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Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion.
Acta Obstet Gynecol Scand. 2003 Feb; 82(2):182-8.AO

Abstract

OBJECTIVE

To study the association between cigarette, alcohol, and caffeine consumption and the occurrence of spontaneous abortion.

METHODS

The study population consisted of 330 women with spontaneous abortion and 1168 pregnant women receiving antenatal care. A case-control design was utilized; cases were defined as women with a spontaneous abortion in gestational week 6-16 and controls as women with a live fetus in gestational week 6-16. The variables studied comprise age, parity, occupational situation, cigarette, alcohol, and caffeine consumption. The association between cigarette, alcohol, and caffeine consumption was studied using logistic regression analyzes while controlling for confounding variables. In addition stratified analyzes of the association between caffeine consumption and spontaneous abortion on the basis of cigarette and alcohol consumption were performed.

RESULTS

Women who had given birth twice or more previously had increased odds ratio (OR), 1.78 (1.27-2.49), whereas women who were students had decreased OR, 0.55 (0.34-0.91) for having spontaneous abortions. Regarding lifestyle factors, the adjusted ORs among women who consumed 5 units or more alcohol per week or 375 mg or more caffeine per day were 4.84 (2.87-8.16) and 2.21 (1.53-3.18), respectively. Women who smoked 10-19 cigarettes and 20 or more cigarettes per day did not have significantly increased ORs for having spontaneous abortions, after adjusting for other risk factors.

CONCLUSION

Consumption of 5 or more units alcohol per week and 375 mg or more caffeine per day during pregnancy may increase the risk of spontaneous abortion.

Authors+Show Affiliations

Institute of Public Health, Department of Epidemiology, University of Southern Denmark, Denmark. v.rasch@dadlnet.dk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12648183

Citation

Rasch, Vibeke. "Cigarette, Alcohol, and Caffeine Consumption: Risk Factors for Spontaneous Abortion." Acta Obstetricia Et Gynecologica Scandinavica, vol. 82, no. 2, 2003, pp. 182-8.
Rasch V. Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion. Acta Obstet Gynecol Scand. 2003;82(2):182-8.
Rasch, V. (2003). Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion. Acta Obstetricia Et Gynecologica Scandinavica, 82(2), 182-8.
Rasch V. Cigarette, Alcohol, and Caffeine Consumption: Risk Factors for Spontaneous Abortion. Acta Obstet Gynecol Scand. 2003;82(2):182-8. PubMed PMID: 12648183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette, alcohol, and caffeine consumption: risk factors for spontaneous abortion. A1 - Rasch,Vibeke, PY - 2003/3/22/pubmed PY - 2003/4/19/medline PY - 2003/3/22/entrez SP - 182 EP - 8 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 82 IS - 2 N2 - OBJECTIVE: To study the association between cigarette, alcohol, and caffeine consumption and the occurrence of spontaneous abortion. METHODS: The study population consisted of 330 women with spontaneous abortion and 1168 pregnant women receiving antenatal care. A case-control design was utilized; cases were defined as women with a spontaneous abortion in gestational week 6-16 and controls as women with a live fetus in gestational week 6-16. The variables studied comprise age, parity, occupational situation, cigarette, alcohol, and caffeine consumption. The association between cigarette, alcohol, and caffeine consumption was studied using logistic regression analyzes while controlling for confounding variables. In addition stratified analyzes of the association between caffeine consumption and spontaneous abortion on the basis of cigarette and alcohol consumption were performed. RESULTS: Women who had given birth twice or more previously had increased odds ratio (OR), 1.78 (1.27-2.49), whereas women who were students had decreased OR, 0.55 (0.34-0.91) for having spontaneous abortions. Regarding lifestyle factors, the adjusted ORs among women who consumed 5 units or more alcohol per week or 375 mg or more caffeine per day were 4.84 (2.87-8.16) and 2.21 (1.53-3.18), respectively. Women who smoked 10-19 cigarettes and 20 or more cigarettes per day did not have significantly increased ORs for having spontaneous abortions, after adjusting for other risk factors. CONCLUSION: Consumption of 5 or more units alcohol per week and 375 mg or more caffeine per day during pregnancy may increase the risk of spontaneous abortion. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/12648183/Cigarette_alcohol_and_caffeine_consumption:_risk_factors_for_spontaneous_abortion_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6349&date=2003&volume=82&issue=2&spage=182 DB - PRIME DP - Unbound Medicine ER -