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Nutritional management of rheumatoid arthritis: a review of the evidence.
J Hum Nutr Diet 2003; 16(2):97-109JH

Abstract

Rheumatoid arthritis (RA) is a debilitating disease and is associated with increased risk of cardiovascular disease and osteoporosis. Poor nutrient status in RA patients has been reported and some drug therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prescribed to alleviate RA symptoms, may increase the requirement for some nutrients and reduce their absorption. This paper reviews the scientific evidence for the role of diet and nutrient supplementation in the management of RA, by alleviating symptoms, decreasing progression of the disease or by reducing the reliance on, or combating the side-effects of, NSAIDs. Supplementation with long-chain n-3 polyunsaturated fatty acids (PUFA) consistently demonstrates an improvement in symptoms and a reduction in NSAID usage. Evidence relating to other fatty acids, antioxidants, zinc, iron, folate, other B vitamins, calcium, vitamin D and fluoride are also considered. The present evidence suggests that RA patients should consume a balanced diet rich in long-chain n-3 PUFA and antioxidants. More randomized long-term studies are needed to provide evidence for the benefits of specific nutritional supplementation and to determine optimum intake, particularly for n-3 PUFA and antioxidants.

Authors+Show Affiliations

MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, UK. kirsten.rennie@mrc-hnr.cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12662368

Citation

Rennie, K L., et al. "Nutritional Management of Rheumatoid Arthritis: a Review of the Evidence." Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, vol. 16, no. 2, 2003, pp. 97-109.
Rennie KL, Hughes J, Lang R, et al. Nutritional management of rheumatoid arthritis: a review of the evidence. J Hum Nutr Diet. 2003;16(2):97-109.
Rennie, K. L., Hughes, J., Lang, R., & Jebb, S. A. (2003). Nutritional management of rheumatoid arthritis: a review of the evidence. Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association, 16(2), pp. 97-109.
Rennie KL, et al. Nutritional Management of Rheumatoid Arthritis: a Review of the Evidence. J Hum Nutr Diet. 2003;16(2):97-109. PubMed PMID: 12662368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional management of rheumatoid arthritis: a review of the evidence. AU - Rennie,K L, AU - Hughes,J, AU - Lang,R, AU - Jebb,S A, PY - 2003/3/29/pubmed PY - 2003/7/24/medline PY - 2003/3/29/entrez SP - 97 EP - 109 JF - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JO - J Hum Nutr Diet VL - 16 IS - 2 N2 - Rheumatoid arthritis (RA) is a debilitating disease and is associated with increased risk of cardiovascular disease and osteoporosis. Poor nutrient status in RA patients has been reported and some drug therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prescribed to alleviate RA symptoms, may increase the requirement for some nutrients and reduce their absorption. This paper reviews the scientific evidence for the role of diet and nutrient supplementation in the management of RA, by alleviating symptoms, decreasing progression of the disease or by reducing the reliance on, or combating the side-effects of, NSAIDs. Supplementation with long-chain n-3 polyunsaturated fatty acids (PUFA) consistently demonstrates an improvement in symptoms and a reduction in NSAID usage. Evidence relating to other fatty acids, antioxidants, zinc, iron, folate, other B vitamins, calcium, vitamin D and fluoride are also considered. The present evidence suggests that RA patients should consume a balanced diet rich in long-chain n-3 PUFA and antioxidants. More randomized long-term studies are needed to provide evidence for the benefits of specific nutritional supplementation and to determine optimum intake, particularly for n-3 PUFA and antioxidants. SN - 0952-3871 UR - https://www.unboundmedicine.com/medline/citation/12662368/Nutritional_management_of_rheumatoid_arthritis:_a_review_of_the_evidence_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0952-3871&date=2003&volume=16&issue=2&spage=97 DB - PRIME DP - Unbound Medicine ER -