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Dehydration in stressed ruminants may be the result of a cortisol-induced diuresis.
J Anim Sci. 2003 Feb; 81(2):512-9.JA

Abstract

The effect on water and electrolyte balance of stress, simulated by intravenous infusion of cortisol, was studied using 24 18-mo-old Merino wethers (37.0 +/- 0.94 kg mean body weight [BW]) over 72 h. The sheep were allocated to one of four groups: 1) no water/no cortisol (n = 6); 2) water/no cortisol (n = 4); 3) no water/cortisol (n = 6); and 4) water/cortisol (n = 4). Animals allocated to the two cortisol groups were given 0.1 mg x kg BW(-1) x h(-1) of hydrocortisone suspended in isotonic saline to simulate stress for the duration of the experiment. Total body water, plasma cortisol, osmolality and electrolytes, and urine electrolytes were determined at 24-h intervals for 72 h. In the presence of cortisol, total body water was maintained in the face of a water deprivation insult for 72 h. Water deprivation alone did not induce elevated plasma concentrations of cortisol, in spite of a 13% loss of total body water between 48 and 72 h. Infusion of cortisol was found to increase urine output (P = 0.003) and decrease total urinary sodium output (P = 0.032), but had no effect on plasma electrolyte levels or water intake. Water deprivation was found to increase plasma sodium concentrations (P = 0.037). These results indicate that sheep given cortisol to simulate stress suffer from a loss of body water in excess of that associated with a loss of electrolytes, and support the hypothesis that elevated physiological concentrations of cortisol induce a diuresis in ruminants that contributes to dehydration.

Authors+Show Affiliations

Australian Institute of Tropical Veterinary and Animal Science, School of Biomedical Sciences, James Cook University, Townsville 4811, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12643496

Citation

Parker, A J., et al. "Dehydration in Stressed Ruminants May Be the Result of a Cortisol-induced Diuresis." Journal of Animal Science, vol. 81, no. 2, 2003, pp. 512-9.
Parker AJ, Hamlin GP, Coleman CJ, et al. Dehydration in stressed ruminants may be the result of a cortisol-induced diuresis. J Anim Sci. 2003;81(2):512-9.
Parker, A. J., Hamlin, G. P., Coleman, C. J., & Fitzpatrick, L. A. (2003). Dehydration in stressed ruminants may be the result of a cortisol-induced diuresis. Journal of Animal Science, 81(2), 512-9.
Parker AJ, et al. Dehydration in Stressed Ruminants May Be the Result of a Cortisol-induced Diuresis. J Anim Sci. 2003;81(2):512-9. PubMed PMID: 12643496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dehydration in stressed ruminants may be the result of a cortisol-induced diuresis. AU - Parker,A J, AU - Hamlin,G P, AU - Coleman,C J, AU - Fitzpatrick,L A, PY - 2003/3/20/pubmed PY - 2003/6/21/medline PY - 2003/3/20/entrez SP - 512 EP - 9 JF - Journal of animal science JO - J. Anim. Sci. VL - 81 IS - 2 N2 - The effect on water and electrolyte balance of stress, simulated by intravenous infusion of cortisol, was studied using 24 18-mo-old Merino wethers (37.0 +/- 0.94 kg mean body weight [BW]) over 72 h. The sheep were allocated to one of four groups: 1) no water/no cortisol (n = 6); 2) water/no cortisol (n = 4); 3) no water/cortisol (n = 6); and 4) water/cortisol (n = 4). Animals allocated to the two cortisol groups were given 0.1 mg x kg BW(-1) x h(-1) of hydrocortisone suspended in isotonic saline to simulate stress for the duration of the experiment. Total body water, plasma cortisol, osmolality and electrolytes, and urine electrolytes were determined at 24-h intervals for 72 h. In the presence of cortisol, total body water was maintained in the face of a water deprivation insult for 72 h. Water deprivation alone did not induce elevated plasma concentrations of cortisol, in spite of a 13% loss of total body water between 48 and 72 h. Infusion of cortisol was found to increase urine output (P = 0.003) and decrease total urinary sodium output (P = 0.032), but had no effect on plasma electrolyte levels or water intake. Water deprivation was found to increase plasma sodium concentrations (P = 0.037). These results indicate that sheep given cortisol to simulate stress suffer from a loss of body water in excess of that associated with a loss of electrolytes, and support the hypothesis that elevated physiological concentrations of cortisol induce a diuresis in ruminants that contributes to dehydration. SN - 0021-8812 UR - https://www.unboundmedicine.com/medline/citation/12643496/Dehydration_in_stressed_ruminants_may_be_the_result_of_a_cortisol_induced_diuresis_ L2 - https://academic.oup.com/jas/article-lookup/doi/10.2527/2003.812512x DB - PRIME DP - Unbound Medicine ER -