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Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitation fraction under pharmacological influence. Echocardiographic study.
Arq Bras Cardiol. 2003 Feb; 80(2):144-9, 138-43.AB

Abstract

OBJECTIVE

To study echocardiographic parameters of left ventricular systolic function and valvar regurgitation under pharmacological influence in mildly symptomatic patients with chronic mitral regurgitation (MR).

METHODS

We carried out a double-blind placebo controlled study in 12 patients with MR, mean aged 12.5 years old, who were randomized in 4 phases: A) digoxin; B) enalapril; C) digoxin + enalapril; D) placebo. The medication was administered for 30 days in each phase, and the following variables were analyzed: shortening and ejection fractions, wall stress index of left ventricle, left ventricular meridional end-systolic wall stress, Doppler-derived mean rate of left ventricular pressure rise (mean dP/dt), stroke volume and MR jet area. The clinical variables analysed were heart rate and systemic arterial pressure.

RESULTS

No significant variation was observed in the clinical variables analysed. The shortening and ejection fraction, the mean dP/dt and stroke volume significantly increased and the wall stress index of left ventricle, the meridional left ventricular end systolic wall stress and the mitral regurgitation jet area decreased in the phases with medication as compared with that in the placebo phase.

CONCLUSION

The parameters of left ventricular systolic function improved significantly and the degree of MR decreased with the isolated administration of digoxin or enalapril in mildly symptomatic patients with chronic MR. The combination of the drugs, however, did not show better results.

Authors+Show Affiliations

Escola Paulista de Medicina, UNIFESP, São Paulo, SP, Brazil. irrivera@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12640508

Citation

Rivera, Ivan Romero, et al. "Mildly Symptomatic Chronic Mitral Regurgitation. Analysis of Left Ventricular Systolic Function and Mitral Regurgitation Fraction Under Pharmacological Influence. Echocardiographic Study." Arquivos Brasileiros De Cardiologia, vol. 80, no. 2, 2003, pp. 144-9, 138-43.
Rivera IR, Moisés VA, Carvalho AC, et al. Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitation fraction under pharmacological influence. Echocardiographic study. Arq Bras Cardiol. 2003;80(2):144-9, 138-43.
Rivera, I. R., Moisés, V. A., Carvalho, A. C., & de Paola, A. A. (2003). Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitation fraction under pharmacological influence. Echocardiographic study. Arquivos Brasileiros De Cardiologia, 80(2), 144-9, 138-43.
Rivera IR, et al. Mildly Symptomatic Chronic Mitral Regurgitation. Analysis of Left Ventricular Systolic Function and Mitral Regurgitation Fraction Under Pharmacological Influence. Echocardiographic Study. Arq Bras Cardiol. 2003;80(2):144-9, 138-43. PubMed PMID: 12640508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mildly symptomatic chronic mitral regurgitation. Analysis of left ventricular systolic function and mitral regurgitation fraction under pharmacological influence. Echocardiographic study. AU - Rivera,Ivan Romero, AU - Moisés,Valdir Ambrósio, AU - Carvalho,Antonio Carlos, AU - de Paola,Angelo Amato V, Y1 - 2003/02/25/ PY - 2003/3/18/pubmed PY - 2003/6/5/medline PY - 2003/3/18/entrez SP - 144-9, 138-43 JF - Arquivos brasileiros de cardiologia JO - Arq Bras Cardiol VL - 80 IS - 2 N2 - OBJECTIVE: To study echocardiographic parameters of left ventricular systolic function and valvar regurgitation under pharmacological influence in mildly symptomatic patients with chronic mitral regurgitation (MR). METHODS: We carried out a double-blind placebo controlled study in 12 patients with MR, mean aged 12.5 years old, who were randomized in 4 phases: A) digoxin; B) enalapril; C) digoxin + enalapril; D) placebo. The medication was administered for 30 days in each phase, and the following variables were analyzed: shortening and ejection fractions, wall stress index of left ventricle, left ventricular meridional end-systolic wall stress, Doppler-derived mean rate of left ventricular pressure rise (mean dP/dt), stroke volume and MR jet area. The clinical variables analysed were heart rate and systemic arterial pressure. RESULTS: No significant variation was observed in the clinical variables analysed. The shortening and ejection fraction, the mean dP/dt and stroke volume significantly increased and the wall stress index of left ventricle, the meridional left ventricular end systolic wall stress and the mitral regurgitation jet area decreased in the phases with medication as compared with that in the placebo phase. CONCLUSION: The parameters of left ventricular systolic function improved significantly and the degree of MR decreased with the isolated administration of digoxin or enalapril in mildly symptomatic patients with chronic MR. The combination of the drugs, however, did not show better results. SN - 0066-782X UR - https://www.unboundmedicine.com/medline/citation/12640508/Mildly_symptomatic_chronic_mitral_regurgitation__Analysis_of_left_ventricular_systolic_function_and_mitral_regurgitation_fraction_under_pharmacological_influence__Echocardiographic_study_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000200003&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -