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Vitamin D: more than a "bone-a-fide" hormone.
Mol Endocrinol. 2003 May; 17(5):777-91.ME

Abstract

The vitamin D endocrine system is critical for the proper development and maintenance of mineral ion homeostasis and skeletal integrity. Beyond these classical roles, recent evidence suggests that the bioactive metabolite of vitamin D, 1,25-dihydroxyvitamin D3, functions in diverse physiological processes, such as hair follicle cycling, blood pressure regulation, and mammary gland development. This minireview explores the current progress in unraveling the complexities of the vitamin D endocrine system by focusing on four main areas of research: the resolution of the vitamin D receptor crystal structure, the molecular details of 1,25-dihydroxyvitamin D3-mediated transcription, murine knockout models of key genes in the endocrine system, and alternative vitamin D receptors and ligands.

Authors+Show Affiliations

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12637589

Citation

Sutton, Amelia L M., and Paul N. MacDonald. "Vitamin D: More Than a "bone-a-fide" Hormone." Molecular Endocrinology (Baltimore, Md.), vol. 17, no. 5, 2003, pp. 777-91.
Sutton AL, MacDonald PN. Vitamin D: more than a "bone-a-fide" hormone. Mol Endocrinol. 2003;17(5):777-91.
Sutton, A. L., & MacDonald, P. N. (2003). Vitamin D: more than a "bone-a-fide" hormone. Molecular Endocrinology (Baltimore, Md.), 17(5), 777-91.
Sutton AL, MacDonald PN. Vitamin D: More Than a "bone-a-fide" Hormone. Mol Endocrinol. 2003;17(5):777-91. PubMed PMID: 12637589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D: more than a "bone-a-fide" hormone. AU - Sutton,Amelia L M, AU - MacDonald,Paul N, Y1 - 2003/03/13/ PY - 2003/3/15/pubmed PY - 2004/6/18/medline PY - 2003/3/15/entrez SP - 777 EP - 91 JF - Molecular endocrinology (Baltimore, Md.) JO - Mol. Endocrinol. VL - 17 IS - 5 N2 - The vitamin D endocrine system is critical for the proper development and maintenance of mineral ion homeostasis and skeletal integrity. Beyond these classical roles, recent evidence suggests that the bioactive metabolite of vitamin D, 1,25-dihydroxyvitamin D3, functions in diverse physiological processes, such as hair follicle cycling, blood pressure regulation, and mammary gland development. This minireview explores the current progress in unraveling the complexities of the vitamin D endocrine system by focusing on four main areas of research: the resolution of the vitamin D receptor crystal structure, the molecular details of 1,25-dihydroxyvitamin D3-mediated transcription, murine knockout models of key genes in the endocrine system, and alternative vitamin D receptors and ligands. SN - 0888-8809 UR - https://www.unboundmedicine.com/medline/citation/12637589/Vitamin_D:_more_than_a_"bone_a_fide"_hormone_ L2 - https://academic.oup.com/mend/article-lookup/doi/10.1210/me.2002-0363 DB - PRIME DP - Unbound Medicine ER -