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Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome.
Eur J Immunol. 2003 Apr; 33(4):834-9.EJ

Abstract

Patients with hypereosinophilia frequently suffer from eosinophil-mediated damages of the heart, lungs, skin, and other organs, while some do not. The reason(s) for this difference is not known. We observed that eosinophils from most patients with hypereosinophilia express the alpha-chain of the IL-2 receptor (CD25), and that IL-2 enhances platelet-activating factor-stimulated release of eosinophil cationic protein from CD25-expressing but not from CD25-negative eosinophils. Such a "priming" effect has previously been described for eosinophil hematopoietins. These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites.

Authors+Show Affiliations

Department of Pharmacology, University of Bern, Bern, Switzerland. hus@pki.unibe.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12672048

Citation

Simon, Hans-Uwe, et al. "Interleukin-2 Primes Eosinophil Degranulation in Hypereosinophilia and Wells' Syndrome." European Journal of Immunology, vol. 33, no. 4, 2003, pp. 834-9.
Simon HU, Plötz S, Simon D, et al. Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. Eur J Immunol. 2003;33(4):834-9.
Simon, H. U., Plötz, S., Simon, D., Seitzer, U., Braathen, L. R., Menz, G., Straumann, A., Dummer, R., & Levi-Schaffer, F. (2003). Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. European Journal of Immunology, 33(4), 834-9.
Simon HU, et al. Interleukin-2 Primes Eosinophil Degranulation in Hypereosinophilia and Wells' Syndrome. Eur J Immunol. 2003;33(4):834-9. PubMed PMID: 12672048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. AU - Simon,Hans-Uwe, AU - Plötz,Sabine, AU - Simon,Dagmar, AU - Seitzer,Ulrike, AU - Braathen,Lasse R, AU - Menz,Günter, AU - Straumann,Alex, AU - Dummer,Reinhard, AU - Levi-Schaffer,Francesca, PY - 2003/4/3/pubmed PY - 2003/5/8/medline PY - 2003/4/3/entrez SP - 834 EP - 9 JF - European journal of immunology JO - Eur J Immunol VL - 33 IS - 4 N2 - Patients with hypereosinophilia frequently suffer from eosinophil-mediated damages of the heart, lungs, skin, and other organs, while some do not. The reason(s) for this difference is not known. We observed that eosinophils from most patients with hypereosinophilia express the alpha-chain of the IL-2 receptor (CD25), and that IL-2 enhances platelet-activating factor-stimulated release of eosinophil cationic protein from CD25-expressing but not from CD25-negative eosinophils. Such a "priming" effect has previously been described for eosinophil hematopoietins. These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/12672048/Interleukin_2_primes_eosinophil_degranulation_in_hypereosinophilia_and_Wells'_syndrome_ L2 - https://doi.org/10.1002/eji.200323727 DB - PRIME DP - Unbound Medicine ER -