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Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children.
Nutr Metab Cardiovasc Dis. 2002 Dec; 12(6):317-24.NM

Abstract

BACKGROUND AND AIM

Common variations in genes, such as apolipoprotein E (apo E) and cholesteryl ester transfer protein (CETP), are major determinants of plasma lipid and lipoprotein levels. As both apo E and CETP contribute to the reverse transport of cholesterol to the liver, the effects of variations at the CETP locus may very well interact with the apo E genotype.

METHODS AND RESULTS

As part of an ongoing study, the combined effects of the apo E genotype and heterogeneity at the CETP gene locus on plasma lipids and lipoproteins were studied in a birth cohort sample of 257 Dutch prepubescent boys and girls (aged 6.7-8.1 years). The children with an apo E2E3 genotype (carrying the epsilon 2 allele; arg158-->cys) had lower concentrations of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) than those with an apo E4E3 (carrying the epsilon 4 allele; cys112-->arg) or apo E3E3 genotype (homozygous for the parent epsilon 3 allele). These associations were statistically significant in children who were homozygous (p = 0.004 for LDL; p = 0.002 for apo B) or heterozygous (p < 0.0001 for LDL and apo B) for the absence of the Taq-IB polymorphism at the CETP gene locus (B2 allele), but not in those homozygous for the presence of this variant (B1B1). The highest plasma high-density lipoprotein cholesterol (HDL-C) concentrations were observed in children with the CETP B2B2 genotype. The difference in HDL-C levels between the CETP genotype groups was statistically significant only in E2E3 carriers (p = 0.01). The LDL/HDL ratio was significantly lower in E2E3 carriers, but not when combined with a CETP B1B1 genotype.

CONCLUSION

These findings indicate that the apo E genotype and heterogeneity at the CETP gene locus have an additive and interactive influence on plasma lipid and lipoprotein levels in children.

Authors+Show Affiliations

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Human Biology, Maastricht University, Maastricht, The Netherlands. p.rump@medgen.azg.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12669678

Citation

Rump, P, et al. "Interaction Between a Common Variant of the Cholesteryl Ester Transfer Protein Gene and the Apolipoprotein E Polymorphism: Effects On Plasma Lipids and Lipoproteins in a Cohort of 7-year-old Children." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 12, no. 6, 2002, pp. 317-24.
Rump P, Mensink RP, Hornstra G. Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children. Nutr Metab Cardiovasc Dis. 2002;12(6):317-24.
Rump, P., Mensink, R. P., & Hornstra, G. (2002). Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 12(6), 317-24.
Rump P, Mensink RP, Hornstra G. Interaction Between a Common Variant of the Cholesteryl Ester Transfer Protein Gene and the Apolipoprotein E Polymorphism: Effects On Plasma Lipids and Lipoproteins in a Cohort of 7-year-old Children. Nutr Metab Cardiovasc Dis. 2002;12(6):317-24. PubMed PMID: 12669678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children. AU - Rump,P, AU - Mensink,R P, AU - Hornstra,G, PY - 2003/4/3/pubmed PY - 2003/4/26/medline PY - 2003/4/3/entrez SP - 317 EP - 24 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 12 IS - 6 N2 - BACKGROUND AND AIM: Common variations in genes, such as apolipoprotein E (apo E) and cholesteryl ester transfer protein (CETP), are major determinants of plasma lipid and lipoprotein levels. As both apo E and CETP contribute to the reverse transport of cholesterol to the liver, the effects of variations at the CETP locus may very well interact with the apo E genotype. METHODS AND RESULTS: As part of an ongoing study, the combined effects of the apo E genotype and heterogeneity at the CETP gene locus on plasma lipids and lipoproteins were studied in a birth cohort sample of 257 Dutch prepubescent boys and girls (aged 6.7-8.1 years). The children with an apo E2E3 genotype (carrying the epsilon 2 allele; arg158-->cys) had lower concentrations of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) than those with an apo E4E3 (carrying the epsilon 4 allele; cys112-->arg) or apo E3E3 genotype (homozygous for the parent epsilon 3 allele). These associations were statistically significant in children who were homozygous (p = 0.004 for LDL; p = 0.002 for apo B) or heterozygous (p < 0.0001 for LDL and apo B) for the absence of the Taq-IB polymorphism at the CETP gene locus (B2 allele), but not in those homozygous for the presence of this variant (B1B1). The highest plasma high-density lipoprotein cholesterol (HDL-C) concentrations were observed in children with the CETP B2B2 genotype. The difference in HDL-C levels between the CETP genotype groups was statistically significant only in E2E3 carriers (p = 0.01). The LDL/HDL ratio was significantly lower in E2E3 carriers, but not when combined with a CETP B1B1 genotype. CONCLUSION: These findings indicate that the apo E genotype and heterogeneity at the CETP gene locus have an additive and interactive influence on plasma lipid and lipoprotein levels in children. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/12669678/Interaction_between_a_common_variant_of_the_cholesteryl_ester_transfer_protein_gene_and_the_apolipoprotein_E_polymorphism:_effects_on_plasma_lipids_and_lipoproteins_in_a_cohort_of_7_year_old_children_ L2 - https://medlineplus.gov/hdlthegoodcholesterol.html DB - PRIME DP - Unbound Medicine ER -