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Phytoestrogens and breast cancer.
J Steroid Biochem Mol Biol 2002; 83(1-5):113-8JS

Abstract

The role of phytoestrogens and consumption of phytoestrogen-rich foods such as soy containing isoflavones and whole grain products with lignans for the prevention of breast cancer is reviewed. It is concluded that soy-containing diet in adult women is not or only slightly protective with regard to breast cancer, but that it may be beneficial if consumed in early life before puberty or during adolescence supporting results of immigrant and epidemiological studies. No negative effects of soy on breast cancer have been observed. On the other hand, a diet low in lignans, resulting in a low plasma enterolactone concentration, increases risk both in a case-control and a prospective study, but some controversial results have also been obtained. Some of these results may be explained by the fact that the determinants of plasma or urinary enterolactone concentration are very different in different countries. In Scandinavia, the main determinants are whole grain cereal food, vegetables and berries. Whether the protective effect is caused by the phytoestrogens in the diet or whether they are only biomarkers of a healthy diet has not been established.

Authors+Show Affiliations

Institute for Preventive Medicine, Nutrition, and Cancer, Folkhälsan Research Center, and Division of Clinical Chemistry, University of Helsinki, PL 60, Helsinki FIN-00014, Finland. herman.adlercreutz@helsinki.fi

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12650707

Citation

Adlercreutz, Herman. "Phytoestrogens and Breast Cancer." The Journal of Steroid Biochemistry and Molecular Biology, vol. 83, no. 1-5, 2002, pp. 113-8.
Adlercreutz H. Phytoestrogens and breast cancer. J Steroid Biochem Mol Biol. 2002;83(1-5):113-8.
Adlercreutz, H. (2002). Phytoestrogens and breast cancer. The Journal of Steroid Biochemistry and Molecular Biology, 83(1-5), pp. 113-8.
Adlercreutz H. Phytoestrogens and Breast Cancer. J Steroid Biochem Mol Biol. 2002;83(1-5):113-8. PubMed PMID: 12650707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytoestrogens and breast cancer. A1 - Adlercreutz,Herman, PY - 2003/3/26/pubmed PY - 2003/5/24/medline PY - 2003/3/26/entrez SP - 113 EP - 8 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 83 IS - 1-5 N2 - The role of phytoestrogens and consumption of phytoestrogen-rich foods such as soy containing isoflavones and whole grain products with lignans for the prevention of breast cancer is reviewed. It is concluded that soy-containing diet in adult women is not or only slightly protective with regard to breast cancer, but that it may be beneficial if consumed in early life before puberty or during adolescence supporting results of immigrant and epidemiological studies. No negative effects of soy on breast cancer have been observed. On the other hand, a diet low in lignans, resulting in a low plasma enterolactone concentration, increases risk both in a case-control and a prospective study, but some controversial results have also been obtained. Some of these results may be explained by the fact that the determinants of plasma or urinary enterolactone concentration are very different in different countries. In Scandinavia, the main determinants are whole grain cereal food, vegetables and berries. Whether the protective effect is caused by the phytoestrogens in the diet or whether they are only biomarkers of a healthy diet has not been established. SN - 0960-0760 UR - https://www.unboundmedicine.com/medline/citation/12650707/Phytoestrogens_and_breast_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S096007600200273X DB - PRIME DP - Unbound Medicine ER -