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The pharmacokinetic factors and bioavailability of rifampicin, isoniazid and pyrazinamid fixed in one dose capsule.
Acta Pol Pharm 2002 Nov-Dec; 59(6):448-52AP

Abstract

A study was performed at the National Tuberculosis and Lung Diseases Research Institute (NTLDRI) in Warsaw according to the protocol by the Ethics Committee of the Institute. The main target of the mentioned study was a comparison of the bioavailability of rifampicin. isoniazid and pyrazinamid fixed together in one capsule with the bioavailability of the same doses of these drugs, which were given separately. The absorption of rifampicin, isoniazid and pyrazinamid were tested after oral administration of each drug in free simultaneous combinations and in a fixed-dose combination of three drugs--Trifazid. The study was carried out as an open randomised crossover experiment comprising 16 volunteers. The results have shown that the pattern of absorption, plasma concentrations and pharmacokinetic parameters were found to be very similar after administration of the drugs in free and fixed combinations. The triple combination of antituberculosis drugs could replace the separate drugs in the treatment of tuberculosis.

Authors+Show Affiliations

National Tuberculosis and Lung Diseases Research Institute, 26 Płocka Str., 01-138 Warsaw, Poland. z.zwolska@igichp.edu.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12669769

Citation

Zwolska, Zofia, et al. "The Pharmacokinetic Factors and Bioavailability of Rifampicin, Isoniazid and Pyrazinamid Fixed in One Dose Capsule." Acta Poloniae Pharmaceutica, vol. 59, no. 6, 2002, pp. 448-52.
Zwolska Z, Augustynowicz-Kopeć E, Niemirowska-Mikulska H. The pharmacokinetic factors and bioavailability of rifampicin, isoniazid and pyrazinamid fixed in one dose capsule. Acta Pol Pharm. 2002;59(6):448-52.
Zwolska, Z., Augustynowicz-Kopeć, E., & Niemirowska-Mikulska, H. (2002). The pharmacokinetic factors and bioavailability of rifampicin, isoniazid and pyrazinamid fixed in one dose capsule. Acta Poloniae Pharmaceutica, 59(6), pp. 448-52.
Zwolska Z, Augustynowicz-Kopeć E, Niemirowska-Mikulska H. The Pharmacokinetic Factors and Bioavailability of Rifampicin, Isoniazid and Pyrazinamid Fixed in One Dose Capsule. Acta Pol Pharm. 2002;59(6):448-52. PubMed PMID: 12669769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pharmacokinetic factors and bioavailability of rifampicin, isoniazid and pyrazinamid fixed in one dose capsule. AU - Zwolska,Zofia, AU - Augustynowicz-Kopeć,Ewa, AU - Niemirowska-Mikulska,Hanna, PY - 2003/4/3/pubmed PY - 2003/4/22/medline PY - 2003/4/3/entrez SP - 448 EP - 52 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 59 IS - 6 N2 - A study was performed at the National Tuberculosis and Lung Diseases Research Institute (NTLDRI) in Warsaw according to the protocol by the Ethics Committee of the Institute. The main target of the mentioned study was a comparison of the bioavailability of rifampicin. isoniazid and pyrazinamid fixed together in one capsule with the bioavailability of the same doses of these drugs, which were given separately. The absorption of rifampicin, isoniazid and pyrazinamid were tested after oral administration of each drug in free simultaneous combinations and in a fixed-dose combination of three drugs--Trifazid. The study was carried out as an open randomised crossover experiment comprising 16 volunteers. The results have shown that the pattern of absorption, plasma concentrations and pharmacokinetic parameters were found to be very similar after administration of the drugs in free and fixed combinations. The triple combination of antituberculosis drugs could replace the separate drugs in the treatment of tuberculosis. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/12669769/The_pharmacokinetic_factors_and_bioavailability_of_rifampicin_isoniazid_and_pyrazinamid_fixed_in_one_dose_capsule_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2002/6/448.pdf DB - PRIME DP - Unbound Medicine ER -