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Coregulation of ethanol discrimination by the nucleus accumbens and amygdala.
Alcohol Clin Exp Res. 2003 Mar; 27(3):450-6.AC

Abstract

BACKGROUND

Activation of GABA(A) receptors in the amygdala or nucleus accumbens produces discriminative stimulus effects that substitute fully for those of systemically administered ethanol. This study was conducted to determine if GABA(A) receptors in the amygdala and nucleus accumbens interactively modulate ethanol discrimination.

METHODS

Male Long-Evans rats were trained to discriminate between intraperitoneal injections of ethanol (1 g/kg) and saline on a 2-lever drug discrimination task. The rats were then surgically implanted with bilateral injection cannulae aimed at the nucleus accumbens and the amygdala.

RESULTS

Infusion of the GABA(A) agonist muscimol in the nucleus accumbens resulted in full substitution for systemically administered ethanol. Concurrent infusion of the GABA(A) antagonist bicuculline in the amygdala shifted the muscimol substitution curve in the nucleus accumbens 10-fold to the right.

CONCLUSIONS

These results indicate that blockade of GABA(A) receptors in the amygdala significantly reduces the potency of the GABA(A) agonist in the nucleus accumbens. This suggests that the ethanol-like stimulus effects of GABA(A) receptor activation in the nucleus accumbens are modulated by GABA(A) receptor activity in the amygdala. These data support the hypothesis that the addictive stimulus properties of alcohol are mediated by GABAergic transmission in a neural circuit involving the amygdala and nucleus accumbens.

Authors+Show Affiliations

Bowles Center for Alcohol Studies, Thurston-Bowles Building; CB#7178, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12658110

Citation

Besheer, Joyce, et al. "Coregulation of Ethanol Discrimination By the Nucleus Accumbens and Amygdala." Alcoholism, Clinical and Experimental Research, vol. 27, no. 3, 2003, pp. 450-6.
Besheer J, Cox AA, Hodge CW. Coregulation of ethanol discrimination by the nucleus accumbens and amygdala. Alcohol Clin Exp Res. 2003;27(3):450-6.
Besheer, J., Cox, A. A., & Hodge, C. W. (2003). Coregulation of ethanol discrimination by the nucleus accumbens and amygdala. Alcoholism, Clinical and Experimental Research, 27(3), 450-6.
Besheer J, Cox AA, Hodge CW. Coregulation of Ethanol Discrimination By the Nucleus Accumbens and Amygdala. Alcohol Clin Exp Res. 2003;27(3):450-6. PubMed PMID: 12658110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coregulation of ethanol discrimination by the nucleus accumbens and amygdala. AU - Besheer,Joyce, AU - Cox,Amy A, AU - Hodge,Clyde W, PY - 2003/3/27/pubmed PY - 2003/9/25/medline PY - 2003/3/27/entrez SP - 450 EP - 6 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 27 IS - 3 N2 - BACKGROUND: Activation of GABA(A) receptors in the amygdala or nucleus accumbens produces discriminative stimulus effects that substitute fully for those of systemically administered ethanol. This study was conducted to determine if GABA(A) receptors in the amygdala and nucleus accumbens interactively modulate ethanol discrimination. METHODS: Male Long-Evans rats were trained to discriminate between intraperitoneal injections of ethanol (1 g/kg) and saline on a 2-lever drug discrimination task. The rats were then surgically implanted with bilateral injection cannulae aimed at the nucleus accumbens and the amygdala. RESULTS: Infusion of the GABA(A) agonist muscimol in the nucleus accumbens resulted in full substitution for systemically administered ethanol. Concurrent infusion of the GABA(A) antagonist bicuculline in the amygdala shifted the muscimol substitution curve in the nucleus accumbens 10-fold to the right. CONCLUSIONS: These results indicate that blockade of GABA(A) receptors in the amygdala significantly reduces the potency of the GABA(A) agonist in the nucleus accumbens. This suggests that the ethanol-like stimulus effects of GABA(A) receptor activation in the nucleus accumbens are modulated by GABA(A) receptor activity in the amygdala. These data support the hypothesis that the addictive stimulus properties of alcohol are mediated by GABAergic transmission in a neural circuit involving the amygdala and nucleus accumbens. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/12658110/Coregulation_of_ethanol_discrimination_by_the_nucleus_accumbens_and_amygdala_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2003&volume=27&issue=3&spage=450 DB - PRIME DP - Unbound Medicine ER -