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A primary care cross-sectional study of undiagnosed adult coeliac disease.
Eur J Gastroenterol Hepatol 2003; 15(4):407-13EJ

Abstract

OBJECTIVES

To establish the prevalence of coeliac disease in the general population and in specific conditions, such as irritable bowel syndrome, iron deficiency anaemia, fatigue and other coeliac-related conditions.

METHODS

Primary-care-based cross-sectional study using immunoglobulins, IgA/IgG antigliadin antibodies and endomysial antibodies to initially recognize coeliac disease. A total of 1200 volunteers were recruited from January 1999 to June 2001 from five general practices in South Yorkshire, UK. Any participant with a positive IgA antigliadin antibody, positive endomysial antibody, or only IgG antigliadin antibody in the presence of IgA deficiency was offered a small-bowel biopsy to confirm the diagnosis of coeliac disease.

RESULTS

Twelve new cases of coeliac disease were diagnosed from 1200 samples. The prevalence of coeliac disease in this primary care population sample is 1% (95% CI 0.4-1.3%). The prevalence of coeliac disease was 3.3% (4/123) in participants with irritable bowel syndrome, 4.7% (3/64) in participants with iron deficiency anaemia, and 3.3% (3/92) in participants with fatigue.

CONCLUSIONS

This study describes the prevalence of undiagnosed adult coeliac disease in primary care patients with irritable bowel syndrome, iron deficiency anaemia and fatigue. Underdiagnosis of coeliac disease is common in primary care. A case-finding approach would avoid delays in diagnosis and the associated morbidity or potential complications of coeliac disease. A low threshold for serological screening of patients with coeliac-associated symptoms or conditions would be an optimal strategy.

Authors+Show Affiliations

Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK. d.s.sanders28@btopenworld.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12655262

Citation

Sanders, David S., et al. "A Primary Care Cross-sectional Study of Undiagnosed Adult Coeliac Disease." European Journal of Gastroenterology & Hepatology, vol. 15, no. 4, 2003, pp. 407-13.
Sanders DS, Patel D, Stephenson TJ, et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol. 2003;15(4):407-13.
Sanders, D. S., Patel, D., Stephenson, T. J., Ward, A. M., McCloskey, E. V., Hadjivassiliou, M., & Lobo, A. J. (2003). A primary care cross-sectional study of undiagnosed adult coeliac disease. European Journal of Gastroenterology & Hepatology, 15(4), pp. 407-13.
Sanders DS, et al. A Primary Care Cross-sectional Study of Undiagnosed Adult Coeliac Disease. Eur J Gastroenterol Hepatol. 2003;15(4):407-13. PubMed PMID: 12655262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A primary care cross-sectional study of undiagnosed adult coeliac disease. AU - Sanders,David S, AU - Patel,Dina, AU - Stephenson,Timothy J, AU - Ward,Anthony Milford, AU - McCloskey,Eugene V, AU - Hadjivassiliou,Marios, AU - Lobo,Alan J, PY - 2003/3/26/pubmed PY - 2003/5/30/medline PY - 2003/3/26/entrez SP - 407 EP - 13 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 15 IS - 4 N2 - OBJECTIVES: To establish the prevalence of coeliac disease in the general population and in specific conditions, such as irritable bowel syndrome, iron deficiency anaemia, fatigue and other coeliac-related conditions. METHODS: Primary-care-based cross-sectional study using immunoglobulins, IgA/IgG antigliadin antibodies and endomysial antibodies to initially recognize coeliac disease. A total of 1200 volunteers were recruited from January 1999 to June 2001 from five general practices in South Yorkshire, UK. Any participant with a positive IgA antigliadin antibody, positive endomysial antibody, or only IgG antigliadin antibody in the presence of IgA deficiency was offered a small-bowel biopsy to confirm the diagnosis of coeliac disease. RESULTS: Twelve new cases of coeliac disease were diagnosed from 1200 samples. The prevalence of coeliac disease in this primary care population sample is 1% (95% CI 0.4-1.3%). The prevalence of coeliac disease was 3.3% (4/123) in participants with irritable bowel syndrome, 4.7% (3/64) in participants with iron deficiency anaemia, and 3.3% (3/92) in participants with fatigue. CONCLUSIONS: This study describes the prevalence of undiagnosed adult coeliac disease in primary care patients with irritable bowel syndrome, iron deficiency anaemia and fatigue. Underdiagnosis of coeliac disease is common in primary care. A case-finding approach would avoid delays in diagnosis and the associated morbidity or potential complications of coeliac disease. A low threshold for serological screening of patients with coeliac-associated symptoms or conditions would be an optimal strategy. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/12655262/A_primary_care_cross_sectional_study_of_undiagnosed_adult_coeliac_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=12655262 DB - PRIME DP - Unbound Medicine ER -