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Soy isoflavones: a safety review.
Nutr Rev 2003; 61(1):1-33NR

Abstract

Soy isoflavones have been a component of the diet of certain populations for centuries. The consumption of soy generally has been considered beneficial, with a potentially protective effect against a number of chronic diseases; because of their estrogenic activity, however, negative effects of isoflavones have been postulated. This review examines the literature associated with the safety of soy isoflavones, including dietary soy isoflavone exposure data of populations with high soy intakes, human studies in which soy protein or isoflavones were provided, and toxicologic studies investigating the potential genotoxicity, carcinogenicity, and reproductive and developmental toxicity of soy isoflavones. Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12638461

Citation

Munro, Ian C., et al. "Soy Isoflavones: a Safety Review." Nutrition Reviews, vol. 61, no. 1, 2003, pp. 1-33.
Munro IC, Harwood M, Hlywka JJ, et al. Soy isoflavones: a safety review. Nutr Rev. 2003;61(1):1-33.
Munro, I. C., Harwood, M., Hlywka, J. J., Stephen, A. M., Doull, J., Flamm, W. G., & Adlercreutz, H. (2003). Soy isoflavones: a safety review. Nutrition Reviews, 61(1), pp. 1-33.
Munro IC, et al. Soy Isoflavones: a Safety Review. Nutr Rev. 2003;61(1):1-33. PubMed PMID: 12638461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones: a safety review. AU - Munro,Ian C, AU - Harwood,Melody, AU - Hlywka,Jason J, AU - Stephen,Alison M, AU - Doull,John, AU - Flamm,W Gary, AU - Adlercreutz,Herman, PY - 2003/3/18/pubmed PY - 2003/4/16/medline PY - 2003/3/18/entrez SP - 1 EP - 33 JF - Nutrition reviews JO - Nutr. Rev. VL - 61 IS - 1 N2 - Soy isoflavones have been a component of the diet of certain populations for centuries. The consumption of soy generally has been considered beneficial, with a potentially protective effect against a number of chronic diseases; because of their estrogenic activity, however, negative effects of isoflavones have been postulated. This review examines the literature associated with the safety of soy isoflavones, including dietary soy isoflavone exposure data of populations with high soy intakes, human studies in which soy protein or isoflavones were provided, and toxicologic studies investigating the potential genotoxicity, carcinogenicity, and reproductive and developmental toxicity of soy isoflavones. Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products. SN - 0029-6643 UR - https://www.unboundmedicine.com/medline/citation/12638461/Soy_isoflavones:_a_safety_review_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1301/nr.2003.janr.1-33 DB - PRIME DP - Unbound Medicine ER -