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Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs.
Ultrasound Med Biol. 2003 Feb; 29(2):311-7.UM

Abstract

Recent studies have shown that ultrasound (US)-mediated transdermal drug delivery offers a promising potential for noninvasive drug administration. The purpose of this study was to improve low-frequency (20 kHz) US methods for enhancing the transport of insulin in vitro across human skin. The feasibility of using US produced by small, lightweight novel transducers was explored for enhancing the transport of insulin across skin. Previous investigators have used US devices such as large, heavy sonicators or commercially obtained transducers for this type of research. The experiments carried out in this study used two low-profile novel US transducer arrays, the stack and standard array, for improved transport of insulin. The stack array generated a spatial peak temporal peak intensity (I(SPTP)) of 15.4 +/- 0.6 mW/cm(2) and the standard array had an I(SPTP) of 173.7 +/- 1.2 mW/cm(2). Spectrophotometeric absorption techniques were used for determining insulin transport in vitro across human skin. Compared with passive transmission (4.1 +/- 0.5 U) over an exposure period of 1 h, the standard array facilitated over a sevenfold increase in the noninvasive transdermal transport of Humulin R insulin (45.9 +/- 12.9 U). Using Humalog insulin with the standard array, there was a fourfold increase in the US-facilitated transmission over that in the control. These promising results indicate that low-frequency US can be used in a practical device for enhanced transport across the stratum corneum.

Authors+Show Affiliations

Department of Bioengineering, College of Engineering, The Pennsylvania State University, University Park, PA 16802, USA. nbs@engr.psu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12659919

Citation

Smith, Nadine Barrie, et al. "Ultrasound-mediated Transdermal Transport of Insulin in Vitro Through Human Skin Using Novel Transducer Designs." Ultrasound in Medicine & Biology, vol. 29, no. 2, 2003, pp. 311-7.
Smith NB, Lee S, Maione E, et al. Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs. Ultrasound Med Biol. 2003;29(2):311-7.
Smith, N. B., Lee, S., Maione, E., Roy, R. B., McElligott, S., & Shung, K. K. (2003). Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs. Ultrasound in Medicine & Biology, 29(2), 311-7.
Smith NB, et al. Ultrasound-mediated Transdermal Transport of Insulin in Vitro Through Human Skin Using Novel Transducer Designs. Ultrasound Med Biol. 2003;29(2):311-7. PubMed PMID: 12659919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrasound-mediated transdermal transport of insulin in vitro through human skin using novel transducer designs. AU - Smith,Nadine Barrie, AU - Lee,Seungjun, AU - Maione,Emiliano, AU - Roy,Ram B, AU - McElligott,Sandra, AU - Shung,K Kirk, PY - 2003/3/28/pubmed PY - 2003/7/10/medline PY - 2003/3/28/entrez SP - 311 EP - 7 JF - Ultrasound in medicine & biology JO - Ultrasound Med Biol VL - 29 IS - 2 N2 - Recent studies have shown that ultrasound (US)-mediated transdermal drug delivery offers a promising potential for noninvasive drug administration. The purpose of this study was to improve low-frequency (20 kHz) US methods for enhancing the transport of insulin in vitro across human skin. The feasibility of using US produced by small, lightweight novel transducers was explored for enhancing the transport of insulin across skin. Previous investigators have used US devices such as large, heavy sonicators or commercially obtained transducers for this type of research. The experiments carried out in this study used two low-profile novel US transducer arrays, the stack and standard array, for improved transport of insulin. The stack array generated a spatial peak temporal peak intensity (I(SPTP)) of 15.4 +/- 0.6 mW/cm(2) and the standard array had an I(SPTP) of 173.7 +/- 1.2 mW/cm(2). Spectrophotometeric absorption techniques were used for determining insulin transport in vitro across human skin. Compared with passive transmission (4.1 +/- 0.5 U) over an exposure period of 1 h, the standard array facilitated over a sevenfold increase in the noninvasive transdermal transport of Humulin R insulin (45.9 +/- 12.9 U). Using Humalog insulin with the standard array, there was a fourfold increase in the US-facilitated transmission over that in the control. These promising results indicate that low-frequency US can be used in a practical device for enhanced transport across the stratum corneum. SN - 0301-5629 UR - https://www.unboundmedicine.com/medline/citation/12659919/Ultrasound_mediated_transdermal_transport_of_insulin_in_vitro_through_human_skin_using_novel_transducer_designs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301562902007068 DB - PRIME DP - Unbound Medicine ER -