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Carbamazepine/betaCD/HPMC solid dispersions. II. Physical characterization.
Drug Dev Ind Pharm. 2003 Feb; 29(2):145-54.DD

Abstract

Solid dispersions containing carbamazepine (CBZ) associated with beta-cyclodextrin (betaCD) and/or hydroxypropyl methylcellulose were prepared by two different methods, spray-drying or physical mixture, and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), infrared (IR) spectroscopy, and x-ray powder diffraction analysis (XRPD) studies. Scanning electron microscopy pictures showed that spray-drying produced a mixture of hollow, spherical, and partially shrunken microparticles of homogeneous materials, whereas the physical mixtures yielded heterogeneous systems in which all individual components could be identified. Thermal and IR analyses suggest the existence of a strong interaction between CBZ and excipients in spray-dried solid dispersions, but no CBZ polymorphic transition was detected by either IR spectroscopy or XRPD analysis after the spray-drying process.

Authors+Show Affiliations

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12648011

Citation

Koester, L S., et al. "Carbamazepine/betaCD/HPMC Solid Dispersions. II. Physical Characterization." Drug Development and Industrial Pharmacy, vol. 29, no. 2, 2003, pp. 145-54.
Koester LS, Mayorga P, Pereira VP, et al. Carbamazepine/betaCD/HPMC solid dispersions. II. Physical characterization. Drug Dev Ind Pharm. 2003;29(2):145-54.
Koester, L. S., Mayorga, P., Pereira, V. P., Petzhold, C. L., & Bassani, V. L. (2003). Carbamazepine/betaCD/HPMC solid dispersions. II. Physical characterization. Drug Development and Industrial Pharmacy, 29(2), 145-54.
Koester LS, et al. Carbamazepine/betaCD/HPMC Solid Dispersions. II. Physical Characterization. Drug Dev Ind Pharm. 2003;29(2):145-54. PubMed PMID: 12648011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbamazepine/betaCD/HPMC solid dispersions. II. Physical characterization. AU - Koester,L S, AU - Mayorga,P, AU - Pereira,V P, AU - Petzhold,C L, AU - Bassani,V L, PY - 2003/3/22/pubmed PY - 2003/10/22/medline PY - 2003/3/22/entrez SP - 145 EP - 54 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 29 IS - 2 N2 - Solid dispersions containing carbamazepine (CBZ) associated with beta-cyclodextrin (betaCD) and/or hydroxypropyl methylcellulose were prepared by two different methods, spray-drying or physical mixture, and characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), infrared (IR) spectroscopy, and x-ray powder diffraction analysis (XRPD) studies. Scanning electron microscopy pictures showed that spray-drying produced a mixture of hollow, spherical, and partially shrunken microparticles of homogeneous materials, whereas the physical mixtures yielded heterogeneous systems in which all individual components could be identified. Thermal and IR analyses suggest the existence of a strong interaction between CBZ and excipients in spray-dried solid dispersions, but no CBZ polymorphic transition was detected by either IR spectroscopy or XRPD analysis after the spray-drying process. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/12648011/Carbamazepine/betaCD/HPMC_solid_dispersions__II__Physical_characterization_ L2 - http://www.tandfonline.com/doi/full/10.1081/ddc-120016722 DB - PRIME DP - Unbound Medicine ER -