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0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease.
Mov Disord. 2003 Apr; 18(4):382-8.MD

Abstract

To study the efficacy of 0.2-Hz repetitive transcranial magnetic stimulation (rTMS) on Parkinson's disease (PD), 85 patients with PD were enrolled into three groups: 1). motor cortical, 2). occipital, and 3). sham stimulation. A round coil was centered over the vertex in motor cortical stimulation, and over the inion in occipital stimulation. In one session, 100 stimuli of 0.2-Hz rTMS at an intensity of 1.1 times active motor threshold (AMT) were given. In sham stimulation, electric currents were given with electrodes fixed on the head to mimic the sensation in real stimulation. Each session was carried out once a week for the first 8 weeks. The Unified Parkinson Disease Rating Scale (UPDRS), Hamilton Rating Scale for Depression (HRSD) and subjective score (visual analogue scale) were assessed. There were no significant differences in clinical features among the three groups. Total and motor score of UPDRS were improved to the same extent by rTMS over Cz, inion, and sham stimulation. HRSD was improved by rTMS over Cz and sham stimulation in the same manner. Subjective score was not significantly improved by any methods of stimulation. 0.2-Hz rTMS at an intensity of 1.1 x AMT has only a placebo effect on PD. Our realistic sham stimulation maneuver must produce powerful placebo effects as a real stimulation.

Authors+Show Affiliations

Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Evaluation Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12671943

Citation

Okabe, Shingo, et al. "0.2-Hz Repetitive Transcranial Magnetic Stimulation Has No Add-on Effects as Compared to a Realistic Sham Stimulation in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 18, no. 4, 2003, pp. 382-8.
Okabe S, Ugawa Y, Kanazawa I, et al. 0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease. Mov Disord. 2003;18(4):382-8.
Okabe, S., Ugawa, Y., & Kanazawa, I. (2003). 0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 18(4), 382-8.
Okabe S, et al. 0.2-Hz Repetitive Transcranial Magnetic Stimulation Has No Add-on Effects as Compared to a Realistic Sham Stimulation in Parkinson's Disease. Mov Disord. 2003;18(4):382-8. PubMed PMID: 12671943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson's disease. AU - Okabe,Shingo, AU - Ugawa,Yoshikazu, AU - Kanazawa,Ichiro, AU - ,, PY - 2003/4/3/pubmed PY - 2003/7/29/medline PY - 2003/4/3/entrez SP - 382 EP - 8 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 18 IS - 4 N2 - To study the efficacy of 0.2-Hz repetitive transcranial magnetic stimulation (rTMS) on Parkinson's disease (PD), 85 patients with PD were enrolled into three groups: 1). motor cortical, 2). occipital, and 3). sham stimulation. A round coil was centered over the vertex in motor cortical stimulation, and over the inion in occipital stimulation. In one session, 100 stimuli of 0.2-Hz rTMS at an intensity of 1.1 times active motor threshold (AMT) were given. In sham stimulation, electric currents were given with electrodes fixed on the head to mimic the sensation in real stimulation. Each session was carried out once a week for the first 8 weeks. The Unified Parkinson Disease Rating Scale (UPDRS), Hamilton Rating Scale for Depression (HRSD) and subjective score (visual analogue scale) were assessed. There were no significant differences in clinical features among the three groups. Total and motor score of UPDRS were improved to the same extent by rTMS over Cz, inion, and sham stimulation. HRSD was improved by rTMS over Cz and sham stimulation in the same manner. Subjective score was not significantly improved by any methods of stimulation. 0.2-Hz rTMS at an intensity of 1.1 x AMT has only a placebo effect on PD. Our realistic sham stimulation maneuver must produce powerful placebo effects as a real stimulation. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/12671943/0_2_Hz_repetitive_transcranial_magnetic_stimulation_has_no_add_on_effects_as_compared_to_a_realistic_sham_stimulation_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.10370 DB - PRIME DP - Unbound Medicine ER -