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A high risk score for coronary heart disease is associated with the metabolic syndrome in 40-year-old men and women.
J Cardiovasc Risk 2003; 10(2):129-35JC

Abstract

OBJECTIVE

Guidelines recommend follow-up of people whose 10-year risk of coronary heart disease (CHD) is > 10%. We calculated CHD risk, number of risk factors and occurrence of the metabolic syndrome among screened 40-year-old men and women.

DESIGN

A total of 1547 women and 1374 men participated in a cardiovascular risk factor screening programme in 1997-1999 in Oslo. Of 387 (13%) recalled for further examination and advice, 337 (87%) attended. We used the National Cholesterol Education Program criteria to define the metabolic syndrome and the Framingham risk score to assess absolute 10-year risk of CHD and counted nine risk factors (male, southeast-Asian origin, low education, smoking, premature familial cardiovascular disease (CVD), hypertension, high waist circumference, impaired fasting glucose or diabetes and high apolipoprotein B).

RESULTS

More than one-third of subjects recalled for hypertension (n = 88) or low high-density lipoprotein (HDL) cholesterol (n = 95) had the metabolic syndrome. Of 55 subjects with a 10-year risk score > 10%, 33 (60%) had the metabolic syndrome. Subjects with the metabolic syndrome had a higher risk score compared with their counterparts (P < 0.001); among men with the metabolic syndrome, the mean +/- SD risk score was 10.0 +/- 4.4%. Subjects with dyslipidaemia [high triglyceride and normal low-density lipoprotein (LDL) cholesterol levels] or combined hyperlipidaemia had a higher risk score and more risk factors compared with subjects with isolated high LDL cholesterol (P < 0.05). Only 12% of subjects with hypertension were taking drugs and of 237 subjects with a lipid disorder, 30% had been given dietary advice and one was taking a lipid-lowering drug.

CONCLUSION

CVD screening should focus on identifying people with features of the metabolic syndrome in this age group. The screening programme uncovered a substantial potential for CVD prevention.

Authors+Show Affiliations

Department of Preventive Cardiology, Ullevål University Hospital, Oslo, Norway. serena.tonstad@ulleval.noNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12668910

Citation

Tonstad, Serena, and Ingvar Hjermann. "A High Risk Score for Coronary Heart Disease Is Associated With the Metabolic Syndrome in 40-year-old Men and Women." Journal of Cardiovascular Risk, vol. 10, no. 2, 2003, pp. 129-35.
Tonstad S, Hjermann I. A high risk score for coronary heart disease is associated with the metabolic syndrome in 40-year-old men and women. J Cardiovasc Risk. 2003;10(2):129-35.
Tonstad, S., & Hjermann, I. (2003). A high risk score for coronary heart disease is associated with the metabolic syndrome in 40-year-old men and women. Journal of Cardiovascular Risk, 10(2), pp. 129-35.
Tonstad S, Hjermann I. A High Risk Score for Coronary Heart Disease Is Associated With the Metabolic Syndrome in 40-year-old Men and Women. J Cardiovasc Risk. 2003;10(2):129-35. PubMed PMID: 12668910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A high risk score for coronary heart disease is associated with the metabolic syndrome in 40-year-old men and women. AU - Tonstad,Serena, AU - Hjermann,Ingvar, PY - 2003/4/2/pubmed PY - 2003/8/13/medline PY - 2003/4/2/entrez SP - 129 EP - 35 JF - Journal of cardiovascular risk JO - J Cardiovasc Risk VL - 10 IS - 2 N2 - OBJECTIVE: Guidelines recommend follow-up of people whose 10-year risk of coronary heart disease (CHD) is > 10%. We calculated CHD risk, number of risk factors and occurrence of the metabolic syndrome among screened 40-year-old men and women. DESIGN: A total of 1547 women and 1374 men participated in a cardiovascular risk factor screening programme in 1997-1999 in Oslo. Of 387 (13%) recalled for further examination and advice, 337 (87%) attended. We used the National Cholesterol Education Program criteria to define the metabolic syndrome and the Framingham risk score to assess absolute 10-year risk of CHD and counted nine risk factors (male, southeast-Asian origin, low education, smoking, premature familial cardiovascular disease (CVD), hypertension, high waist circumference, impaired fasting glucose or diabetes and high apolipoprotein B). RESULTS: More than one-third of subjects recalled for hypertension (n = 88) or low high-density lipoprotein (HDL) cholesterol (n = 95) had the metabolic syndrome. Of 55 subjects with a 10-year risk score > 10%, 33 (60%) had the metabolic syndrome. Subjects with the metabolic syndrome had a higher risk score compared with their counterparts (P < 0.001); among men with the metabolic syndrome, the mean +/- SD risk score was 10.0 +/- 4.4%. Subjects with dyslipidaemia [high triglyceride and normal low-density lipoprotein (LDL) cholesterol levels] or combined hyperlipidaemia had a higher risk score and more risk factors compared with subjects with isolated high LDL cholesterol (P < 0.05). Only 12% of subjects with hypertension were taking drugs and of 237 subjects with a lipid disorder, 30% had been given dietary advice and one was taking a lipid-lowering drug. CONCLUSION: CVD screening should focus on identifying people with features of the metabolic syndrome in this age group. The screening programme uncovered a substantial potential for CVD prevention. SN - 1350-6277 UR - https://www.unboundmedicine.com/medline/citation/12668910/A_high_risk_score_for_coronary_heart_disease_is_associated_with_the_metabolic_syndrome_in_40_year_old_men_and_women_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=12668910.ui DB - PRIME DP - Unbound Medicine ER -