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Guieranone A, a naphthyl butenone from the leaves of Guiera senegalensis with antifungal activity.
J Nat Prod. 2003 Mar; 66(3):447-9.JN

Abstract

A new methoxylated naphthyl butenone, guieranone A (1), was isolated from the leaves of Guiera senegalensis. Its structure was elucidated as (2E)-1-(1,3,6,8-tetramethoxy-2-naphthyl)but-2-en-1-one, on the basis of spectroscopic data. Also isolated were two known naphthopyrones, 5-methyldihydroflavasperone (2) and 5-methylflavasperone (3). Guieranone (1) exhibited potent antifungal activity against Cladosporium cucumerinum and is the first naphthyl ketone derivative to have been isolated from the family Combretaceae.

Authors+Show Affiliations

Silva O
Centro de Estudos de Ciências Farmacêuticas, Laboratory of Pharmacognosy, Faculty of Pharmacy, University of Lisbon, Av. das Forças Armadas, 1649-019 Lisbon, Portugal.
Gomes ET
No affiliation info available

MeSH

Antifungal AgentsButanonesCladosporiumCombretaceaeGuineaMedicine, African TraditionalMolecular StructureNaphthalenesPlant LeavesPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12662113

Citation

Silva, Olga, and Elsa T. Gomes. "Guieranone A, a Naphthyl Butenone From the Leaves of Guiera Senegalensis With Antifungal Activity." Journal of Natural Products, vol. 66, no. 3, 2003, pp. 447-9.
Silva O, Gomes ET. Guieranone A, a naphthyl butenone from the leaves of Guiera senegalensis with antifungal activity. J Nat Prod. 2003;66(3):447-9.
Silva, O., & Gomes, E. T. (2003). Guieranone A, a naphthyl butenone from the leaves of Guiera senegalensis with antifungal activity. Journal of Natural Products, 66(3), 447-9.
Silva O, Gomes ET. Guieranone A, a Naphthyl Butenone From the Leaves of Guiera Senegalensis With Antifungal Activity. J Nat Prod. 2003;66(3):447-9. PubMed PMID: 12662113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guieranone A, a naphthyl butenone from the leaves of Guiera senegalensis with antifungal activity. AU - Silva,Olga, AU - Gomes,Elsa T, PY - 2003/3/29/pubmed PY - 2003/9/5/medline PY - 2003/3/29/entrez SP - 447 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 66 IS - 3 N2 - A new methoxylated naphthyl butenone, guieranone A (1), was isolated from the leaves of Guiera senegalensis. Its structure was elucidated as (2E)-1-(1,3,6,8-tetramethoxy-2-naphthyl)but-2-en-1-one, on the basis of spectroscopic data. Also isolated were two known naphthopyrones, 5-methyldihydroflavasperone (2) and 5-methylflavasperone (3). Guieranone (1) exhibited potent antifungal activity against Cladosporium cucumerinum and is the first naphthyl ketone derivative to have been isolated from the family Combretaceae. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/12662113/Guieranone_A_a_naphthyl_butenone_from_the_leaves_of_Guiera_senegalensis_with_antifungal_activity_ DB - PRIME DP - Unbound Medicine ER -