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[Folic acid and prevention of anomalies of foetal neural tube closing in women treated for epilepsy].
Rev Neurol (Paris) 2003; 159(2):165-70RN

Abstract

Anomalies of neural tube closing are serious malformations which are encountered most often in babies of epileptic women treated with anti-epileptic drugs during pregnancy. Dietary supplementation of folic acid has been suggested as a preventive measure in these cases, based on the long suspected association between folic acid deficiency and congenital malformations. Folic acid deficiency usually results from insufficient dietary intake, or increased requirements during pregnancy. Moreover, certain anti-epileptic drugs can reduce the availability of folic acid. In secondary prevention, the protective effect of folic acid has been clearly demonstrated, whilst epidemiological data suggest that such treatment is also useful in primary prevention. With respect to women with epilepsy, there is a clear consensus as to the interest of dietary supplementation with folic acid before conception and during the first three months of pregnancy (the period of organogenesis), particularly given the fact that side-effects are extremely rare. Apart from recurrence prevention, where a dose of 4mg/day is recommended, no standard dosing guidelines exist. We would suggest that this same dose be used for epileptic patients in pregnancy, particularly if they are treated with barbamazepine or valproic acid.

Authors+Show Affiliations

Service de Neurologie, CHU Hôpital Central, 29, avenue Marechal de Lattre de Tassigny, 54035 Nancy cedex, France.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

12660568

Citation

Weber, M, and M Dib. "[Folic Acid and Prevention of Anomalies of Foetal Neural Tube Closing in Women Treated for Epilepsy]." Revue Neurologique, vol. 159, no. 2, 2003, pp. 165-70.
Weber M, Dib M. [Folic acid and prevention of anomalies of foetal neural tube closing in women treated for epilepsy]. Rev Neurol (Paris). 2003;159(2):165-70.
Weber, M., & Dib, M. (2003). [Folic acid and prevention of anomalies of foetal neural tube closing in women treated for epilepsy]. Revue Neurologique, 159(2), pp. 165-70.
Weber M, Dib M. [Folic Acid and Prevention of Anomalies of Foetal Neural Tube Closing in Women Treated for Epilepsy]. Rev Neurol (Paris). 2003;159(2):165-70. PubMed PMID: 12660568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Folic acid and prevention of anomalies of foetal neural tube closing in women treated for epilepsy]. AU - Weber,M, AU - Dib,M, PY - 2003/3/28/pubmed PY - 2003/4/19/medline PY - 2003/3/28/entrez SP - 165 EP - 70 JF - Revue neurologique JO - Rev. Neurol. (Paris) VL - 159 IS - 2 N2 - Anomalies of neural tube closing are serious malformations which are encountered most often in babies of epileptic women treated with anti-epileptic drugs during pregnancy. Dietary supplementation of folic acid has been suggested as a preventive measure in these cases, based on the long suspected association between folic acid deficiency and congenital malformations. Folic acid deficiency usually results from insufficient dietary intake, or increased requirements during pregnancy. Moreover, certain anti-epileptic drugs can reduce the availability of folic acid. In secondary prevention, the protective effect of folic acid has been clearly demonstrated, whilst epidemiological data suggest that such treatment is also useful in primary prevention. With respect to women with epilepsy, there is a clear consensus as to the interest of dietary supplementation with folic acid before conception and during the first three months of pregnancy (the period of organogenesis), particularly given the fact that side-effects are extremely rare. Apart from recurrence prevention, where a dose of 4mg/day is recommended, no standard dosing guidelines exist. We would suggest that this same dose be used for epileptic patients in pregnancy, particularly if they are treated with barbamazepine or valproic acid. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/12660568/[Folic_acid_and_prevention_of_anomalies_of_foetal_neural_tube_closing_in_women_treated_for_epilepsy]_ L2 - http://www.em-consulte.com/retrieve/pii/MDOI-RN-02-2003-159-2-0035-3787-101019-ART3 DB - PRIME DP - Unbound Medicine ER -