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Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory.
Synapse. 2003 Jun 01; 48(3):138-48.S

Abstract

In previous studies, we have shown that P11-20 treatment with D-methamphetamine (MA) (10 mg/kg x 4/day at 2-h intervals) induces impairments in spatial learning and memory in the Morris water maze after the offspring reach adulthood. Using a split-litter, multiple dose, design (0, 5, 10, and 15 mg/kg MA administered s.c. 4/day at 2-h intervals), the spatial learning effect was further explored with a multiple shifted platform (reversal), reference memory-based procedure and a working memory procedure. Prior to spatial learning, animals were first tested for swimming ability (in a straight swimming channel), sequential learning (in the Cincinnati multiple-T water maze), and proximal cue learning (in the Morris water maze). Rats were then assessed in the hidden platform, reference memory-based spatial version of the Morris maze for acquisition and on five subsequent phases in which the platform was moved to new locations. After the reference memory-based, fixed platform position learning phases, animals were tested in the trial-dependent, matching-to-sample, working memory version of the Morris maze. No group differences were found in straight channel, sequential maze, or cued Morris maze performance. By contrast, all MA groups were impaired in spatial learning during acquisition, multiple shift, and shifted with a reduced platform phases of reference memory-based learning. In addition, MA animals were impaired on memory (probe) trials during the acquisition and shifted with a reduced platform phases of learning. No effects on trial-dependent, matching-to-sample, working memory were found. The findings demonstrate that neonatal treatment with MA induces a selective impairment of reference memory-based spatial learning while sparing sequential, cued, and working memory-based learning.

Authors+Show Affiliations

Pharmacology Research Center, Children's Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12645039

Citation

Williams, Michael T., et al. "Developmental D-methamphetamine Treatment Selectively Induces Spatial Navigation Impairments in Reference Memory in the Morris Water Maze While Sparing Working Memory." Synapse (New York, N.Y.), vol. 48, no. 3, 2003, pp. 138-48.
Williams MT, Morford LL, Wood SL, et al. Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory. Synapse. 2003;48(3):138-48.
Williams, M. T., Morford, L. L., Wood, S. L., Wallace, T. L., Fukumura, M., Broening, H. W., & Vorhees, C. V. (2003). Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory. Synapse (New York, N.Y.), 48(3), 138-48.
Williams MT, et al. Developmental D-methamphetamine Treatment Selectively Induces Spatial Navigation Impairments in Reference Memory in the Morris Water Maze While Sparing Working Memory. Synapse. 2003 Jun 1;48(3):138-48. PubMed PMID: 12645039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental D-methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory. AU - Williams,Michael T, AU - Morford,LaRonda L, AU - Wood,Sandra L, AU - Wallace,Tanya L, AU - Fukumura,Masao, AU - Broening,Harry W, AU - Vorhees,Charles V, PY - 2003/3/20/pubmed PY - 2003/5/31/medline PY - 2003/3/20/entrez SP - 138 EP - 48 JF - Synapse (New York, N.Y.) JO - Synapse VL - 48 IS - 3 N2 - In previous studies, we have shown that P11-20 treatment with D-methamphetamine (MA) (10 mg/kg x 4/day at 2-h intervals) induces impairments in spatial learning and memory in the Morris water maze after the offspring reach adulthood. Using a split-litter, multiple dose, design (0, 5, 10, and 15 mg/kg MA administered s.c. 4/day at 2-h intervals), the spatial learning effect was further explored with a multiple shifted platform (reversal), reference memory-based procedure and a working memory procedure. Prior to spatial learning, animals were first tested for swimming ability (in a straight swimming channel), sequential learning (in the Cincinnati multiple-T water maze), and proximal cue learning (in the Morris water maze). Rats were then assessed in the hidden platform, reference memory-based spatial version of the Morris maze for acquisition and on five subsequent phases in which the platform was moved to new locations. After the reference memory-based, fixed platform position learning phases, animals were tested in the trial-dependent, matching-to-sample, working memory version of the Morris maze. No group differences were found in straight channel, sequential maze, or cued Morris maze performance. By contrast, all MA groups were impaired in spatial learning during acquisition, multiple shift, and shifted with a reduced platform phases of reference memory-based learning. In addition, MA animals were impaired on memory (probe) trials during the acquisition and shifted with a reduced platform phases of learning. No effects on trial-dependent, matching-to-sample, working memory were found. The findings demonstrate that neonatal treatment with MA induces a selective impairment of reference memory-based spatial learning while sparing sequential, cued, and working memory-based learning. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/12645039/Developmental_D_methamphetamine_treatment_selectively_induces_spatial_navigation_impairments_in_reference_memory_in_the_Morris_water_maze_while_sparing_working_memory_ L2 - https://doi.org/10.1002/syn.10159 DB - PRIME DP - Unbound Medicine ER -