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Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica.
Circulation 2003; 107(12):1586-91Circ

Abstract

BACKGROUND

Alpha-linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica.

METHODS AND RESULTS

The 482 case patients with a first nonfatal acute MI and 482 population control subjects were matched by age, sex, and area of residence. Fatty acids were assessed by gas-liquid chromatography in adipose tissue samples collected from all subjects. ORs and 95% CIs were calculated from multivariate conditional logistic regression models. Subjects in the top quintiles of adipose tissue alpha-linolenic acid had a lower risk of MI than those in the lowest quintile: OR (95% CI), 1.00; 0.80 (0.52 to 1.24); 0.53 (0.34 to 0.82); 0.44 (0.28 to 0.67); and 0.37 (0.24 to 0.59); test for trend, P<0.0001. This association was strengthened after adjustment for established MI risk factors, including smoking, physical activity, income, and adipose tissue linoleic acid and trans fatty acids (OR for the top versus lowest quintile, 0.23; 95% CI, 0.10 to 0.50; test for trend, P<0.0001). Further adjustment for the intake of saturated fat, fiber, alcohol, and vitamin E did not change this association (OR for the top versus lowest quintile, 0.23; 95% CI, 0.10 to 0.55; test for trend, P<0.0001).

CONCLUSIONS

The inverse association observed between alpha-linolenic acid and nonfatal acute MI suggests that consumption of vegetable oils rich in alpha-linolenic acid confers important protection against cardiovascular disease.

Authors+Show Affiliations

Department of Nutrition, Room 353A, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA. hcampos@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12668490

Citation

Baylin, Ana, et al. "Adipose Tissue Alpha-linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica." Circulation, vol. 107, no. 12, 2003, pp. 1586-91.
Baylin A, Kabagambe EK, Ascherio A, et al. Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. Circulation. 2003;107(12):1586-91.
Baylin, A., Kabagambe, E. K., Ascherio, A., Spiegelman, D., & Campos, H. (2003). Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. Circulation, 107(12), pp. 1586-91.
Baylin A, et al. Adipose Tissue Alpha-linolenic Acid and Nonfatal Acute Myocardial Infarction in Costa Rica. Circulation. 2003 Apr 1;107(12):1586-91. PubMed PMID: 12668490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. AU - Baylin,Ana, AU - Kabagambe,Edmond K, AU - Ascherio,Alberto, AU - Spiegelman,Donna, AU - Campos,Hannia, Y1 - 2003/03/10/ PY - 2003/4/2/pubmed PY - 2003/4/12/medline PY - 2003/4/2/entrez SP - 1586 EP - 91 JF - Circulation JO - Circulation VL - 107 IS - 12 N2 - BACKGROUND: Alpha-linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica. METHODS AND RESULTS: The 482 case patients with a first nonfatal acute MI and 482 population control subjects were matched by age, sex, and area of residence. Fatty acids were assessed by gas-liquid chromatography in adipose tissue samples collected from all subjects. ORs and 95% CIs were calculated from multivariate conditional logistic regression models. Subjects in the top quintiles of adipose tissue alpha-linolenic acid had a lower risk of MI than those in the lowest quintile: OR (95% CI), 1.00; 0.80 (0.52 to 1.24); 0.53 (0.34 to 0.82); 0.44 (0.28 to 0.67); and 0.37 (0.24 to 0.59); test for trend, P<0.0001. This association was strengthened after adjustment for established MI risk factors, including smoking, physical activity, income, and adipose tissue linoleic acid and trans fatty acids (OR for the top versus lowest quintile, 0.23; 95% CI, 0.10 to 0.50; test for trend, P<0.0001). Further adjustment for the intake of saturated fat, fiber, alcohol, and vitamin E did not change this association (OR for the top versus lowest quintile, 0.23; 95% CI, 0.10 to 0.55; test for trend, P<0.0001). CONCLUSIONS: The inverse association observed between alpha-linolenic acid and nonfatal acute MI suggests that consumption of vegetable oils rich in alpha-linolenic acid confers important protection against cardiovascular disease. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/12668490/Adipose_tissue_alpha_linolenic_acid_and_nonfatal_acute_myocardial_infarction_in_Costa_Rica_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.CIR.0000058165.81208.C6?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -