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Urinary supersaturation with calcium oxalate before and during orthophosphate therapy.

Abstract

The concentrations of sodium, potassium, calcium, magnesium, phosphorus, sulfate, citrate and oxalate in the urine of normal subjects were compared to the concentrations in urine of calcium oxalate stone-forming patients. Because of the large volume excreted by stone-forming patients the urine contained less concentrations of sodium, potassium, magnesium, phosphorus, sulfate and citrate than did the urine from normal subjects. The urinary concentrations of calcium and oxalate were similar in the 2 groups and, thus, the calculated supersaturation of calcium oxalate was greater in the urine of stone-forming patients than in the urine of normal subjects. Orthophosphate therapy increased the urinary concentration of alkali ions and phosphate but reduced urinary calcium concentration, thereby causing a reduction in urine supersaturation with calcium oxalate. There was no discernible correlation between the phosphate-induced changes in urine supersaturation and the presence or absence of continued calculus formation.

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  • Publisher Full Text
  • Authors

    , ,

    Source

    The Journal of urology 115:4 1976 Apr pg 418-22

    MeSH

    Calcium
    Humans
    Male
    Middle Aged
    Oxalates
    Phosphates
    Urinary Calculi

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    1263318

    Citation

    Burdette, D C., et al. "Urinary Supersaturation With Calcium Oxalate Before and During Orthophosphate Therapy." The Journal of Urology, vol. 115, no. 4, 1976, pp. 418-22.
    Burdette DC, Thomas WC, Finlayson B. Urinary supersaturation with calcium oxalate before and during orthophosphate therapy. J Urol. 1976;115(4):418-22.
    Burdette, D. C., Thomas, W. C., & Finlayson, B. (1976). Urinary supersaturation with calcium oxalate before and during orthophosphate therapy. The Journal of Urology, 115(4), pp. 418-22.
    Burdette DC, Thomas WC, Finlayson B. Urinary Supersaturation With Calcium Oxalate Before and During Orthophosphate Therapy. J Urol. 1976;115(4):418-22. PubMed PMID: 1263318.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Urinary supersaturation with calcium oxalate before and during orthophosphate therapy. AU - Burdette,D C, AU - Thomas,W C,Jr AU - Finlayson,B, PY - 1976/4/11/pubmed PY - 2001/3/28/medline PY - 1976/4/11/entrez SP - 418 EP - 22 JF - The Journal of urology JO - J. Urol. VL - 115 IS - 4 N2 - The concentrations of sodium, potassium, calcium, magnesium, phosphorus, sulfate, citrate and oxalate in the urine of normal subjects were compared to the concentrations in urine of calcium oxalate stone-forming patients. Because of the large volume excreted by stone-forming patients the urine contained less concentrations of sodium, potassium, magnesium, phosphorus, sulfate and citrate than did the urine from normal subjects. The urinary concentrations of calcium and oxalate were similar in the 2 groups and, thus, the calculated supersaturation of calcium oxalate was greater in the urine of stone-forming patients than in the urine of normal subjects. Orthophosphate therapy increased the urinary concentration of alkali ions and phosphate but reduced urinary calcium concentration, thereby causing a reduction in urine supersaturation with calcium oxalate. There was no discernible correlation between the phosphate-induced changes in urine supersaturation and the presence or absence of continued calculus formation. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/1263318/Urinary_supersaturation_with_calcium_oxalate_before_and_during_orthophosphate_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(17)59224-1 DB - PRIME DP - Unbound Medicine ER -