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The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances.
Clin Chim Acta 2003; 330(1-2):57-83CC

Abstract

BACKGROUND

Dietary modifications to prevent prostate cancer (PCa) continue to gain attention as research demonstrates that various dietary nutrients/supplements are related to decreased risk of developing prostate cancer (PCa). Several studies have focused on the antioxidant and nonantioxidant effects of various dietary substances in the prevention of PCa. Research into the mechanisms by which PCa is prevented, or its disease severity is reduced by dietary micronutrients and vitamins continues to enrich our understanding of the mechanisms by which PCa is initiated and progresses.

METHODS

We reviewed the literature on dietary nutrients with antioxidant properties that have been shown to have a positive effect in reducing the incidence or preventing the occurrence of PCa including carotenoids (e.g., lycopene), retinoids (e.g., vitamin A), vitamin E, vitamin C, selenium, and polyphenols. Other nutrients examined included vitamin D and calcium.

RESULTS

Many dietary micronutrients have demonstrated significant and complex effects on PCa cell proliferation, differentiation, and signaling related to the initiation, progression, and regression of PCa.

CONCLUSION

Understanding the mechanisms by which various dietary nutrients exert their effects on PCa may make it possible to design effective drugs for treating PCa and to promote better nutrition and lifestyle changes in those at risk for PCa.

Authors+Show Affiliations

Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, USA. mwilli@parknet.pmh.orgNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12636926

Citation

Willis, Monte S., and Frank H. Wians. "The Role of Nutrition in Preventing Prostate Cancer: a Review of the Proposed Mechanism of Action of Various Dietary Substances." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 330, no. 1-2, 2003, pp. 57-83.
Willis MS, Wians FH. The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin Chim Acta. 2003;330(1-2):57-83.
Willis, M. S., & Wians, F. H. (2003). The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clinica Chimica Acta; International Journal of Clinical Chemistry, 330(1-2), pp. 57-83.
Willis MS, Wians FH. The Role of Nutrition in Preventing Prostate Cancer: a Review of the Proposed Mechanism of Action of Various Dietary Substances. Clin Chim Acta. 2003;330(1-2):57-83. PubMed PMID: 12636926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. AU - Willis,Monte S, AU - Wians,Frank H, PY - 2003/3/15/pubmed PY - 2003/12/3/medline PY - 2003/3/15/entrez SP - 57 EP - 83 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 330 IS - 1-2 N2 - BACKGROUND: Dietary modifications to prevent prostate cancer (PCa) continue to gain attention as research demonstrates that various dietary nutrients/supplements are related to decreased risk of developing prostate cancer (PCa). Several studies have focused on the antioxidant and nonantioxidant effects of various dietary substances in the prevention of PCa. Research into the mechanisms by which PCa is prevented, or its disease severity is reduced by dietary micronutrients and vitamins continues to enrich our understanding of the mechanisms by which PCa is initiated and progresses. METHODS: We reviewed the literature on dietary nutrients with antioxidant properties that have been shown to have a positive effect in reducing the incidence or preventing the occurrence of PCa including carotenoids (e.g., lycopene), retinoids (e.g., vitamin A), vitamin E, vitamin C, selenium, and polyphenols. Other nutrients examined included vitamin D and calcium. RESULTS: Many dietary micronutrients have demonstrated significant and complex effects on PCa cell proliferation, differentiation, and signaling related to the initiation, progression, and regression of PCa. CONCLUSION: Understanding the mechanisms by which various dietary nutrients exert their effects on PCa may make it possible to design effective drugs for treating PCa and to promote better nutrition and lifestyle changes in those at risk for PCa. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/12636926/The_role_of_nutrition_in_preventing_prostate_cancer:_a_review_of_the_proposed_mechanism_of_action_of_various_dietary_substances_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009898103000482 DB - PRIME DP - Unbound Medicine ER -