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'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze.
Eur J Neurosci. 2003 Mar; 17(6):1279-86.EJ

Abstract

Significant variability in the effects of cannabinoid CB1 receptor ligands on emotional reactivity in animals and humans suggests that the endocannabinoid system may selectively modulate certain types of anxiety. In view of substantial evidence for qualitative differences in the nature of anxiety elicited on initial and subsequent exposures to the elevated plus-maze, the present studies contrasted the behavioural effects of the selective CB1 receptor antagonist SR141716A (0.1-10.0 mg/kg) and the reference benzodiazepine chlordiazepoxide (CDP, 15 mg/kg) both in maze-naive mice (trial 1) and in mice that had been given a single undrugged exposure to the maze 24 h prior to testing (trial 2). Results confirmed the anxioselective effect of CDP on trial 1 but a complete absence of such activity on trial 2 (i.e. one trial tolerance). In marked contrast, SR141716A had no behavioural effects in maze-naive mice but, at doses of 1.0-3.0 mg/kg (effect maximal at 1.0 mg/kg), significantly reduced anxiety-like responses in maze-experienced animals. Like the effect of CDP on trial 1, the antianxiety profile of SR141716A on plus-maze trial 2 was observed in the absence of any change in general activity levels. The apparent experientially induced 'sensitization' to the anxiolytic-like effects of SR141716A in the plus-maze contrasts markedly with the widely reported loss of benzodiazepine efficacy in test-experienced animals. Data are discussed in relation to the recently described phenotypes of CB1 receptor knockout mice and, in particular, to mounting evidence for the existence of a novel SR141716A-sensitive neuronal cannabinoid receptor.

Authors+Show Affiliations

Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK. johnr@psychology.leeds.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12670316

Citation

Rodgers, R J., et al. "'One-trial Sensitization' to the Anxiolytic-like Effects of Cannabinoid Receptor Antagonist SR141716A in the Mouse Elevated Plus-maze." The European Journal of Neuroscience, vol. 17, no. 6, 2003, pp. 1279-86.
Rodgers RJ, Haller J, Halasz J, et al. 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze. Eur J Neurosci. 2003;17(6):1279-86.
Rodgers, R. J., Haller, J., Halasz, J., & Mikics, E. (2003). 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze. The European Journal of Neuroscience, 17(6), 1279-86.
Rodgers RJ, et al. 'One-trial Sensitization' to the Anxiolytic-like Effects of Cannabinoid Receptor Antagonist SR141716A in the Mouse Elevated Plus-maze. Eur J Neurosci. 2003;17(6):1279-86. PubMed PMID: 12670316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 'One-trial sensitization' to the anxiolytic-like effects of cannabinoid receptor antagonist SR141716A in the mouse elevated plus-maze. AU - Rodgers,R J, AU - Haller,J, AU - Halasz,J, AU - Mikics,E, PY - 2003/4/3/pubmed PY - 2003/6/28/medline PY - 2003/4/3/entrez SP - 1279 EP - 86 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 17 IS - 6 N2 - Significant variability in the effects of cannabinoid CB1 receptor ligands on emotional reactivity in animals and humans suggests that the endocannabinoid system may selectively modulate certain types of anxiety. In view of substantial evidence for qualitative differences in the nature of anxiety elicited on initial and subsequent exposures to the elevated plus-maze, the present studies contrasted the behavioural effects of the selective CB1 receptor antagonist SR141716A (0.1-10.0 mg/kg) and the reference benzodiazepine chlordiazepoxide (CDP, 15 mg/kg) both in maze-naive mice (trial 1) and in mice that had been given a single undrugged exposure to the maze 24 h prior to testing (trial 2). Results confirmed the anxioselective effect of CDP on trial 1 but a complete absence of such activity on trial 2 (i.e. one trial tolerance). In marked contrast, SR141716A had no behavioural effects in maze-naive mice but, at doses of 1.0-3.0 mg/kg (effect maximal at 1.0 mg/kg), significantly reduced anxiety-like responses in maze-experienced animals. Like the effect of CDP on trial 1, the antianxiety profile of SR141716A on plus-maze trial 2 was observed in the absence of any change in general activity levels. The apparent experientially induced 'sensitization' to the anxiolytic-like effects of SR141716A in the plus-maze contrasts markedly with the widely reported loss of benzodiazepine efficacy in test-experienced animals. Data are discussed in relation to the recently described phenotypes of CB1 receptor knockout mice and, in particular, to mounting evidence for the existence of a novel SR141716A-sensitive neuronal cannabinoid receptor. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/12670316/'One_trial_sensitization'_to_the_anxiolytic_like_effects_of_cannabinoid_receptor_antagonist_SR141716A_in_the_mouse_elevated_plus_maze_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2003&volume=17&issue=6&spage=1279 DB - PRIME DP - Unbound Medicine ER -