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[Prospective study for cut-off points of body mass index in Chinese adults].

Abstract

OBJECTIVE

To verify the optimal cut-off point for overweight and obesity in Chinese adults based on the relationship of body mass index (BMI) to all-cause mortality and incidence of coronary heart disease (CHD) and stroke from pooled data of Chinese cohorts.

METHODS

Pooling the data of four Chinese cohorts, to analyze the age-adjusted all-cause mortality by strata of BMI, and to repeat the analyses after excluding deaths within the first three years of follow-up and after excluding the smokers. Analyzing the age-adjusted incidence of CHD and stroke by strata of BMI. Pooling the Cox regression coefficients of BMI to incidence of CHD or stroke of different cohorts using the method of weighting by inverse of variance.

RESULTS

All together 76,227 people from 4 cohorts were enrolled, with 745,346 person-year of follow-up. All-cause mortality by strata of BMI showed a U shaped curve, even after excluding deaths from the first three years and the smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. Incidence rates of CHD and stroke increased when the level of BMI was increasing. Results of Cox regression showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m(2) increase in baseline BMI might cause 15.4%, 6.1% and 18.8% in incidence of CHD, stroke and ischaemic stroke. Reduction of increased BMI to the level of under 24 might prevent incidence of CHD by 11% and that of stroke by 15% for men and 22% CHD and stroke for women in the population.

CONCLUSION

Attempt to define the levels of BMI < 18.5 for underweight, 24 to 27.9 for overweight and > or = 28 for obesity seemed to be appropriate cut-off points for Chinese adults.

Authors+Show Affiliations

Department of Epidemiology, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12667353

Citation

Zhou, Beifan, and Coorperative Meta-Analysis Group Of Working Group On Obesity In China. "[Prospective Study for Cut-off Points of Body Mass Index in Chinese Adults]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 23, no. 6, 2002, pp. 431-4.
Zhou B, Coorperative Meta-Analysis Group Of Working Group On Obesity In China. [Prospective study for cut-off points of body mass index in Chinese adults]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23(6):431-4.
Zhou, B. (2002). [Prospective study for cut-off points of body mass index in Chinese adults]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 23(6), pp. 431-4.
Zhou B, Coorperative Meta-Analysis Group Of Working Group On Obesity In China. [Prospective Study for Cut-off Points of Body Mass Index in Chinese Adults]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002;23(6):431-4. PubMed PMID: 12667353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prospective study for cut-off points of body mass index in Chinese adults]. AU - Zhou,Beifan, AU - ,, PY - 2003/4/2/pubmed PY - 2003/9/26/medline PY - 2003/4/2/entrez SP - 431 EP - 4 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 23 IS - 6 N2 - OBJECTIVE: To verify the optimal cut-off point for overweight and obesity in Chinese adults based on the relationship of body mass index (BMI) to all-cause mortality and incidence of coronary heart disease (CHD) and stroke from pooled data of Chinese cohorts. METHODS: Pooling the data of four Chinese cohorts, to analyze the age-adjusted all-cause mortality by strata of BMI, and to repeat the analyses after excluding deaths within the first three years of follow-up and after excluding the smokers. Analyzing the age-adjusted incidence of CHD and stroke by strata of BMI. Pooling the Cox regression coefficients of BMI to incidence of CHD or stroke of different cohorts using the method of weighting by inverse of variance. RESULTS: All together 76,227 people from 4 cohorts were enrolled, with 745,346 person-year of follow-up. All-cause mortality by strata of BMI showed a U shaped curve, even after excluding deaths from the first three years and the smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. Incidence rates of CHD and stroke increased when the level of BMI was increasing. Results of Cox regression showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m(2) increase in baseline BMI might cause 15.4%, 6.1% and 18.8% in incidence of CHD, stroke and ischaemic stroke. Reduction of increased BMI to the level of under 24 might prevent incidence of CHD by 11% and that of stroke by 15% for men and 22% CHD and stroke for women in the population. CONCLUSION: Attempt to define the levels of BMI < 18.5 for underweight, 24 to 27.9 for overweight and > or = 28 for obesity seemed to be appropriate cut-off points for Chinese adults. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/12667353/[Prospective_study_for_cut_off_points_of_body_mass_index_in_Chinese_adults]_ L2 - https://ClinicalTrials.gov/search/term=12667353 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -