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Handedness and risk of brain tumors in adults.

Abstract

The objective of this study was to evaluate the relation between handedness, and the risk of malignant and benign brain tumors. Handedness has been hypothesized to serve as a behavioral marker of prenatal hormonal exposures or other factors that influence subsequent cancer risk. A case-control study was conducted at hospitals in three United States cities between 1994 and 1998. The cases were adult patients newly diagnosed with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96), and the 799 frequency-matched controls were patients admitted to the same hospitals for a variety of nonmalignant conditions. Handedness was determined by interview. Unconditional logistic regression was used to estimate odds ratios (ORs) and calculate 95% confidence intervals (CIs). Persons who described themselves as left-handed or ambidextrous appeared to be at reduced risk of glioma relative to those who described themselves as right-handed (OR, 0.7; 95% CI, 0.5-0.9). The association was similar for men and women, and for left-sided and right-sided tumors. Neither meningioma (OR, 0.9; CI, 0.6-1.5) nor acoustic neuroma (OR, 0.9; CI, 0.5-1.7) showed significant associations with handedness. These findings require confirmation but raise the possibility that early neurodevelopmental events or genetic factors related to handedness also influence the risk of glioma among adults.

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  • Authors+Show Affiliations

    ,

    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.

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    Source

    MeSH

    Adult
    Aged
    Brain Neoplasms
    Case-Control Studies
    Confidence Intervals
    Female
    Functional Laterality
    Glioma
    Humans
    Logistic Models
    Male
    Meningeal Neoplasms
    Meningioma
    Middle Aged
    Neuroma, Acoustic
    Odds Ratio
    Pregnancy
    Prenatal Exposure Delayed Effects
    Risk
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    12646512

    Citation

    Inskip, Peter D., et al. "Handedness and Risk of Brain Tumors in Adults." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 3, 2003, pp. 223-5.
    Inskip PD, Tarone RE, Brenner AV, et al. Handedness and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev. 2003;12(3):223-5.
    Inskip, P. D., Tarone, R. E., Brenner, A. V., Fine, H. A., Black, P. M., Shapiro, W. R., ... Linet, M. S. (2003). Handedness and risk of brain tumors in adults. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(3), pp. 223-5.
    Inskip PD, et al. Handedness and Risk of Brain Tumors in Adults. Cancer Epidemiol Biomarkers Prev. 2003;12(3):223-5. PubMed PMID: 12646512.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Handedness and risk of brain tumors in adults. AU - Inskip,Peter D, AU - Tarone,Robert E, AU - Brenner,Alina V, AU - Fine,Howard A, AU - Black,Peter M, AU - Shapiro,William R, AU - Selker,Robert G, AU - Linet,Martha S, PY - 2003/3/21/pubmed PY - 2003/12/3/medline PY - 2003/3/21/entrez SP - 223 EP - 5 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 3 N2 - The objective of this study was to evaluate the relation between handedness, and the risk of malignant and benign brain tumors. Handedness has been hypothesized to serve as a behavioral marker of prenatal hormonal exposures or other factors that influence subsequent cancer risk. A case-control study was conducted at hospitals in three United States cities between 1994 and 1998. The cases were adult patients newly diagnosed with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96), and the 799 frequency-matched controls were patients admitted to the same hospitals for a variety of nonmalignant conditions. Handedness was determined by interview. Unconditional logistic regression was used to estimate odds ratios (ORs) and calculate 95% confidence intervals (CIs). Persons who described themselves as left-handed or ambidextrous appeared to be at reduced risk of glioma relative to those who described themselves as right-handed (OR, 0.7; 95% CI, 0.5-0.9). The association was similar for men and women, and for left-sided and right-sided tumors. Neither meningioma (OR, 0.9; CI, 0.6-1.5) nor acoustic neuroma (OR, 0.9; CI, 0.5-1.7) showed significant associations with handedness. These findings require confirmation but raise the possibility that early neurodevelopmental events or genetic factors related to handedness also influence the risk of glioma among adults. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/12646512/Handedness_and_risk_of_brain_tumors_in_adults_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=12646512 DB - PRIME DP - Unbound Medicine ER -