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Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease.
J Alzheimers Dis. 2002 Dec; 4(6):517-22.JA

Abstract

Oxidative stress is believed to play a major role in the pathogenesis of Alzheimer disease (AD). Plasma concentrations of vitamins C, A and E, of uric acid, thiols and carotenoids were lower and of malondialdehyde (MDA) higher in 35 AD patients (85.9 +/- 5.5 y) compared to 40 controls 85.5 +/- 4.4 y). Differences were significant for vitamin C, vitamin E, lutein, lycopene, alpha-carotene and MDA (p < 0.001). Plasma exposed to peroxyl radicals showed a rate of antioxidant consumption and of MDA production higher in AD patients than in controls. AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure.

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Authors+Show Affiliations

Polidori MC
Institute of Physiological Chemistry I, Heinrich-Heine University, Düsseldorf, Germany. polidori@uni-duesseldorf.de
Mecocci P
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseAntioxidantsBrainFemaleFree Radical ScavengersFree RadicalsHumansLipid PeroxidationMalondialdehydeOxidative StressReference Values

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12629261

Clinical Trial Links

Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease

Citation

Polidori, M Cristina, and Patrizia Mecocci. "Plasma Susceptibility to Free Radical-induced Antioxidant Consumption and Lipid Peroxidation Is Increased in Very Old Subjects With Alzheimer Disease." Journal of Alzheimer's Disease : JAD, vol. 4, no. 6, 2002, pp. 517-22.
Polidori MC, Mecocci P. Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis. 2002;4(6):517-22.
Polidori, M. C., & Mecocci, P. (2002). Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. Journal of Alzheimer's Disease : JAD, 4(6), 517-22.
Polidori MC, Mecocci P. Plasma Susceptibility to Free Radical-induced Antioxidant Consumption and Lipid Peroxidation Is Increased in Very Old Subjects With Alzheimer Disease. J Alzheimers Dis. 2002;4(6):517-22. PubMed PMID: 12629261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. AU - Polidori,M Cristina, AU - Mecocci,Patrizia, PY - 2003/3/12/pubmed PY - 2003/7/4/medline PY - 2003/3/12/entrez SP - 517 EP - 22 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 4 IS - 6 N2 - Oxidative stress is believed to play a major role in the pathogenesis of Alzheimer disease (AD). Plasma concentrations of vitamins C, A and E, of uric acid, thiols and carotenoids were lower and of malondialdehyde (MDA) higher in 35 AD patients (85.9 +/- 5.5 y) compared to 40 controls 85.5 +/- 4.4 y). Differences were significant for vitamin C, vitamin E, lutein, lycopene, alpha-carotene and MDA (p < 0.001). Plasma exposed to peroxyl radicals showed a rate of antioxidant consumption and of MDA production higher in AD patients than in controls. AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/12629261/Plasma_susceptibility_to_free_radical_induced_antioxidant_consumption_and_lipid_peroxidation_is_increased_in_very_old_subjects_with_Alzheimer_disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1387-2877&amp;volume=4&amp;issue=6&amp;spage=517 DB - PRIME DP - Unbound Medicine ER -