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Comparison of oral pentobarbital sodium (nembutal) and oral chloral hydrate for sedation of infants during radiologic imaging: preliminary results.
AJR Am J Roentgenol 2003; 180(4):1125-8AA

Abstract

OBJECTIVE

The purpose of this study was to compare the safety and efficacy of oral cherry-flavored pentobarbital sodium (Nembutal) and oral chloral hydrate to sedate infants undergoing radiologic imaging.

SUBJECTS AND METHODS

We prospectively recorded data for all infants sedated with oral cherry-flavored pentobarbital sodium and oral chloral hydrate for imaging examinations between January 1997 and August 1999. The parameters recorded were each patient's age, weight, and American Society of Anesthesiologists classification; the time required to sedate; the total length of sedation time; the time required to discharge from the recovery room; and adverse events. The two-sample Student's t test and Fisher's exact test were used for statistical analysis.

RESULTS

Oral pentobarbital sodium was administered to 317 infants. These infants had a mean age +/- SD of 6.9 +/- 3.1 months and a mean weight of 7.8 +/- 4.8 kg; they received a median dose of 4 mg/kg of body weight. Oral chloral hydrate was administered to 358 infants. These infants had a mean age of 5.9 +/- 3.3 months and a mean weight of 7.3 +/- 4.9 kg; they received a median dose of 50 mg/kg of body weight. The mean time required to sedate was 19 +/- 14 min for infants receiving oral pentobarbital sodium and 16 +/- 11 min for infants receiving oral chloral hydrate (p = 0.02); the mean time required to discharge was 100 +/- 35 min for infants in the oral pentobarbital sodium group and 103 +/- 36 min for infants in the oral chloral hydrate group (p = 0.31); the mean length of sedation was 81 +/- 34 min for the oral pentobarbital sodium group and 86 +/- 36 min for the oral chloral hydrate group (p = 0.07); and median American Society of Anesthesiologists classification for both groups was P1. Oral pentobarbital sodium was inadequate for sedation in one patient (0.3%) and chloral hydrate was inadequate for sedation in another (0.3%) (p = 1.00). Adverse events were recorded for five patients (1.6%) in the oral pentobarbital sodium group and for six patients (1.7%) in the chloral hydrate group (p = 0.99).

CONCLUSION

Oral pentobarbital sodium is as safe and efficacious as oral chloral hydrate for sedating infants.

Authors+Show Affiliations

Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA 02115,USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Evaluation Studies
Journal Article

Language

eng

PubMed ID

12646468

Citation

Rooks, Veronica J., et al. "Comparison of Oral Pentobarbital Sodium (nembutal) and Oral Chloral Hydrate for Sedation of Infants During Radiologic Imaging: Preliminary Results." AJR. American Journal of Roentgenology, vol. 180, no. 4, 2003, pp. 1125-8.
Rooks VJ, Chung T, Connor L, et al. Comparison of oral pentobarbital sodium (nembutal) and oral chloral hydrate for sedation of infants during radiologic imaging: preliminary results. AJR Am J Roentgenol. 2003;180(4):1125-8.
Rooks, V. J., Chung, T., Connor, L., Zurakowski, D., Hoffer, F. A., Mason, K. P., & Burrows, P. E. (2003). Comparison of oral pentobarbital sodium (nembutal) and oral chloral hydrate for sedation of infants during radiologic imaging: preliminary results. AJR. American Journal of Roentgenology, 180(4), pp. 1125-8.
Rooks VJ, et al. Comparison of Oral Pentobarbital Sodium (nembutal) and Oral Chloral Hydrate for Sedation of Infants During Radiologic Imaging: Preliminary Results. AJR Am J Roentgenol. 2003;180(4):1125-8. PubMed PMID: 12646468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of oral pentobarbital sodium (nembutal) and oral chloral hydrate for sedation of infants during radiologic imaging: preliminary results. AU - Rooks,Veronica J, AU - Chung,Taylor, AU - Connor,Linda, AU - Zurakowski,David, AU - Hoffer,Frederic A, AU - Mason,Keira P, AU - Burrows,Patricia E, PY - 2003/3/21/pubmed PY - 2003/5/6/medline PY - 2003/3/21/entrez SP - 1125 EP - 8 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 180 IS - 4 N2 - OBJECTIVE: The purpose of this study was to compare the safety and efficacy of oral cherry-flavored pentobarbital sodium (Nembutal) and oral chloral hydrate to sedate infants undergoing radiologic imaging. SUBJECTS AND METHODS: We prospectively recorded data for all infants sedated with oral cherry-flavored pentobarbital sodium and oral chloral hydrate for imaging examinations between January 1997 and August 1999. The parameters recorded were each patient's age, weight, and American Society of Anesthesiologists classification; the time required to sedate; the total length of sedation time; the time required to discharge from the recovery room; and adverse events. The two-sample Student's t test and Fisher's exact test were used for statistical analysis. RESULTS: Oral pentobarbital sodium was administered to 317 infants. These infants had a mean age +/- SD of 6.9 +/- 3.1 months and a mean weight of 7.8 +/- 4.8 kg; they received a median dose of 4 mg/kg of body weight. Oral chloral hydrate was administered to 358 infants. These infants had a mean age of 5.9 +/- 3.3 months and a mean weight of 7.3 +/- 4.9 kg; they received a median dose of 50 mg/kg of body weight. The mean time required to sedate was 19 +/- 14 min for infants receiving oral pentobarbital sodium and 16 +/- 11 min for infants receiving oral chloral hydrate (p = 0.02); the mean time required to discharge was 100 +/- 35 min for infants in the oral pentobarbital sodium group and 103 +/- 36 min for infants in the oral chloral hydrate group (p = 0.31); the mean length of sedation was 81 +/- 34 min for the oral pentobarbital sodium group and 86 +/- 36 min for the oral chloral hydrate group (p = 0.07); and median American Society of Anesthesiologists classification for both groups was P1. Oral pentobarbital sodium was inadequate for sedation in one patient (0.3%) and chloral hydrate was inadequate for sedation in another (0.3%) (p = 1.00). Adverse events were recorded for five patients (1.6%) in the oral pentobarbital sodium group and for six patients (1.7%) in the chloral hydrate group (p = 0.99). CONCLUSION: Oral pentobarbital sodium is as safe and efficacious as oral chloral hydrate for sedating infants. SN - 0361-803X UR - https://www.unboundmedicine.com/medline/citation/12646468/Comparison_of_oral_pentobarbital_sodium__nembutal__and_oral_chloral_hydrate_for_sedation_of_infants_during_radiologic_imaging:_preliminary_results_ L2 - http://www.ajronline.org/doi/full/10.2214/ajr.180.4.1801125 DB - PRIME DP - Unbound Medicine ER -