Tags

Type your tag names separated by a space and hit enter

Effect of caffeine on aortic elastic properties and wave reflection.
J Hypertens 2003; 21(3):563-70JH

Abstract

OBJECTIVE

Caffeine is the most widely used pharmacologically active substance. Aortic elastic properties and arterial wave reflection are important factors for the efficient performance of the cardiovascular system, as well as prognosticators of cardiovascular risk. We investigated the effect of caffeine on aortic elastic properties and wave reflection.

DESIGN

We studied the effect of caffeine (250 mg) in 20 healthy subjects according to a randomized, placebo-controlled, double-blind, cross-over design.

METHODS

Aortic stiffness was evaluated with carotid-femoral pulse wave velocity and wave reflection with augmentation index of the aortic pressure waveform.

RESULTS

Pulse wave velocity increased (by 0.51 m/s, 0.001) denoting an increase in aortic stiffness. Augmentation index and augmented pressure increased (by 6.8%, and by 4.4 mmHg, respectively, P <0.001 for both) denoting increased wave reflections. Concurrently, both radial and aortic systolic, diastolic and pulse pressure increased significantly. However, this increase was 20 and 9% larger for aortic systolic pressure (at 30 and 60 min, P <0.001 and P <0.05, respectively) and 56% larger for aortic pulse pressure (at 30 min, P <0.001) compared with the corresponding upper limb values. This indicates that peripheral pressure measurements are not an accurate guide for the pressor effect of caffeine in central arteries.

CONCLUSIONS

Caffeine affects unfavorably aortic stiffness and enhances wave reflections. This finding has implications for the impact of caffeine consumption on cardiovascular risk.

Authors+Show Affiliations

Medical Professorial Unit, St. Vincent's Hospital and Clinic, University of New South Wales, Sydney, Australia. cvlachop@otenet.grNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12640250

Citation

Vlachopoulos, Charalambos, et al. "Effect of Caffeine On Aortic Elastic Properties and Wave Reflection." Journal of Hypertension, vol. 21, no. 3, 2003, pp. 563-70.
Vlachopoulos C, Hirata K, O'Rourke MF. Effect of caffeine on aortic elastic properties and wave reflection. J Hypertens. 2003;21(3):563-70.
Vlachopoulos, C., Hirata, K., & O'Rourke, M. F. (2003). Effect of caffeine on aortic elastic properties and wave reflection. Journal of Hypertension, 21(3), pp. 563-70.
Vlachopoulos C, Hirata K, O'Rourke MF. Effect of Caffeine On Aortic Elastic Properties and Wave Reflection. J Hypertens. 2003;21(3):563-70. PubMed PMID: 12640250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of caffeine on aortic elastic properties and wave reflection. AU - Vlachopoulos,Charalambos, AU - Hirata,Kozo, AU - O'Rourke,Michael F, PY - 2003/3/18/pubmed PY - 2003/12/25/medline PY - 2003/3/18/entrez SP - 563 EP - 70 JF - Journal of hypertension JO - J. Hypertens. VL - 21 IS - 3 N2 - OBJECTIVE: Caffeine is the most widely used pharmacologically active substance. Aortic elastic properties and arterial wave reflection are important factors for the efficient performance of the cardiovascular system, as well as prognosticators of cardiovascular risk. We investigated the effect of caffeine on aortic elastic properties and wave reflection. DESIGN: We studied the effect of caffeine (250 mg) in 20 healthy subjects according to a randomized, placebo-controlled, double-blind, cross-over design. METHODS: Aortic stiffness was evaluated with carotid-femoral pulse wave velocity and wave reflection with augmentation index of the aortic pressure waveform. RESULTS: Pulse wave velocity increased (by 0.51 m/s, 0.001) denoting an increase in aortic stiffness. Augmentation index and augmented pressure increased (by 6.8%, and by 4.4 mmHg, respectively, P <0.001 for both) denoting increased wave reflections. Concurrently, both radial and aortic systolic, diastolic and pulse pressure increased significantly. However, this increase was 20 and 9% larger for aortic systolic pressure (at 30 and 60 min, P <0.001 and P <0.05, respectively) and 56% larger for aortic pulse pressure (at 30 min, P <0.001) compared with the corresponding upper limb values. This indicates that peripheral pressure measurements are not an accurate guide for the pressor effect of caffeine in central arteries. CONCLUSIONS: Caffeine affects unfavorably aortic stiffness and enhances wave reflections. This finding has implications for the impact of caffeine consumption on cardiovascular risk. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/12640250/Effect_of_caffeine_on_aortic_elastic_properties_and_wave_reflection_ L2 - http://dx.doi.org/10.1097/00004872-200303000-00022 DB - PRIME DP - Unbound Medicine ER -