Tags

Type your tag names separated by a space and hit enter

Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats.
Alcohol Clin Exp Res. 2003 Mar; 27(3):440-9.AC

Abstract

BACKGROUND

The formation of salsolinol (SAL) has been hypothesized to be a factor contributing to alcoholism and alcohol abuse. If SAL is formed under chronic alcohol-drinking conditions, then it may contribute to alcohol addiction by being rewarding itself. Because SAL can be formed by the nonenzymatic condensation of acetaldehyde with dopamine, the reinforcing effects of SAL were tested in the nucleus accumbens shell, a dopamine-rich site considered to be involved in regulating alcohol-drinking behavior.

METHODS

The intracranial self-administration technique was used to test the reinforcing properties of SAL. Adult, female alcohol-preferring (P) rats were stereotaxically implanted with guide cannulae aimed at the nucleus accumbens shell. After 7 to 10 days to allow recovery from surgery, P rats were attached to the electrolytic microinfusion transducer system, placed in two-lever experimental chambers, and allowed to respond for the self-infusion of 100 nl of modified artificial cerebrospinal fluid (aCSF) or 0.03, 0.3, 3.0, or 12.5 microM SAL (3-1250 fmol/100 nl). Sessions were 4 hr in duration and were conducted in the dark cycle every 48 hr. The effects of coinfusing 10 to 400 microM sulpiride (given in sessions 5 and 6 after four acquisition sessions) on the intracranial self-administration of 3.0 microM SAL were tested in a separate experiment.

RESULTS

P rats given 0.3 to 12.5 microM SAL received significantly more infusions per session than did the group given aCSF alone (e.g., 50 infusions for 3.0 microM SAL versus 10 or fewer infusions for the aCSF group) and responded significantly more on the active than inactive lever. Coinfusion of 100 or 400 microM sulpiride reduced the responding on the active lever (80-100 responses/session without sulpiride) to levels observed for the inactive lever (fewer than 10 responses/session with sulpiride). This effect was reversible because giving SAL alone in session 7 reinstated responding on the active lever.

CONCLUSIONS

SAL is reinforcing in the nucleus accumbens shell of P rats at concentrations that are pharmacologically possible, and these reinforcing actions are mediated in part by D2/D3-like receptors.

Authors+Show Affiliations

Indiana University School of Medicine, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202-4887, USA. zrodd@iupui.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12658109

Citation

Rodd, Zachary A., et al. "Salsolinol Produces Reinforcing Effects in the Nucleus Accumbens Shell of Alcohol-preferring (P) Rats." Alcoholism, Clinical and Experimental Research, vol. 27, no. 3, 2003, pp. 440-9.
Rodd ZA, Bell RL, Zhang Y, et al. Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2003;27(3):440-9.
Rodd, Z. A., Bell, R. L., Zhang, Y., Goldstein, A., Zaffaroni, A., McBride, W. J., & Li, T. K. (2003). Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats. Alcoholism, Clinical and Experimental Research, 27(3), 440-9.
Rodd ZA, et al. Salsolinol Produces Reinforcing Effects in the Nucleus Accumbens Shell of Alcohol-preferring (P) Rats. Alcohol Clin Exp Res. 2003;27(3):440-9. PubMed PMID: 12658109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats. AU - Rodd,Zachary A, AU - Bell,Richard L, AU - Zhang,Ying, AU - Goldstein,Avram, AU - Zaffaroni,Alejandro, AU - McBride,William J, AU - Li,Ting-Kai, PY - 2003/3/27/pubmed PY - 2003/9/25/medline PY - 2003/3/27/entrez SP - 440 EP - 9 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 27 IS - 3 N2 - BACKGROUND: The formation of salsolinol (SAL) has been hypothesized to be a factor contributing to alcoholism and alcohol abuse. If SAL is formed under chronic alcohol-drinking conditions, then it may contribute to alcohol addiction by being rewarding itself. Because SAL can be formed by the nonenzymatic condensation of acetaldehyde with dopamine, the reinforcing effects of SAL were tested in the nucleus accumbens shell, a dopamine-rich site considered to be involved in regulating alcohol-drinking behavior. METHODS: The intracranial self-administration technique was used to test the reinforcing properties of SAL. Adult, female alcohol-preferring (P) rats were stereotaxically implanted with guide cannulae aimed at the nucleus accumbens shell. After 7 to 10 days to allow recovery from surgery, P rats were attached to the electrolytic microinfusion transducer system, placed in two-lever experimental chambers, and allowed to respond for the self-infusion of 100 nl of modified artificial cerebrospinal fluid (aCSF) or 0.03, 0.3, 3.0, or 12.5 microM SAL (3-1250 fmol/100 nl). Sessions were 4 hr in duration and were conducted in the dark cycle every 48 hr. The effects of coinfusing 10 to 400 microM sulpiride (given in sessions 5 and 6 after four acquisition sessions) on the intracranial self-administration of 3.0 microM SAL were tested in a separate experiment. RESULTS: P rats given 0.3 to 12.5 microM SAL received significantly more infusions per session than did the group given aCSF alone (e.g., 50 infusions for 3.0 microM SAL versus 10 or fewer infusions for the aCSF group) and responded significantly more on the active than inactive lever. Coinfusion of 100 or 400 microM sulpiride reduced the responding on the active lever (80-100 responses/session without sulpiride) to levels observed for the inactive lever (fewer than 10 responses/session with sulpiride). This effect was reversible because giving SAL alone in session 7 reinstated responding on the active lever. CONCLUSIONS: SAL is reinforcing in the nucleus accumbens shell of P rats at concentrations that are pharmacologically possible, and these reinforcing actions are mediated in part by D2/D3-like receptors. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/12658109/Salsolinol_produces_reinforcing_effects_in_the_nucleus_accumbens_shell_of_alcohol_preferring__P__rats_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=12658109.ui DB - PRIME DP - Unbound Medicine ER -