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The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study.
Br J Nutr. 2003 Apr; 89(4):517-22.BJ

Abstract

C-reactive protein (CRP) is a sensitive marker for low-grade inflammation. Long-chain n-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects. The objective of the present study was to investigate the effect on serum levels of CRP of n-3 PUFA at two different doses. We also investigated correlations between CRP and the cellular contents of PUFA. Sixty healthy volunteers (twenty-five women and thirty-five men) were randomly assigned to three treatment groups in a double-blind design. The subjects received a supplement of either 6.6 g n-3 PUFA/d, 2.0 g n-3 PUFA/d or placebo (olive oil) for 12 weeks. CRP was measured using a highly sensitive assay. The median serum CRP concentration was 0.78 mg/l. No significant correlations were found between CRP and the content of n-3 PUFA in granulocytes or platelets. Subjects receiving n-3 PUFA had a significant (P<0.01) increase in the cellular contents of 20 : 5n-3, 22 : 5n-3 and 22 : 6n-3, with the largest increase occurring in the group receiving 6.6 g PUFA/d. A significant (P<0.01) decrease in cellular content of 18 : 2n-6 and 20 : 4n-6 was observed simultaneously. Serum CRP concentrations, however, were unaffected by the PUFA-containing supplements. The present study shows that dietary supplementation with PUFA-containing supplements has no effect on serum concentrations of CRP, measured with a highly sensitive assay, in healthy subjects.

Authors+Show Affiliations

Department of Cardiology, Aalborg Hospital, Denmark. tmadsen@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12654170

Citation

Madsen, Trine, et al. "The Effect of Dietary N-3 Fatty Acids On Serum Concentrations of C-reactive Protein: a Dose-response Study." The British Journal of Nutrition, vol. 89, no. 4, 2003, pp. 517-22.
Madsen T, Christensen JH, Blom M, et al. The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study. Br J Nutr. 2003;89(4):517-22.
Madsen, T., Christensen, J. H., Blom, M., & Schmidt, E. B. (2003). The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study. The British Journal of Nutrition, 89(4), 517-22.
Madsen T, et al. The Effect of Dietary N-3 Fatty Acids On Serum Concentrations of C-reactive Protein: a Dose-response Study. Br J Nutr. 2003;89(4):517-22. PubMed PMID: 12654170.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of dietary n-3 fatty acids on serum concentrations of C-reactive protein: a dose-response study. AU - Madsen,Trine, AU - Christensen,Jeppe H, AU - Blom,Mogens, AU - Schmidt,Erik B, PY - 2003/3/26/pubmed PY - 2003/5/22/medline PY - 2003/3/26/entrez SP - 517 EP - 22 JF - The British journal of nutrition JO - Br J Nutr VL - 89 IS - 4 N2 - C-reactive protein (CRP) is a sensitive marker for low-grade inflammation. Long-chain n-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects. The objective of the present study was to investigate the effect on serum levels of CRP of n-3 PUFA at two different doses. We also investigated correlations between CRP and the cellular contents of PUFA. Sixty healthy volunteers (twenty-five women and thirty-five men) were randomly assigned to three treatment groups in a double-blind design. The subjects received a supplement of either 6.6 g n-3 PUFA/d, 2.0 g n-3 PUFA/d or placebo (olive oil) for 12 weeks. CRP was measured using a highly sensitive assay. The median serum CRP concentration was 0.78 mg/l. No significant correlations were found between CRP and the content of n-3 PUFA in granulocytes or platelets. Subjects receiving n-3 PUFA had a significant (P<0.01) increase in the cellular contents of 20 : 5n-3, 22 : 5n-3 and 22 : 6n-3, with the largest increase occurring in the group receiving 6.6 g PUFA/d. A significant (P<0.01) decrease in cellular content of 18 : 2n-6 and 20 : 4n-6 was observed simultaneously. Serum CRP concentrations, however, were unaffected by the PUFA-containing supplements. The present study shows that dietary supplementation with PUFA-containing supplements has no effect on serum concentrations of CRP, measured with a highly sensitive assay, in healthy subjects. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12654170/The_effect_of_dietary_n_3_fatty_acids_on_serum_concentrations_of_C_reactive_protein:_a_dose_response_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=12654170.ui DB - PRIME DP - Unbound Medicine ER -