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The role of GABA in anxiety disorders.
J Clin Psychiatry. 2003; 64 Suppl 3:21-7.JC

Abstract

Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate. Several pharmacologic agents target the GABA system and modulate the overall effect of GABA. This article highlights multiple neurobiological interactions that play a role in anxiety and reviews selected studies of plasma neurosteroid levels, plasma GABA levels, and benzodiazepine binding site sensitivity and density in patients with anxiety disorders. The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders.

Authors+Show Affiliations

Medical University of South Carolina, Charleston, USA. lydiardb@mindyourhealth.net

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12662130

Citation

Lydiard, R Bruce. "The Role of GABA in Anxiety Disorders." The Journal of Clinical Psychiatry, vol. 64 Suppl 3, 2003, pp. 21-7.
Lydiard RB. The role of GABA in anxiety disorders. J Clin Psychiatry. 2003;64 Suppl 3:21-7.
Lydiard, R. B. (2003). The role of GABA in anxiety disorders. The Journal of Clinical Psychiatry, 64 Suppl 3, 21-7.
Lydiard RB. The Role of GABA in Anxiety Disorders. J Clin Psychiatry. 2003;64 Suppl 3:21-7. PubMed PMID: 12662130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of GABA in anxiety disorders. A1 - Lydiard,R Bruce, PY - 2003/3/29/pubmed PY - 2003/4/23/medline PY - 2003/3/29/entrez SP - 21 EP - 7 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 64 Suppl 3 N2 - Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate. Several pharmacologic agents target the GABA system and modulate the overall effect of GABA. This article highlights multiple neurobiological interactions that play a role in anxiety and reviews selected studies of plasma neurosteroid levels, plasma GABA levels, and benzodiazepine binding site sensitivity and density in patients with anxiety disorders. The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/12662130/The_role_of_GABA_in_anxiety_disorders_ L2 - http://www.psychiatrist.com/jcp/article/pages/2003/v64s03/v64s0304.aspx DB - PRIME DP - Unbound Medicine ER -