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Body composition, bone mineral density, and circulating leptin levels in postmenopausal Turkish women.
Rheumatol Int 2003; 23(2):87-91RI

Abstract

OBJECTIVE

We analyzed the relationship between serum leptin levels and bone mineral density (BMD) values as well as the relationship between serum leptin levels and whole body composition, whether or not they were associated. In addition, we also investigated whether lean mass or fat mass is a better predictor of BMD in postmenopausal Turkish women.

DESIGN AND MEASUREMENTS

One hundred consecutive postmenopausal women with a mean age of 55.1 +/- 6.3 years who visited our outpatient clinic for the evaluation of osteoporosis were recruited. Skin fold thickness at four sites and waist:hip ratio were measured. Body mass index (BMI) was calculated in kg/m(2). Serum concentrations of leptin, insulin, and estradiol were evaluated. Bone formation and resorption markers were also determined. The BMD values were measured by dual energy X-ray absorptiometry (DEXA) at the lumbar spine and femoral neck. Whole body composition (lean mass, fat mass, and percentage of fat), total bone mineral content (BMC) in g, and total BMD were also measured by DEXA.

RESULTS

Serum leptin levels did not correlate with BMD values at all skeleton sites measured. Leptin correlated positively with fat mass, percentage of fat, and BMI (r = 0.738 and P = 0.00, r = 0.536 and P = 0.00, r = 0.356 and P = 0.00, respectively). Lean mass correlated with BMD at all sites measured (r = 0.339 and P = 0.00, r = 0.312 and P = 0.01, r = 0.523 and P = 0.00, r = 0.636 and P = 0.00). Lean mass correlated with BMI (r = 0.636, P = 0.00) but not with serum leptin (r = -0.021, P = 0.881), and it was an independent determinant of BMD at all skeleton sites measured.

CONCLUSION

Our study showed that lean mass is a better predictor than fat mass of bone mineral density and that serum leptin levels are not associated with BMD.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Mersin University, School of Medicine, Mersin, Turkey. gunsahsahin@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12634942

Citation

Sahin, Günşah, et al. "Body Composition, Bone Mineral Density, and Circulating Leptin Levels in Postmenopausal Turkish Women." Rheumatology International, vol. 23, no. 2, 2003, pp. 87-91.
Sahin G, Polat G, Baethiş S, et al. Body composition, bone mineral density, and circulating leptin levels in postmenopausal Turkish women. Rheumatol Int. 2003;23(2):87-91.
Sahin, G., Polat, G., Baethiş, S., Milcan, A., Baethdatoethlu, O., Erdoethan, C., & Camdeviren, H. (2003). Body composition, bone mineral density, and circulating leptin levels in postmenopausal Turkish women. Rheumatology International, 23(2), pp. 87-91.
Sahin G, et al. Body Composition, Bone Mineral Density, and Circulating Leptin Levels in Postmenopausal Turkish Women. Rheumatol Int. 2003;23(2):87-91. PubMed PMID: 12634942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body composition, bone mineral density, and circulating leptin levels in postmenopausal Turkish women. AU - Sahin,Günşah, AU - Polat,Gürbüz, AU - Baethiş,Selda, AU - Milcan,Abdullah, AU - Baethdatoethlu,Ozden, AU - Erdoethan,Canan, AU - Camdeviren,Handan, Y1 - 2002/10/23/ PY - 2002/05/15/received PY - 2002/08/26/accepted PY - 2003/3/14/pubmed PY - 2003/9/17/medline PY - 2003/3/14/entrez SP - 87 EP - 91 JF - Rheumatology international JO - Rheumatol. Int. VL - 23 IS - 2 N2 - OBJECTIVE: We analyzed the relationship between serum leptin levels and bone mineral density (BMD) values as well as the relationship between serum leptin levels and whole body composition, whether or not they were associated. In addition, we also investigated whether lean mass or fat mass is a better predictor of BMD in postmenopausal Turkish women. DESIGN AND MEASUREMENTS: One hundred consecutive postmenopausal women with a mean age of 55.1 +/- 6.3 years who visited our outpatient clinic for the evaluation of osteoporosis were recruited. Skin fold thickness at four sites and waist:hip ratio were measured. Body mass index (BMI) was calculated in kg/m(2). Serum concentrations of leptin, insulin, and estradiol were evaluated. Bone formation and resorption markers were also determined. The BMD values were measured by dual energy X-ray absorptiometry (DEXA) at the lumbar spine and femoral neck. Whole body composition (lean mass, fat mass, and percentage of fat), total bone mineral content (BMC) in g, and total BMD were also measured by DEXA. RESULTS: Serum leptin levels did not correlate with BMD values at all skeleton sites measured. Leptin correlated positively with fat mass, percentage of fat, and BMI (r = 0.738 and P = 0.00, r = 0.536 and P = 0.00, r = 0.356 and P = 0.00, respectively). Lean mass correlated with BMD at all sites measured (r = 0.339 and P = 0.00, r = 0.312 and P = 0.01, r = 0.523 and P = 0.00, r = 0.636 and P = 0.00). Lean mass correlated with BMI (r = 0.636, P = 0.00) but not with serum leptin (r = -0.021, P = 0.881), and it was an independent determinant of BMD at all skeleton sites measured. CONCLUSION: Our study showed that lean mass is a better predictor than fat mass of bone mineral density and that serum leptin levels are not associated with BMD. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/12634942/Body_composition_bone_mineral_density_and_circulating_leptin_levels_in_postmenopausal_Turkish_women_ L2 - https://dx.doi.org/10.1007/s00296-002-0257-0 DB - PRIME DP - Unbound Medicine ER -