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Comparison of three antigen detection tests for diagnosis and follow-up of falciparum malaria in travellers returning to Berlin, Germany.
Parasitol Res. 2003 Mar; 89(5):354-7.PR

Abstract

We determined the sensitivity and specificity of three rapid immunochromatographic malarial antigen detection test systems (RDTs) for the detection of Plasmodium falciparumand assessed the quality of follow-up results. ParaSight-F and ICT Malaria detect histidine-rich protein-2 (HRP-2), whereas OptiMal detects plasmodial lactate dehydrogenase (pLDH). ParaSight-F performed with 95.1% sensitivity and 97.1% specificity (554 patients tested of whom 144 had falciparum malaria). ICT Malaria performed with 95.7% sensitivity and 99.2% specificity (718 patients tested of whom 184 had falciparum malaria). OptiMal performed with 76.2% sensitivity and 99.7% specificity (539 patients tested of whom 130 had falciparum malaria). In follow-up investigations, HRP-2 did not appear to be a useful antigen due to its long half-life, whereas pLDH offers a reasonable correlation with the presence of viable parasites in those cases initially detected. We therefore conclude that a combination of both antigens might be the best option for creating a reliable RDT for the diagnosis of falciparum malaria.

Authors+Show Affiliations

Grobusch MP
Department of Parasitology, Institute of Tropical Medicine, Eberhard Karls University, Wilhelmstrasse 27, 72074 Tuebingen, Germany. martin.grobusch@uni-tuebingen.de
Hänscheid T
No affiliation info available
Göbels K
No affiliation info available
Slevogt H
No affiliation info available
Zoller T
No affiliation info available
Rögler G
No affiliation info available
Teichmann D
No affiliation info available

MeSH

AnimalsAntigens, ProtozoanBerlinCohort StudiesFollow-Up StudiesHumansMalaria, FalciparumMicroscopyPlasmodium falciparumPredictive Value of TestsReagent Kits, DiagnosticSensitivity and Specificity

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12632146

Citation

Grobusch, Martin P., et al. "Comparison of Three Antigen Detection Tests for Diagnosis and Follow-up of Falciparum Malaria in Travellers Returning to Berlin, Germany." Parasitology Research, vol. 89, no. 5, 2003, pp. 354-7.
Grobusch MP, Hänscheid T, Göbels K, et al. Comparison of three antigen detection tests for diagnosis and follow-up of falciparum malaria in travellers returning to Berlin, Germany. Parasitol Res. 2003;89(5):354-7.
Grobusch, M. P., Hänscheid, T., Göbels, K., Slevogt, H., Zoller, T., Rögler, G., & Teichmann, D. (2003). Comparison of three antigen detection tests for diagnosis and follow-up of falciparum malaria in travellers returning to Berlin, Germany. Parasitology Research, 89(5), 354-7.
Grobusch MP, et al. Comparison of Three Antigen Detection Tests for Diagnosis and Follow-up of Falciparum Malaria in Travellers Returning to Berlin, Germany. Parasitol Res. 2003;89(5):354-7. PubMed PMID: 12632146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of three antigen detection tests for diagnosis and follow-up of falciparum malaria in travellers returning to Berlin, Germany. AU - Grobusch,Martin P, AU - Hänscheid,Thomas, AU - Göbels,Klaus, AU - Slevogt,Hortense, AU - Zoller,Thomas, AU - Rögler,Gertrud, AU - Teichmann,Dieter, Y1 - 2002/11/22/ PY - 2002/08/30/received PY - 2003/3/13/pubmed PY - 2003/6/14/medline PY - 2003/3/13/entrez SP - 354 EP - 7 JF - Parasitology research JO - Parasitol Res VL - 89 IS - 5 N2 - We determined the sensitivity and specificity of three rapid immunochromatographic malarial antigen detection test systems (RDTs) for the detection of Plasmodium falciparumand assessed the quality of follow-up results. ParaSight-F and ICT Malaria detect histidine-rich protein-2 (HRP-2), whereas OptiMal detects plasmodial lactate dehydrogenase (pLDH). ParaSight-F performed with 95.1% sensitivity and 97.1% specificity (554 patients tested of whom 144 had falciparum malaria). ICT Malaria performed with 95.7% sensitivity and 99.2% specificity (718 patients tested of whom 184 had falciparum malaria). OptiMal performed with 76.2% sensitivity and 99.7% specificity (539 patients tested of whom 130 had falciparum malaria). In follow-up investigations, HRP-2 did not appear to be a useful antigen due to its long half-life, whereas pLDH offers a reasonable correlation with the presence of viable parasites in those cases initially detected. We therefore conclude that a combination of both antigens might be the best option for creating a reliable RDT for the diagnosis of falciparum malaria. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/12632146/Comparison_of_three_antigen_detection_tests_for_diagnosis_and_follow_up_of_falciparum_malaria_in_travellers_returning_to_Berlin_Germany_ DB - PRIME DP - Unbound Medicine ER -