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Australian tiger snake (Notechis scutatus) and mexican coral snake (Micruris species) antivenoms prevent death from United States coral snake (Micrurus fulvius fulvius) venom in a mouse model.
J Toxicol Clin Toxicol. 2003; 41(1):7-10.JT

Abstract

BACKGROUND

Wyeth-Ayerst has discontinued production of Antivenin (Micrurus fulvius). Currently, there is no other approved coral snake antivenom available in the United States.

METHODS

This study was a randomized, placebo-controlled and blinded determination of the ability of a Mexican Micrurus (coral snake) antivenom and an Australian Notechis (tiger snake) antivenom to prevent lethality from a United States Micrurus fulvius fulvius venom in a mouse model. Venom dosing was based on an LD50 determined for this experiment. Our comparison groups included: (1) M. f. fulvius venom + Micrurus antivenom, (2) M. f. fulvius venom + Notechis antivenom, (3) M. f. fulvius venom + protein control, (4) 0.9% normal saline + protein control, (5) saline + Notechis antivenom, (6) saline + Micrurus antivenom. Venom dose was 5 times the determined LD50. The antivenom amounts were capable of neutralizing 10 times the venom injected (50 times the LD50).

RESULTS

The LD50 of M. f. fulvius venom was determined to be 0.85 mg/kg. All mice in both antivenom test groups were protected from lethality for the entire 24-hour observation period. Six of the 7 mice in the venom test group died, with a survival time of 349 +/- 382 minutes (mean +/- s.d.) after the venom injection. All three groups of control mice survived the entire 24-hour observation period.

CONCLUSIONS

Mexican Micrurus antivenom and Australian Notechis antivenom provide protection from lethality in mice envenomated with a United States M. f. filvius venom.

Authors+Show Affiliations

Rocky Mountain Poison and Drug Center, Denver Health Authority, Denver, Colorado 80230-6800, USANo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12645961

Citation

Wisniewski, Michael S., et al. "Australian Tiger Snake (Notechis Scutatus) and Mexican Coral Snake (Micruris Species) Antivenoms Prevent Death From United States Coral Snake (Micrurus Fulvius Fulvius) Venom in a Mouse Model." Journal of Toxicology. Clinical Toxicology, vol. 41, no. 1, 2003, pp. 7-10.
Wisniewski MS, Hill RE, Havey JM, et al. Australian tiger snake (Notechis scutatus) and mexican coral snake (Micruris species) antivenoms prevent death from United States coral snake (Micrurus fulvius fulvius) venom in a mouse model. J Toxicol Clin Toxicol. 2003;41(1):7-10.
Wisniewski, M. S., Hill, R. E., Havey, J. M., Bogdan, G. M., & Dart, R. C. (2003). Australian tiger snake (Notechis scutatus) and mexican coral snake (Micruris species) antivenoms prevent death from United States coral snake (Micrurus fulvius fulvius) venom in a mouse model. Journal of Toxicology. Clinical Toxicology, 41(1), 7-10.
Wisniewski MS, et al. Australian Tiger Snake (Notechis Scutatus) and Mexican Coral Snake (Micruris Species) Antivenoms Prevent Death From United States Coral Snake (Micrurus Fulvius Fulvius) Venom in a Mouse Model. J Toxicol Clin Toxicol. 2003;41(1):7-10. PubMed PMID: 12645961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Australian tiger snake (Notechis scutatus) and mexican coral snake (Micruris species) antivenoms prevent death from United States coral snake (Micrurus fulvius fulvius) venom in a mouse model. AU - Wisniewski,Michael S, AU - Hill,Robert E, AU - Havey,Joshua M, AU - Bogdan,Gregory M, AU - Dart,Richard C, PY - 2003/3/21/pubmed PY - 2003/4/2/medline PY - 2003/3/21/entrez SP - 7 EP - 10 JF - Journal of toxicology. Clinical toxicology JO - J. Toxicol. Clin. Toxicol. VL - 41 IS - 1 N2 - BACKGROUND: Wyeth-Ayerst has discontinued production of Antivenin (Micrurus fulvius). Currently, there is no other approved coral snake antivenom available in the United States. METHODS: This study was a randomized, placebo-controlled and blinded determination of the ability of a Mexican Micrurus (coral snake) antivenom and an Australian Notechis (tiger snake) antivenom to prevent lethality from a United States Micrurus fulvius fulvius venom in a mouse model. Venom dosing was based on an LD50 determined for this experiment. Our comparison groups included: (1) M. f. fulvius venom + Micrurus antivenom, (2) M. f. fulvius venom + Notechis antivenom, (3) M. f. fulvius venom + protein control, (4) 0.9% normal saline + protein control, (5) saline + Notechis antivenom, (6) saline + Micrurus antivenom. Venom dose was 5 times the determined LD50. The antivenom amounts were capable of neutralizing 10 times the venom injected (50 times the LD50). RESULTS: The LD50 of M. f. fulvius venom was determined to be 0.85 mg/kg. All mice in both antivenom test groups were protected from lethality for the entire 24-hour observation period. Six of the 7 mice in the venom test group died, with a survival time of 349 +/- 382 minutes (mean +/- s.d.) after the venom injection. All three groups of control mice survived the entire 24-hour observation period. CONCLUSIONS: Mexican Micrurus antivenom and Australian Notechis antivenom provide protection from lethality in mice envenomated with a United States M. f. filvius venom. SN - 0731-3810 UR - https://www.unboundmedicine.com/medline/citation/12645961/Australian_tiger_snake__Notechis_scutatus__and_mexican_coral_snake__Micruris_species__antivenoms_prevent_death_from_United_States_coral_snake__Micrurus_fulvius_fulvius__venom_in_a_mouse_model_ DB - PRIME DP - Unbound Medicine ER -