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[Tissue anti-transglutaminase antibodies: a better test to detect minor dietary transgressions in celiac patients?].
Rev Med Chil. 2003 Jan; 131(1):25-9.RM

Abstract

BACKGROUND

Endomysium antibodies (EMA) do not detect minor dietary transgressions in patients with celiac disease.

AIM

To compare the sensitivity and specificity of tissue transglutaminase antibodies (tTGA) and endomysium antibodies (EMA) in biopsy proven celiac patients at the time of diagnosis and during gluten free diet (GFD).

PATIENTS AND METHODS

One hundred fifty three subjects were studied: a) 30 healthy controls; b) 9 cases with cow's milk allergy; c) 24 celiac patients at time of diagnosis; d) 25 celiac patients adhering to the GFD; e) 65 celiac patients with poor/no adhesion to GFD. EMA and tTGA IgA were measured by immunofluorescence and ELISA, respectively.

RESULTS

Sensitivity and specificity were 100% and 97.4% for tTGA, respectively. All patients with cow's milk allergy were EMA (-) and 8 of 9 (88.9%) were tTGA (-). In celiac patients not adhering to the GFD, EMA and tTGA positivity were similar (80% and 81.5%, respectively); 95.4% of the subjects tested positive for at least one of them. All patients adhering to GFD were EMA (-) but tTGA were (+) in 28% of them.

CONCLUSIONS

EMA and tTGA have similar sensitivity and specificity at the time of diagnosis of celiac disease. Positive tTGA in 28% of patients that adhered strictly to the GFD and whose EMA were negative suggest that tTGA may be helpful in detecting minor dietary transgressions and should be further evaluated.

Authors+Show Affiliations

Area de Nutrición Humana y Clínica, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, Chile. mgottela@uec.inta.uchile.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

12643215

Citation

Gotteland, Martin, et al. "[Tissue Anti-transglutaminase Antibodies: a Better Test to Detect Minor Dietary Transgressions in Celiac Patients?]." Revista Medica De Chile, vol. 131, no. 1, 2003, pp. 25-9.
Gotteland M, Verbeke S, Cruchet S, et al. [Tissue anti-transglutaminase antibodies: a better test to detect minor dietary transgressions in celiac patients?]. Rev Med Chil. 2003;131(1):25-9.
Gotteland, M., Verbeke, S., Cruchet, S., Brunser, O., Ríos, G., Hunter, B., & Araya, M. (2003). [Tissue anti-transglutaminase antibodies: a better test to detect minor dietary transgressions in celiac patients?]. Revista Medica De Chile, 131(1), 25-9.
Gotteland M, et al. [Tissue Anti-transglutaminase Antibodies: a Better Test to Detect Minor Dietary Transgressions in Celiac Patients?]. Rev Med Chil. 2003;131(1):25-9. PubMed PMID: 12643215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Tissue anti-transglutaminase antibodies: a better test to detect minor dietary transgressions in celiac patients?]. AU - Gotteland,Martin, AU - Verbeke,Sandra, AU - Cruchet,Sylvia, AU - Brunser,Oscar, AU - Ríos,Gloria, AU - Hunter,Bessy, AU - Araya,Magdalena, PY - 2003/3/20/pubmed PY - 2003/6/5/medline PY - 2003/3/20/entrez SP - 25 EP - 9 JF - Revista medica de Chile JO - Rev Med Chil VL - 131 IS - 1 N2 - BACKGROUND: Endomysium antibodies (EMA) do not detect minor dietary transgressions in patients with celiac disease. AIM: To compare the sensitivity and specificity of tissue transglutaminase antibodies (tTGA) and endomysium antibodies (EMA) in biopsy proven celiac patients at the time of diagnosis and during gluten free diet (GFD). PATIENTS AND METHODS: One hundred fifty three subjects were studied: a) 30 healthy controls; b) 9 cases with cow's milk allergy; c) 24 celiac patients at time of diagnosis; d) 25 celiac patients adhering to the GFD; e) 65 celiac patients with poor/no adhesion to GFD. EMA and tTGA IgA were measured by immunofluorescence and ELISA, respectively. RESULTS: Sensitivity and specificity were 100% and 97.4% for tTGA, respectively. All patients with cow's milk allergy were EMA (-) and 8 of 9 (88.9%) were tTGA (-). In celiac patients not adhering to the GFD, EMA and tTGA positivity were similar (80% and 81.5%, respectively); 95.4% of the subjects tested positive for at least one of them. All patients adhering to GFD were EMA (-) but tTGA were (+) in 28% of them. CONCLUSIONS: EMA and tTGA have similar sensitivity and specificity at the time of diagnosis of celiac disease. Positive tTGA in 28% of patients that adhered strictly to the GFD and whose EMA were negative suggest that tTGA may be helpful in detecting minor dietary transgressions and should be further evaluated. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/12643215/[Tissue_anti_transglutaminase_antibodies:_a_better_test_to_detect_minor_dietary_transgressions_in_celiac_patients]_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -