Tags

Type your tag names separated by a space and hit enter

Carbamazepine/betaCD/HPMC solid dispersions. I. Influence of the spray-drying process and betaCD/HPMC on the drug dissolution profile.
Drug Dev Ind Pharm. 2003 Feb; 29(2):139-44.DD

Abstract

The aim of this study was to compare carbamazepine (CBZ) solid dispersions prepared by spray-drying of aqueous dispersions with the corresponding physical mixtures. The influence of the association of beta-cyclodextrin (betaCD) and hydroxypropyl methylcellulose (HPMC) on the CBZ dissolution profile of the preparations was investigated. Results demonstrated that CBZ release from solid dispersions is dependent on the ratio of betaCD and HPMC. The spray-drying process confers better homogeneity to CBZ polymeric dispersions than the physical mixture process. In summary, we demonstrated the feasibility of obtaining a homogeneous polymeric solid dispersion of CBZ from an aqueous media by spray-drying and a clear influence of the betaCD:HPMC ratio on the release profile of CBZ.

Authors+Show Affiliations

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12648010

Citation

Koester, Letícia S., et al. "Carbamazepine/betaCD/HPMC Solid Dispersions. I. Influence of the Spray-drying Process and betaCD/HPMC On the Drug Dissolution Profile." Drug Development and Industrial Pharmacy, vol. 29, no. 2, 2003, pp. 139-44.
Koester LS, Mayorga P, Bassani VL. Carbamazepine/betaCD/HPMC solid dispersions. I. Influence of the spray-drying process and betaCD/HPMC on the drug dissolution profile. Drug Dev Ind Pharm. 2003;29(2):139-44.
Koester, L. S., Mayorga, P., & Bassani, V. L. (2003). Carbamazepine/betaCD/HPMC solid dispersions. I. Influence of the spray-drying process and betaCD/HPMC on the drug dissolution profile. Drug Development and Industrial Pharmacy, 29(2), 139-44.
Koester LS, Mayorga P, Bassani VL. Carbamazepine/betaCD/HPMC Solid Dispersions. I. Influence of the Spray-drying Process and betaCD/HPMC On the Drug Dissolution Profile. Drug Dev Ind Pharm. 2003;29(2):139-44. PubMed PMID: 12648010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbamazepine/betaCD/HPMC solid dispersions. I. Influence of the spray-drying process and betaCD/HPMC on the drug dissolution profile. AU - Koester,Letícia S, AU - Mayorga,Paulo, AU - Bassani,Valquiria L, PY - 2003/3/22/pubmed PY - 2003/10/22/medline PY - 2003/3/22/entrez SP - 139 EP - 44 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 29 IS - 2 N2 - The aim of this study was to compare carbamazepine (CBZ) solid dispersions prepared by spray-drying of aqueous dispersions with the corresponding physical mixtures. The influence of the association of beta-cyclodextrin (betaCD) and hydroxypropyl methylcellulose (HPMC) on the CBZ dissolution profile of the preparations was investigated. Results demonstrated that CBZ release from solid dispersions is dependent on the ratio of betaCD and HPMC. The spray-drying process confers better homogeneity to CBZ polymeric dispersions than the physical mixture process. In summary, we demonstrated the feasibility of obtaining a homogeneous polymeric solid dispersion of CBZ from an aqueous media by spray-drying and a clear influence of the betaCD:HPMC ratio on the release profile of CBZ. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/12648010/Carbamazepine/betaCD/HPMC_solid_dispersions__I__Influence_of_the_spray_drying_process_and_betaCD/HPMC_on_the_drug_dissolution_profile_ L2 - http://www.tandfonline.com/doi/full/10.1081/ddc-120016721 DB - PRIME DP - Unbound Medicine ER -