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Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women.
Br J Nutr. 2003 Apr; 89(4):467-74.BJ

Abstract

Consumption of isoflavone-rich soyabean protein is reported to reduce total and LDL-cholesterol, but the specific components responsible are undetermined. In a previous crossover trial we showed that purified isoflavones, derived from red clover (Trifolium pratense), raised HDL3-cholesterol in premenopausal women; however, these findings were inconclusive due to period and carryover effects. In an attempt to overcome this problem, we utilised a parallel study designed to re-examine the effects of purified isoflavones on plasma lipoproteins and markers of insulin resistance in premenopausal women. Twenty-five healthy premenopausal women participated in a double-blind, randomised, parallel study. The treatment group (n 12) consumed a placebo for the first menstrual cycle and an isoflavone supplement (86 mg/d, derived from red clover) for three cycles, while the placebo group (n 13) consumed a placebo supplement for four menstrual cycles. Blood samples were collected weekly during cycles 1, 3 and 4. Supplementation with isoflavones resulted in a 15-fold increase in urinary isoflavone excretion (P<0.0001). There were no significant effects on total cholesterol, LDL- and HDL-cholesterol, HDL subfractions, triacylglycerol, lipoprotein(a), glucose or insulin concentrations. Our present results indicate that purified isoflavones derived from red clover have no effect on cholesterol homeostasis or insulin resistance in premenopausal women, a group which is at low risk of CHD.

Authors+Show Affiliations

Human Nutrition Unit, School of Molecular and Microbial Biosciences, University of Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12654164

Citation

Blakesmith, Sarah J., et al. "Effects of Supplementation With Purified Red Clover (Trifolium Pratense) Isoflavones On Plasma Lipids and Insulin Resistance in Healthy Premenopausal Women." The British Journal of Nutrition, vol. 89, no. 4, 2003, pp. 467-74.
Blakesmith SJ, Lyons-Wall PM, George C, et al. Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women. Br J Nutr. 2003;89(4):467-74.
Blakesmith, S. J., Lyons-Wall, P. M., George, C., Joannou, G. E., Petocz, P., & Samman, S. (2003). Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women. The British Journal of Nutrition, 89(4), 467-74.
Blakesmith SJ, et al. Effects of Supplementation With Purified Red Clover (Trifolium Pratense) Isoflavones On Plasma Lipids and Insulin Resistance in Healthy Premenopausal Women. Br J Nutr. 2003;89(4):467-74. PubMed PMID: 12654164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplementation with purified red clover (Trifolium pratense) isoflavones on plasma lipids and insulin resistance in healthy premenopausal women. AU - Blakesmith,Sarah J, AU - Lyons-Wall,Philippa M, AU - George,Caroline, AU - Joannou,George E, AU - Petocz,Peter, AU - Samman,Samir, PY - 2003/3/26/pubmed PY - 2003/5/22/medline PY - 2003/3/26/entrez SP - 467 EP - 74 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 89 IS - 4 N2 - Consumption of isoflavone-rich soyabean protein is reported to reduce total and LDL-cholesterol, but the specific components responsible are undetermined. In a previous crossover trial we showed that purified isoflavones, derived from red clover (Trifolium pratense), raised HDL3-cholesterol in premenopausal women; however, these findings were inconclusive due to period and carryover effects. In an attempt to overcome this problem, we utilised a parallel study designed to re-examine the effects of purified isoflavones on plasma lipoproteins and markers of insulin resistance in premenopausal women. Twenty-five healthy premenopausal women participated in a double-blind, randomised, parallel study. The treatment group (n 12) consumed a placebo for the first menstrual cycle and an isoflavone supplement (86 mg/d, derived from red clover) for three cycles, while the placebo group (n 13) consumed a placebo supplement for four menstrual cycles. Blood samples were collected weekly during cycles 1, 3 and 4. Supplementation with isoflavones resulted in a 15-fold increase in urinary isoflavone excretion (P<0.0001). There were no significant effects on total cholesterol, LDL- and HDL-cholesterol, HDL subfractions, triacylglycerol, lipoprotein(a), glucose or insulin concentrations. Our present results indicate that purified isoflavones derived from red clover have no effect on cholesterol homeostasis or insulin resistance in premenopausal women, a group which is at low risk of CHD. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12654164/Effects_of_supplementation_with_purified_red_clover__Trifolium_pratense__isoflavones_on_plasma_lipids_and_insulin_resistance_in_healthy_premenopausal_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=12654164.ui DB - PRIME DP - Unbound Medicine ER -