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Influence of hydroxypropyl beta-cyclodextrin on the corneal permeation of pilocarpine.
Drug Dev Ind Pharm 2003; 29(2):223-30DD

Abstract

The influence of hydroxypropyl beta-cyclodextrin (HPbetaCD) on the corneal permeation of pilocarpine nitrate was investigated by an in vitro permeability study using isolated rabbit cornea. Pupillary-response pattern to pilocarpine nitrate with and without HPbetaCD was examined in rabbit eye. Corneal permeation of pilocarpine nitrate was found to be four times higher after adding HPbetaCD into the formulation. The reduction of pupil diameter (miosis) by pilocarpine nitrate was significantly increased as a result of HPbetaCD addition into the simple aqueous solution of the active substance. The highest miotic response was obtained with the formulation prepared in a vehicle of Carbopol 940. It is suggested that ocular bioavailability of pilocarpine nitrate could be improved by the addition of HPbetaCD.

Authors+Show Affiliations

Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12648019

Citation

Aktaş, Yeşim, et al. "Influence of Hydroxypropyl Beta-cyclodextrin On the Corneal Permeation of Pilocarpine." Drug Development and Industrial Pharmacy, vol. 29, no. 2, 2003, pp. 223-30.
Aktaş Y, Unlü N, Orhan M, et al. Influence of hydroxypropyl beta-cyclodextrin on the corneal permeation of pilocarpine. Drug Dev Ind Pharm. 2003;29(2):223-30.
Aktaş, Y., Unlü, N., Orhan, M., Irkeç, M., & Hincal, A. A. (2003). Influence of hydroxypropyl beta-cyclodextrin on the corneal permeation of pilocarpine. Drug Development and Industrial Pharmacy, 29(2), pp. 223-30.
Aktaş Y, et al. Influence of Hydroxypropyl Beta-cyclodextrin On the Corneal Permeation of Pilocarpine. Drug Dev Ind Pharm. 2003;29(2):223-30. PubMed PMID: 12648019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hydroxypropyl beta-cyclodextrin on the corneal permeation of pilocarpine. AU - Aktaş,Yeşim, AU - Unlü,Nurşen, AU - Orhan,Mehmet, AU - Irkeç,Murat, AU - Hincal,A Atilla, PY - 2003/3/22/pubmed PY - 2003/10/22/medline PY - 2003/3/22/entrez SP - 223 EP - 30 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 29 IS - 2 N2 - The influence of hydroxypropyl beta-cyclodextrin (HPbetaCD) on the corneal permeation of pilocarpine nitrate was investigated by an in vitro permeability study using isolated rabbit cornea. Pupillary-response pattern to pilocarpine nitrate with and without HPbetaCD was examined in rabbit eye. Corneal permeation of pilocarpine nitrate was found to be four times higher after adding HPbetaCD into the formulation. The reduction of pupil diameter (miosis) by pilocarpine nitrate was significantly increased as a result of HPbetaCD addition into the simple aqueous solution of the active substance. The highest miotic response was obtained with the formulation prepared in a vehicle of Carbopol 940. It is suggested that ocular bioavailability of pilocarpine nitrate could be improved by the addition of HPbetaCD. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/12648019/Influence_of_hydroxypropyl_beta_cyclodextrin_on_the_corneal_permeation_of_pilocarpine_ L2 - http://www.tandfonline.com/doi/full/10.1081/ddc-120016730 DB - PRIME DP - Unbound Medicine ER -