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Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia.
Hepatogastroenterology. 2003 Jan-Feb; 50(49):278-83.H

Abstract

BACKGROUND/AIMS

Although antidepressants have been used for decades in treating patients with functional abdominal syndromes, how they influence gastrointestinal motility remains unclear. We aimed to assess the role of depression in functional dyspepsia, and the effect of antidepressants on the functional dyspepsia patients' symptoms and gastric myoelectrical activity.

METHODOLOGY

We conducted an open clinical trial with 40 functional dyspepsia patients. Zung self-rating depression scale was used in evaluating the patients' depression. Cutaneous electrogastrography and evaluation of upper gastrointestinal symptoms were performed before and after administration of a one-month course of fluoxetine.

RESULTS

In the baseline study, the depressed functional dyspepsia patients had higher symptom scores than non-depressed patients (P < 0.05). The depressed functional dyspepsia patients had higher percentages of tachygastria than healthy controls (P < 0.05), but the electrogastrography parameters of depressed and non-depressed functional dyspepsia patients were not different. After one-month fluoxetine treatment, the symptom scores improved significantly in the depressed functional dyspepsia patients (P < 0.05), but not in the non-depressed patients. Electrogastrography did not improve in either group.

CONCLUSIONS

Depressive functional dyspepsia patients had higher symptom scores and responded well to fluoxetine treatment. However, electrogastrography did not improve after the treatment. These findings suggest that depression is significant in the presentation of functional dyspepsia symptoms, but not correlated with gastric myoelectrical activity.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, 160 Section 3, Taichung-Kang Road, Taichung, 407, Taiwan. chun@vghtc.vghtc.gov.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12630041

Citation

Wu, Chun-Ying, et al. "Effect of Fluoxetine On Symptoms and Gastric Dysrhythmia in Patients With Functional Dyspepsia." Hepato-gastroenterology, vol. 50, no. 49, 2003, pp. 278-83.
Wu CY, Chou LT, Chen HP, et al. Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia. Hepatogastroenterology. 2003;50(49):278-83.
Wu, C. Y., Chou, L. T., Chen, H. P., Chang, C. S., Wong, P. G., & Chen, G. H. (2003). Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia. Hepato-gastroenterology, 50(49), 278-83.
Wu CY, et al. Effect of Fluoxetine On Symptoms and Gastric Dysrhythmia in Patients With Functional Dyspepsia. Hepatogastroenterology. 2003 Jan-Feb;50(49):278-83. PubMed PMID: 12630041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fluoxetine on symptoms and gastric dysrhythmia in patients with functional dyspepsia. AU - Wu,Chun-Ying, AU - Chou,Lin-Tai, AU - Chen,Hsiao-Ping, AU - Chang,Chi-Sen, AU - Wong,Pei-Guan, AU - Chen,Gran-Hum, PY - 2003/3/13/pubmed PY - 2003/6/11/medline PY - 2003/3/13/entrez SP - 278 EP - 83 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 50 IS - 49 N2 - BACKGROUND/AIMS: Although antidepressants have been used for decades in treating patients with functional abdominal syndromes, how they influence gastrointestinal motility remains unclear. We aimed to assess the role of depression in functional dyspepsia, and the effect of antidepressants on the functional dyspepsia patients' symptoms and gastric myoelectrical activity. METHODOLOGY: We conducted an open clinical trial with 40 functional dyspepsia patients. Zung self-rating depression scale was used in evaluating the patients' depression. Cutaneous electrogastrography and evaluation of upper gastrointestinal symptoms were performed before and after administration of a one-month course of fluoxetine. RESULTS: In the baseline study, the depressed functional dyspepsia patients had higher symptom scores than non-depressed patients (P < 0.05). The depressed functional dyspepsia patients had higher percentages of tachygastria than healthy controls (P < 0.05), but the electrogastrography parameters of depressed and non-depressed functional dyspepsia patients were not different. After one-month fluoxetine treatment, the symptom scores improved significantly in the depressed functional dyspepsia patients (P < 0.05), but not in the non-depressed patients. Electrogastrography did not improve in either group. CONCLUSIONS: Depressive functional dyspepsia patients had higher symptom scores and responded well to fluoxetine treatment. However, electrogastrography did not improve after the treatment. These findings suggest that depression is significant in the presentation of functional dyspepsia symptoms, but not correlated with gastric myoelectrical activity. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/12630041/Effect_of_fluoxetine_on_symptoms_and_gastric_dysrhythmia_in_patients_with_functional_dyspepsia_ L2 - https://www.diseaseinfosearch.org/result/2394 DB - PRIME DP - Unbound Medicine ER -