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Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease.
Gut 2003; 52(4):464-70Gut

Abstract

BACKGROUND AND AIMS

The gamma-aminobutyric acid (GABA(B)) agonist baclofen has been shown to reduce reflux episodes during the first three postprandial hours in patients with gastro-oesophageal reflux disease (GORD) and in normal controls. The aim of the study was to assess the effect of acute (one day) and chronic (four weeks) administration of baclofen on 24 hour pH metry and symptoms in GORD patients and normal controls.

PATIENTS AND METHODS

Acute study: 28 patients with GORD with none or mild oesophagitis at endoscopy and 15 controls underwent oesophageal and gastric 48 hour pH metry in which baclofen or placebo was given for 24 hours in a double blinded manner. Chronic study: 16 GORD patients received baclofen (10 mg four times daily) or placebo for four weeks. Twenty four hour oesophageal pH metry and reflux symptom scores were evaluated before and at the end of treatment.

RESULTS

Acute study: the number of reflux episodes and per cent time with pH <4 was significantly lower after baclofen in GORD patients and controls (p<0.003; p<0.0007). Gastric pH increased significantly in GORD patients and controls (p<0.001; p<0.05). Chronic study: four weeks after initial administration of baclofen, the number of reflux episodes and percentage of time with pH <4 significantly decreased in all GORD patients (p<0.003; p<0.02). Symptom scores significantly improved after treatment with baclofen (p<0.0007).

CONCLUSIONS

The GABA(B) agonist baclofen reduces 24 hour gastro-oesophageal reflux and increases gastric pH in GORD patients and controls. When given for one month to GORD patients, baclofen reduces oesophageal acid refluxes and significantly improves symptoms. Baclofen may be useful in the therapy of GORD.

Authors+Show Affiliations

University G d' Annunzio, Chieti-Pescara, Italy.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12631652

Citation

Ciccaglione, A F., and L Marzio. "Effect of Acute and Chronic Administration of the GABA B Agonist Baclofen On 24 Hour pH Metry and Symptoms in Control Subjects and in Patients With Gastro-oesophageal Reflux Disease." Gut, vol. 52, no. 4, 2003, pp. 464-70.
Ciccaglione AF, Marzio L. Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease. Gut. 2003;52(4):464-70.
Ciccaglione, A. F., & Marzio, L. (2003). Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease. Gut, 52(4), pp. 464-70.
Ciccaglione AF, Marzio L. Effect of Acute and Chronic Administration of the GABA B Agonist Baclofen On 24 Hour pH Metry and Symptoms in Control Subjects and in Patients With Gastro-oesophageal Reflux Disease. Gut. 2003;52(4):464-70. PubMed PMID: 12631652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of acute and chronic administration of the GABA B agonist baclofen on 24 hour pH metry and symptoms in control subjects and in patients with gastro-oesophageal reflux disease. AU - Ciccaglione,A F, AU - Marzio,L, PY - 2003/3/13/pubmed PY - 2003/5/30/medline PY - 2003/3/13/entrez SP - 464 EP - 70 JF - Gut JO - Gut VL - 52 IS - 4 N2 - BACKGROUND AND AIMS: The gamma-aminobutyric acid (GABA(B)) agonist baclofen has been shown to reduce reflux episodes during the first three postprandial hours in patients with gastro-oesophageal reflux disease (GORD) and in normal controls. The aim of the study was to assess the effect of acute (one day) and chronic (four weeks) administration of baclofen on 24 hour pH metry and symptoms in GORD patients and normal controls. PATIENTS AND METHODS: Acute study: 28 patients with GORD with none or mild oesophagitis at endoscopy and 15 controls underwent oesophageal and gastric 48 hour pH metry in which baclofen or placebo was given for 24 hours in a double blinded manner. Chronic study: 16 GORD patients received baclofen (10 mg four times daily) or placebo for four weeks. Twenty four hour oesophageal pH metry and reflux symptom scores were evaluated before and at the end of treatment. RESULTS: Acute study: the number of reflux episodes and per cent time with pH <4 was significantly lower after baclofen in GORD patients and controls (p<0.003; p<0.0007). Gastric pH increased significantly in GORD patients and controls (p<0.001; p<0.05). Chronic study: four weeks after initial administration of baclofen, the number of reflux episodes and percentage of time with pH <4 significantly decreased in all GORD patients (p<0.003; p<0.02). Symptom scores significantly improved after treatment with baclofen (p<0.0007). CONCLUSIONS: The GABA(B) agonist baclofen reduces 24 hour gastro-oesophageal reflux and increases gastric pH in GORD patients and controls. When given for one month to GORD patients, baclofen reduces oesophageal acid refluxes and significantly improves symptoms. Baclofen may be useful in the therapy of GORD. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/12631652/Effect_of_acute_and_chronic_administration_of_the_GABA_B_agonist_baclofen_on_24_hour_pH_metry_and_symptoms_in_control_subjects_and_in_patients_with_gastro_oesophageal_reflux_disease_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=12631652 DB - PRIME DP - Unbound Medicine ER -