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Inflammation and infection in exacerbations of chronic obstructive pulmonary disease.
Semin Respir Infect. 2003 Mar; 18(1):9-16.SR

Abstract

Chronic obstructive pulmonary disease (COPD) is a common disorder with symptoms of chronic cough and progressive dyspnea caused by chronic bronchitis or emphysema. Acute exacerbations of COPD contribute to the accelerated decline in lung function characteristic of this disease and are associated with significant cost, morbidity, and mortality for patients. Controversy exists as to whether exacerbations are caused primarily by inflammation, infection, or perhaps a combination of both conditions. Advances in the pathogenesis of COPD have shed light on the role of inflammation in this condition and highlighted the differences in the inflammatory response present in COPD compared with asthma. Infectious agents often are suspected as causing acute exacerbations of COPD, and antibiotics are frequently prescribed empirically to patients. We review the evidence for an inflammatory and infectious etiology for exacerbations of COPD and compare and contrast how each impacts on this disease.

Authors+Show Affiliations

Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12652449

Citation

Pietila, Michael P., and Charles F. Thomas. "Inflammation and Infection in Exacerbations of Chronic Obstructive Pulmonary Disease." Seminars in Respiratory Infections, vol. 18, no. 1, 2003, pp. 9-16.
Pietila MP, Thomas CF. Inflammation and infection in exacerbations of chronic obstructive pulmonary disease. Semin Respir Infect. 2003;18(1):9-16.
Pietila, M. P., & Thomas, C. F. (2003). Inflammation and infection in exacerbations of chronic obstructive pulmonary disease. Seminars in Respiratory Infections, 18(1), 9-16.
Pietila MP, Thomas CF. Inflammation and Infection in Exacerbations of Chronic Obstructive Pulmonary Disease. Semin Respir Infect. 2003;18(1):9-16. PubMed PMID: 12652449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammation and infection in exacerbations of chronic obstructive pulmonary disease. AU - Pietila,Michael P, AU - Thomas,Charles F, PY - 2003/3/26/pubmed PY - 2003/5/8/medline PY - 2003/3/26/entrez SP - 9 EP - 16 JF - Seminars in respiratory infections JO - Semin Respir Infect VL - 18 IS - 1 N2 - Chronic obstructive pulmonary disease (COPD) is a common disorder with symptoms of chronic cough and progressive dyspnea caused by chronic bronchitis or emphysema. Acute exacerbations of COPD contribute to the accelerated decline in lung function characteristic of this disease and are associated with significant cost, morbidity, and mortality for patients. Controversy exists as to whether exacerbations are caused primarily by inflammation, infection, or perhaps a combination of both conditions. Advances in the pathogenesis of COPD have shed light on the role of inflammation in this condition and highlighted the differences in the inflammatory response present in COPD compared with asthma. Infectious agents often are suspected as causing acute exacerbations of COPD, and antibiotics are frequently prescribed empirically to patients. We review the evidence for an inflammatory and infectious etiology for exacerbations of COPD and compare and contrast how each impacts on this disease. SN - 0882-0546 UR - https://www.unboundmedicine.com/medline/citation/12652449/Inflammation_and_infection_in_exacerbations_of_chronic_obstructive_pulmonary_disease_ L2 - http://www.diseaseinfosearch.org/result/7979 DB - PRIME DP - Unbound Medicine ER -
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