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Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days.
Physiol Meas. 2003 Feb; 24(1):107-19.PM

Abstract

A study of the concentrations of the common breath metabolites ammonia, acetone, isoprene, ethanol and acetaldehyde in the breath of five subjects over a period of 30 days has been carried out. Breath samples were taken and analysed in the early morning on arrival at the laboratory. The real time analyses of three consecutive breath exhalations were carried out using selected ion flow tube mass spectrometry (SIFT-MS) on line to the instrument. Sufficient data were obtained to allow meaningful concentration distributions to be obtained for ammonia, acetone, isoprene and ethanol. These showed that the ammonia, acetone and isoprene concentrations exhibited sensibly normal distributions, with coefficients of variation of typically 0.3. Obvious and statistically significant (p < 0.01) differences are apparent in the mean concentrations of these metabolites between the five individuals. The acetaldehyde concentrations were relatively low and close to the instrument detection limit, and the differences between the mean concentrations of the five subjects were not statistically significant (p = 0.4), so distributions were not obtained. The mean concentrations, in parts per billion (ppb), of each metabolite range amongst the five subjects are as follows: ammonia, 422-2389: acetone, 293-870; isoprene, 55-121; ethanol, 27-153; acetaldehyde, 2-5. There are no obvious patterns in the distributions of these particular metabolites for these individuals, except that the ammonia levels were greatest in the breath of the two oldest subjects.

Authors+Show Affiliations

Centre for Science and Technology in Medicine, School of Postgraduate Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12636190

Citation

Diskin, Ann M., et al. "Time Variation of Ammonia, Acetone, Isoprene and Ethanol in Breath: a Quantitative SIFT-MS Study Over 30 Days." Physiological Measurement, vol. 24, no. 1, 2003, pp. 107-19.
Diskin AM, Spanel P, Smith D. Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days. Physiol Meas. 2003;24(1):107-19.
Diskin, A. M., Spanel, P., & Smith, D. (2003). Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days. Physiological Measurement, 24(1), 107-19.
Diskin AM, Spanel P, Smith D. Time Variation of Ammonia, Acetone, Isoprene and Ethanol in Breath: a Quantitative SIFT-MS Study Over 30 Days. Physiol Meas. 2003;24(1):107-19. PubMed PMID: 12636190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days. AU - Diskin,Ann M, AU - Spanel,Patrik, AU - Smith,David, PY - 2003/3/15/pubmed PY - 2003/10/16/medline PY - 2003/3/15/entrez SP - 107 EP - 19 JF - Physiological measurement JO - Physiol Meas VL - 24 IS - 1 N2 - A study of the concentrations of the common breath metabolites ammonia, acetone, isoprene, ethanol and acetaldehyde in the breath of five subjects over a period of 30 days has been carried out. Breath samples were taken and analysed in the early morning on arrival at the laboratory. The real time analyses of three consecutive breath exhalations were carried out using selected ion flow tube mass spectrometry (SIFT-MS) on line to the instrument. Sufficient data were obtained to allow meaningful concentration distributions to be obtained for ammonia, acetone, isoprene and ethanol. These showed that the ammonia, acetone and isoprene concentrations exhibited sensibly normal distributions, with coefficients of variation of typically 0.3. Obvious and statistically significant (p < 0.01) differences are apparent in the mean concentrations of these metabolites between the five individuals. The acetaldehyde concentrations were relatively low and close to the instrument detection limit, and the differences between the mean concentrations of the five subjects were not statistically significant (p = 0.4), so distributions were not obtained. The mean concentrations, in parts per billion (ppb), of each metabolite range amongst the five subjects are as follows: ammonia, 422-2389: acetone, 293-870; isoprene, 55-121; ethanol, 27-153; acetaldehyde, 2-5. There are no obvious patterns in the distributions of these particular metabolites for these individuals, except that the ammonia levels were greatest in the breath of the two oldest subjects. SN - 0967-3334 UR - https://www.unboundmedicine.com/medline/citation/12636190/Time_variation_of_ammonia_acetone_isoprene_and_ethanol_in_breath:_a_quantitative_SIFT_MS_study_over_30_days_ L2 - https://doi.org/10.1088/0967-3334/24/1/308 DB - PRIME DP - Unbound Medicine ER -