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Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.
Cardiovasc Drugs Ther. 2002 Sep; 16(5):443-9.CD

Abstract

We examined the effects of long-term monotherapy with the beta-blocker, metoprolol controlled release/extended release (CR/XL), on the progression of LV dysfunction as well as on global and cellular remodeling in dogs with heart failure (HF). Chronic HF was produced by intracoronary microembolizations that were discontinued when LV ejection fraction (EF) was between 30% and 40%. Dogs were randomized to 3 months oral monotherapy with metoprolol CR/XL (100 mg once daily, n = 7) or no therapy at all (control, n = 7). In control dogs, EF decreased from 38 +/- 1% to 31 +/- 2% (p = 0.002), and LV end-systolic volume (ESV) and LV end-diastolic volume (EDV) increased (37 +/- 2 vs 45 +/- 2 ml, p = 0.001; 59 +/- 3 vs 65 +/- 3 ml, p = 0.001; respectively) during the 3 month follow-up period. In dogs treated with metoprolol CR/XL, EF increased after 3 months from 36 +/- 1% to 43 +/- 1% (p = 0.001), and ESV decreased (42 +/- 2 vs 38 +/- 2 ml, p = 0.003), whereas EDV remained unchanged. Compared to controls, treatment with metoprolol CR/XL showed 46% reduction in replacement fibrosis, 54% reduction in interstitial fibrosis and 20% reduction in myocyte cross-sectional area, a measure of myocyte hypertrophy. These findings indicate that metoprolol CR/XL improves LV function and attenuates progressive global and cellular LV remodeling in dogs with HF. The benefits are fully attributable to beta-blockade alone as no other adjunctive therapy was used.

Authors+Show Affiliations

Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, MI, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12652114

Citation

Morita, Hideaki, et al. "Effects of Long-term Monotherapy With Metoprolol CR/XL On the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure." Cardiovascular Drugs and Therapy, vol. 16, no. 5, 2002, pp. 443-9.
Morita H, Suzuki G, Mishima T, et al. Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Cardiovasc Drugs Ther. 2002;16(5):443-9.
Morita, H., Suzuki, G., Mishima, T., Chaudhry, P. A., Anagnostopoulos, P. V., Tanhehco, E. J., Sharov, V. G., Goldstein, S., & Sabbah, H. N. (2002). Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Cardiovascular Drugs and Therapy, 16(5), 443-9.
Morita H, et al. Effects of Long-term Monotherapy With Metoprolol CR/XL On the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure. Cardiovasc Drugs Ther. 2002;16(5):443-9. PubMed PMID: 12652114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. AU - Morita,Hideaki, AU - Suzuki,George, AU - Mishima,Takayuki, AU - Chaudhry,Pervaiz A, AU - Anagnostopoulos,Petros V, AU - Tanhehco,Elaine J, AU - Sharov,Victor G, AU - Goldstein,Sidney, AU - Sabbah,Hani N, PY - 2003/3/26/pubmed PY - 2003/5/21/medline PY - 2003/3/26/entrez SP - 443 EP - 9 JF - Cardiovascular drugs and therapy JO - Cardiovasc Drugs Ther VL - 16 IS - 5 N2 - We examined the effects of long-term monotherapy with the beta-blocker, metoprolol controlled release/extended release (CR/XL), on the progression of LV dysfunction as well as on global and cellular remodeling in dogs with heart failure (HF). Chronic HF was produced by intracoronary microembolizations that were discontinued when LV ejection fraction (EF) was between 30% and 40%. Dogs were randomized to 3 months oral monotherapy with metoprolol CR/XL (100 mg once daily, n = 7) or no therapy at all (control, n = 7). In control dogs, EF decreased from 38 +/- 1% to 31 +/- 2% (p = 0.002), and LV end-systolic volume (ESV) and LV end-diastolic volume (EDV) increased (37 +/- 2 vs 45 +/- 2 ml, p = 0.001; 59 +/- 3 vs 65 +/- 3 ml, p = 0.001; respectively) during the 3 month follow-up period. In dogs treated with metoprolol CR/XL, EF increased after 3 months from 36 +/- 1% to 43 +/- 1% (p = 0.001), and ESV decreased (42 +/- 2 vs 38 +/- 2 ml, p = 0.003), whereas EDV remained unchanged. Compared to controls, treatment with metoprolol CR/XL showed 46% reduction in replacement fibrosis, 54% reduction in interstitial fibrosis and 20% reduction in myocyte cross-sectional area, a measure of myocyte hypertrophy. These findings indicate that metoprolol CR/XL improves LV function and attenuates progressive global and cellular LV remodeling in dogs with HF. The benefits are fully attributable to beta-blockade alone as no other adjunctive therapy was used. SN - 0920-3206 UR - https://www.unboundmedicine.com/medline/citation/12652114/Effects_of_long_term_monotherapy_with_metoprolol_CR/XL_on_the_progression_of_left_ventricular_dysfunction_and_remodeling_in_dogs_with_chronic_heart_failure_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12652114.ui DB - PRIME DP - Unbound Medicine ER -