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Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders.
J Clin Psychiatry. 2003; 64 Suppl 3:7-14.JC

Abstract

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and is integral to managing brain excitability. GABA concentrations vary according to age, gender, and brain region. Magnetic resonance spectroscopy (MRS), with editing or with localized 2-dimensional chemical shift methods, can measure GABA levels in vivo, ex vivo, or in vitro, particularly at ultra-high magnetic field strengths. Proton ((1)H) MRS studies have found reduced or abnormal GABA concentrations in several neuropsychiatric disorders, including epilepsy, anxiety disorders, major depression, and drug addiction. Disorders with low GABA levels may be treated by augmentation of GABAergic function, such as by medications that block the degradation or reuptake of GABA. Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder.

Authors+Show Affiliations

Brookhaven National Laboratory, Upton, NY 11973, USA. changl@bnl.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12662128

Citation

Chang, Linda, et al. "Magnetic Resonance Spectroscopy Studies of GABA in Neuropsychiatric Disorders." The Journal of Clinical Psychiatry, vol. 64 Suppl 3, 2003, pp. 7-14.
Chang L, Cloak CC, Ernst T. Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders. J Clin Psychiatry. 2003;64 Suppl 3:7-14.
Chang, L., Cloak, C. C., & Ernst, T. (2003). Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders. The Journal of Clinical Psychiatry, 64 Suppl 3, 7-14.
Chang L, Cloak CC, Ernst T. Magnetic Resonance Spectroscopy Studies of GABA in Neuropsychiatric Disorders. J Clin Psychiatry. 2003;64 Suppl 3:7-14. PubMed PMID: 12662128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders. AU - Chang,Linda, AU - Cloak,Christine C, AU - Ernst,Thomas, PY - 2003/3/29/pubmed PY - 2003/4/23/medline PY - 2003/3/29/entrez SP - 7 EP - 14 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 64 Suppl 3 N2 - Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and is integral to managing brain excitability. GABA concentrations vary according to age, gender, and brain region. Magnetic resonance spectroscopy (MRS), with editing or with localized 2-dimensional chemical shift methods, can measure GABA levels in vivo, ex vivo, or in vitro, particularly at ultra-high magnetic field strengths. Proton ((1)H) MRS studies have found reduced or abnormal GABA concentrations in several neuropsychiatric disorders, including epilepsy, anxiety disorders, major depression, and drug addiction. Disorders with low GABA levels may be treated by augmentation of GABAergic function, such as by medications that block the degradation or reuptake of GABA. Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/12662128/Magnetic_resonance_spectroscopy_studies_of_GABA_in_neuropsychiatric_disorders_ L2 - http://www.psychiatrist.com/jcp/article/pages/2003/v64s03/v64s0302.aspx DB - PRIME DP - Unbound Medicine ER -