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Anxiolytics: past, present, and future agents.
J Clin Psychiatry. 2003; 64 Suppl 3:3-6.JC

Abstract

Although anxiety disorders were classified as neurotic disorders and not systematically studied before DSM-III, researchers and clinicians have been searching for effective, safe agents to treat anxiety symptoms and disorders for over a century. In that time, barbiturates, benzodiazepines, and many classes of antidepressants have been used as anxiolytics, all with side effect profiles that made them less than optimal treatments for anxiety. The recognition of the role of GABA in anxiety disorders has led researchers to develop anxiolytics that target GABA. The long-sought-after class of anxiolytics that are both effective and safe may be found in the new research being conducted with agents that selectively target GABA receptors and their subtypes.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga 30322, USA. cnemero@emory.edu

Pub Type(s)

Comparative Study
Historical Article
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12662127

Citation

Nemeroff, Charles B.. "Anxiolytics: Past, Present, and Future Agents." The Journal of Clinical Psychiatry, vol. 64 Suppl 3, 2003, pp. 3-6.
Nemeroff CB. Anxiolytics: past, present, and future agents. J Clin Psychiatry. 2003;64 Suppl 3:3-6.
Nemeroff, C. B. (2003). Anxiolytics: past, present, and future agents. The Journal of Clinical Psychiatry, 64 Suppl 3, 3-6.
Nemeroff CB. Anxiolytics: Past, Present, and Future Agents. J Clin Psychiatry. 2003;64 Suppl 3:3-6. PubMed PMID: 12662127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytics: past, present, and future agents. A1 - Nemeroff,Charles B, PY - 2003/3/29/pubmed PY - 2003/4/23/medline PY - 2003/3/29/entrez SP - 3 EP - 6 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 64 Suppl 3 N2 - Although anxiety disorders were classified as neurotic disorders and not systematically studied before DSM-III, researchers and clinicians have been searching for effective, safe agents to treat anxiety symptoms and disorders for over a century. In that time, barbiturates, benzodiazepines, and many classes of antidepressants have been used as anxiolytics, all with side effect profiles that made them less than optimal treatments for anxiety. The recognition of the role of GABA in anxiety disorders has led researchers to develop anxiolytics that target GABA. The long-sought-after class of anxiolytics that are both effective and safe may be found in the new research being conducted with agents that selectively target GABA receptors and their subtypes. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/12662127/Anxiolytics:_past_present_and_future_agents_ L2 - http://www.psychiatrist.com/jcp/article/pages/2003/v64s03/v64s0301.aspx DB - PRIME DP - Unbound Medicine ER -