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Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease.
J Alzheimers Dis. 2002 Dec; 4(6):517-22.JA

Abstract

Oxidative stress is believed to play a major role in the pathogenesis of Alzheimer disease (AD). Plasma concentrations of vitamins C, A and E, of uric acid, thiols and carotenoids were lower and of malondialdehyde (MDA) higher in 35 AD patients (85.9 +/- 5.5 y) compared to 40 controls 85.5 +/- 4.4 y). Differences were significant for vitamin C, vitamin E, lutein, lycopene, alpha-carotene and MDA (p < 0.001). Plasma exposed to peroxyl radicals showed a rate of antioxidant consumption and of MDA production higher in AD patients than in controls. AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure.

Authors+Show Affiliations

Institute of Physiological Chemistry I, Heinrich-Heine University, Düsseldorf, Germany. polidori@uni-duesseldorf.deNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12629261

Citation

Polidori, M Cristina, and Patrizia Mecocci. "Plasma Susceptibility to Free Radical-induced Antioxidant Consumption and Lipid Peroxidation Is Increased in Very Old Subjects With Alzheimer Disease." Journal of Alzheimer's Disease : JAD, vol. 4, no. 6, 2002, pp. 517-22.
Polidori MC, Mecocci P. Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis. 2002;4(6):517-22.
Polidori, M. C., & Mecocci, P. (2002). Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. Journal of Alzheimer's Disease : JAD, 4(6), 517-22.
Polidori MC, Mecocci P. Plasma Susceptibility to Free Radical-induced Antioxidant Consumption and Lipid Peroxidation Is Increased in Very Old Subjects With Alzheimer Disease. J Alzheimers Dis. 2002;4(6):517-22. PubMed PMID: 12629261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. AU - Polidori,M Cristina, AU - Mecocci,Patrizia, PY - 2003/3/12/pubmed PY - 2003/7/4/medline PY - 2003/3/12/entrez SP - 517 EP - 22 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 4 IS - 6 N2 - Oxidative stress is believed to play a major role in the pathogenesis of Alzheimer disease (AD). Plasma concentrations of vitamins C, A and E, of uric acid, thiols and carotenoids were lower and of malondialdehyde (MDA) higher in 35 AD patients (85.9 +/- 5.5 y) compared to 40 controls 85.5 +/- 4.4 y). Differences were significant for vitamin C, vitamin E, lutein, lycopene, alpha-carotene and MDA (p < 0.001). Plasma exposed to peroxyl radicals showed a rate of antioxidant consumption and of MDA production higher in AD patients than in controls. AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/12629261/Plasma_susceptibility_to_free_radical_induced_antioxidant_consumption_and_lipid_peroxidation_is_increased_in_very_old_subjects_with_Alzheimer_disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1387-2877&amp;volume=4&amp;issue=6&amp;spage=517 DB - PRIME DP - Unbound Medicine ER -