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High-density lipoprotein cholesterol and risk of stroke in Japanese men and women: the Oyabe Study.
Stroke 2003; 34(4):863-8S

Abstract

BACKGROUND AND PURPOSE

Evidence of an inverse relationship between serum high-density lipoprotein cholesterol (HDL-C) and the risk of stroke is sparse in Asians and in women. The purpose of this investigation was to examine the relationship in a long-term cohort study of Japanese men and women among whom stroke occurrence is higher than in Western countries.

METHODS

A prospective cohort study was performed involving 4989 participants (1523 men, 3466 women) 35 to 79 years of age at baseline with approximately 10 years of follow-up in a rural area of Japan. End points included all stroke incidence and ischemic stroke incidence.

RESULTS

During follow-up, 132 participants developed stroke, including 81 ischemic stroke cases. Age-adjusted incidence rates per 10,000 person-years for all stroke in subjects with low HDL-C (<30 mg/dL [0.78 mmol/L]) were 103.4 in men and 49.3 in women, which were remarkably higher than in subjects with high HDL-C (>or=60 mg/dL [1.56 mmol/L]) (26.4 in men and 15.5 in women). A similar relationship was observed for ischemic stroke. Multivariate-adjusted relative risks for all stroke incidence and ischemic stroke incidence were 2.89 (95% CI, 1.35 to 6.20) and 2.92 (95% CI, 1.17 to 7.32), respectively, for low versus high HDL-C participants. The relationships were independent of sex, age, body mass index, blood pressure, serum total cholesterol, alcohol consumption, and smoking.

CONCLUSIONS

This 10-year follow-up study of Japanese men and women demonstrated that lower HDL-C levels were related significantly and independently to increased risk of all stroke incidence and ischemic stroke incidence.

Authors+Show Affiliations

Department of Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. ysoyama@kanazawa-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12637692

Citation

Soyama, Yoshiyuki, et al. "High-density Lipoprotein Cholesterol and Risk of Stroke in Japanese Men and Women: the Oyabe Study." Stroke, vol. 34, no. 4, 2003, pp. 863-8.
Soyama Y, Miura K, Morikawa Y, et al. High-density lipoprotein cholesterol and risk of stroke in Japanese men and women: the Oyabe Study. Stroke. 2003;34(4):863-8.
Soyama, Y., Miura, K., Morikawa, Y., Nishijo, M., Nakanishi, Y., Naruse, Y., ... Nakagawa, H. (2003). High-density lipoprotein cholesterol and risk of stroke in Japanese men and women: the Oyabe Study. Stroke, 34(4), pp. 863-8.
Soyama Y, et al. High-density Lipoprotein Cholesterol and Risk of Stroke in Japanese Men and Women: the Oyabe Study. Stroke. 2003;34(4):863-8. PubMed PMID: 12637692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-density lipoprotein cholesterol and risk of stroke in Japanese men and women: the Oyabe Study. AU - Soyama,Yoshiyuki, AU - Miura,Katsuyuki, AU - Morikawa,Yuko, AU - Nishijo,Muneko, AU - Nakanishi,Yumiko, AU - Naruse,Yuchi, AU - Kagamimori,Sadanobu, AU - Nakagawa,Hideaki, AU - ,, Y1 - 2003/03/13/ PY - 2003/3/15/pubmed PY - 2003/4/25/medline PY - 2003/3/15/entrez SP - 863 EP - 8 JF - Stroke JO - Stroke VL - 34 IS - 4 N2 - BACKGROUND AND PURPOSE: Evidence of an inverse relationship between serum high-density lipoprotein cholesterol (HDL-C) and the risk of stroke is sparse in Asians and in women. The purpose of this investigation was to examine the relationship in a long-term cohort study of Japanese men and women among whom stroke occurrence is higher than in Western countries. METHODS: A prospective cohort study was performed involving 4989 participants (1523 men, 3466 women) 35 to 79 years of age at baseline with approximately 10 years of follow-up in a rural area of Japan. End points included all stroke incidence and ischemic stroke incidence. RESULTS: During follow-up, 132 participants developed stroke, including 81 ischemic stroke cases. Age-adjusted incidence rates per 10,000 person-years for all stroke in subjects with low HDL-C (<30 mg/dL [0.78 mmol/L]) were 103.4 in men and 49.3 in women, which were remarkably higher than in subjects with high HDL-C (>or=60 mg/dL [1.56 mmol/L]) (26.4 in men and 15.5 in women). A similar relationship was observed for ischemic stroke. Multivariate-adjusted relative risks for all stroke incidence and ischemic stroke incidence were 2.89 (95% CI, 1.35 to 6.20) and 2.92 (95% CI, 1.17 to 7.32), respectively, for low versus high HDL-C participants. The relationships were independent of sex, age, body mass index, blood pressure, serum total cholesterol, alcohol consumption, and smoking. CONCLUSIONS: This 10-year follow-up study of Japanese men and women demonstrated that lower HDL-C levels were related significantly and independently to increased risk of all stroke incidence and ischemic stroke incidence. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/12637692/High_density_lipoprotein_cholesterol_and_risk_of_stroke_in_Japanese_men_and_women:_the_Oyabe_Study_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000060869.34009.38?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -