Medicine ER -