Tags

Type your tag names separated by a space and hit enter

Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids.
Am J Clin Nutr 2003; 77(4):796-802AJ

Abstract

BACKGROUND

The Jewish population of Israel consumes a diet rich in n-6 polyunsaturated fatty acids (PUFAs), principally linoleic acid. The consequences of this diet for ischemic heart disease (IHD) remain unclear.

OBJECTIVE

We assessed the association of adipose tissue n-6 fatty acids, which are derived entirely from the diet, with acute myocardial infarction (AMI).

DESIGN

A total of 180 cases and 492 IHD-free controls aged 25-64 were included in a population-based case-control study of Jerusalem residents hospitalized with a first AMI. Diet was assessed by the use of a food-frequency questionnaire and adipose tissue fatty acids by gas chromatography of biopsy samples taken from subcutaneous gluteal tissue. The data were analyzed by multivariate logistic regression.

RESULTS

Dietary PUFAs (: 10.1% of energy) correlated (r = 0.43, P < 0.001) with adipose tissue linoleic acid, which constituted 25.6% of storage fatty acids. High intakes of linoleic acid were not associated with excess risk of AMI (age- and sex-adjusted odds ratio for the third versus the first tertile: 0.96; 95% CI: 0.62, 1.48; NS). In contrast, arachidonic acid, the long chain n-6 derivative of linoleic acid, was positively associated with AMI (age- and sex-adjusted odds ratio: 2.12; 95% CI: 1.33, 3.36; P = 0.004). With multivariate adjustment, there was no evidence for an adverse association of linoleic acid with AMI, whereas the risk associated with arachidonic acid persisted, albeit attenuated.

CONCLUSIONS

A very high linoleic acid intake does not appear to confer increased risk of nonfatal AMI. Nonetheless, the increased risk associated with arachidonic acid, a finding that requires confirmation, tempers an inference that diets rich in n-6 fatty acids are safe vis-à-vis coronary health.

Authors+Show Affiliations

Epidemiology Unit, Department of Social Medicine, Hadassah University Hospital, Jerusalem, Israel. jeremy1@vms.huji.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12663274

Citation

Kark, Jeremy D., et al. "Adipose Tissue N-6 Fatty Acids and Acute Myocardial Infarction in a Population Consuming a Diet High in Polyunsaturated Fatty Acids." The American Journal of Clinical Nutrition, vol. 77, no. 4, 2003, pp. 796-802.
Kark JD, Kaufmann NA, Binka F, et al. Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. Am J Clin Nutr. 2003;77(4):796-802.
Kark, J. D., Kaufmann, N. A., Binka, F., Goldberger, N., & Berry, E. M. (2003). Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. The American Journal of Clinical Nutrition, 77(4), pp. 796-802.
Kark JD, et al. Adipose Tissue N-6 Fatty Acids and Acute Myocardial Infarction in a Population Consuming a Diet High in Polyunsaturated Fatty Acids. Am J Clin Nutr. 2003;77(4):796-802. PubMed PMID: 12663274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. AU - Kark,Jeremy D, AU - Kaufmann,Nathan A, AU - Binka,Fred, AU - Goldberger,Nehama, AU - Berry,Elliot M, PY - 2003/3/29/pubmed PY - 2003/4/25/medline PY - 2003/3/29/entrez SP - 796 EP - 802 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 77 IS - 4 N2 - BACKGROUND: The Jewish population of Israel consumes a diet rich in n-6 polyunsaturated fatty acids (PUFAs), principally linoleic acid. The consequences of this diet for ischemic heart disease (IHD) remain unclear. OBJECTIVE: We assessed the association of adipose tissue n-6 fatty acids, which are derived entirely from the diet, with acute myocardial infarction (AMI). DESIGN: A total of 180 cases and 492 IHD-free controls aged 25-64 were included in a population-based case-control study of Jerusalem residents hospitalized with a first AMI. Diet was assessed by the use of a food-frequency questionnaire and adipose tissue fatty acids by gas chromatography of biopsy samples taken from subcutaneous gluteal tissue. The data were analyzed by multivariate logistic regression. RESULTS: Dietary PUFAs (: 10.1% of energy) correlated (r = 0.43, P < 0.001) with adipose tissue linoleic acid, which constituted 25.6% of storage fatty acids. High intakes of linoleic acid were not associated with excess risk of AMI (age- and sex-adjusted odds ratio for the third versus the first tertile: 0.96; 95% CI: 0.62, 1.48; NS). In contrast, arachidonic acid, the long chain n-6 derivative of linoleic acid, was positively associated with AMI (age- and sex-adjusted odds ratio: 2.12; 95% CI: 1.33, 3.36; P = 0.004). With multivariate adjustment, there was no evidence for an adverse association of linoleic acid with AMI, whereas the risk associated with arachidonic acid persisted, albeit attenuated. CONCLUSIONS: A very high linoleic acid intake does not appear to confer increased risk of nonfatal AMI. Nonetheless, the increased risk associated with arachidonic acid, a finding that requires confirmation, tempers an inference that diets rich in n-6 fatty acids are safe vis-à-vis coronary health. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/12663274/Adipose_tissue_n_6_fatty_acids_and_acute_myocardial_infarction_in_a_population_consuming_a_diet_high_in_polyunsaturated_fatty_acids_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/77.4.796 DB - PRIME DP - Unbound Medicine ER -